29003-60-9

Basic information

• Product Name: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)
• Synonyms: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)
• CAS NO: 29003-60-9
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.06462
• Product Categories: ACETYLHALIDE
• Mol File: 29003-60-9.mol
• Article Data: 23

Chemical Properties

• Melting Point: 77–78°C
• Appearance: /
• CAS DataBase Reference: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)(29003-60-9)
• EPA Substance Registry System: Ethanone, 2,2-dichloro-1-(4-methoxyphenyl)- (9CI)(29003-60-9)

Safety Data

• Hazardous Substances Data: 29003-60-9(Hazardous Substances Data)

Usage

Preparation

Preparation by treatment of anisole with benzyltrimethylammonium tetrachlor-oiodate (BTMA ICl4) in acetic acid at 70° for 5 h (78%)Also obtained by reaction of anisole with dichloroacetyl chloride in the presence of aluminium chloride.

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 100-66-3 methoxybenzene 
• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 100-09-4 4-methoxybenzoic acid 
• 94-30-4 ethyl 4-methoxybenzoate 
• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 36458-91-0 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one 
• 14337-31-6 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-ol 
• 123-11-5 4-methoxy-benzaldehyde 
• 64-19-7 acetic acid 
• 768-60-5 4-methoxyphenylacetylen 
• 86002-03-1 2-Benzenesulfinyl-2,2-dichloro-1-(4-methoxy-phenyl)-ethanol 

Downstream Products

• 3532-17-0 4-methoxybenzoyl azide 
• 126679-87-6 N-benzyl-N’-(4-methoxyphenyl)urea 
• 7465-87-4 N-benzyl-4-methoxybenzamide 
• 15982-64-6 1,4-bis(4-methoxyphenyl)butane-1,4-dione 
• 2132-70-9 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene 
• 79881-28-0 1,4-bis(4-methoxyphenyl)-2,3-dichloro-2-butene-1,4-dione 
• 36458-91-0 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one 
• 100-09-4 4-methoxybenzoic acid 
• 79881-24-6 1,4-bis(4-methoxyphenyl)-2,2,3,3-tetrachloro-1,4-butanedione 
• 58622-56-3 α-(dichloromethyl)-4-methoxybenzenemethanol 
• 7099-91-4 p-methoxybenzoylformic acid 

Relevant articles and documents

Dichloroacetophenone Derivatives: A Class of Bioconjugation Reagents for Disulfide Bridging

A mild and biocompatible method for the construction of disulfide bridging in peptides using dichloroacetophenone derivatives is developed. This method is highly selective (chemo, diastereo, regio, etc.) and atom economic and works under biocompatible reaction conditions (metal-free, water, pH 7, rt, etc.).

One-pot dichlorinative deamidation of primary β-ketoamides

An approach to the dichlorinative deamidation of primary β-ketoamides through ketonic cleavage is described, and a series of α,α-dichloroketones were furnished mostly in the presence of TEMPO. Based on control experiments, a mechanism involving tandem dichlorination and deamidation is proposed to interpret the observed reactivity.