36458-91-0

Basic information

• Product Name: 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one
• Synonyms: 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one
• CAS NO: 36458-91-0
• Molecular Weight: 253.512
• Mol File: 36458-91-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one(36458-91-0)
• EPA Substance Registry System: 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one(36458-91-0)

Safety Data

• Hazardous Substances Data: 36458-91-0(Hazardous Substances Data)

Upstream product

• 100-66-3 methoxybenzene 
• 545-06-2 trichloroacetonitrile 
• 14337-31-6 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-ol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 75-87-6 chloral 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 123-11-5 4-methoxy-benzaldehyde 
• 110374-86-2 2,2,2-Trichloro-1-(4-methoxy-phenyl)-ethane-1,1-diol 
• 29003-60-9 2,2-dichloro-4'-methoxyacetophenone 

Downstream Products

• 110374-86-2 2,2,2-Trichloro-1-(4-methoxy-phenyl)-ethane-1,1-diol 
• 29003-60-9 2,2-dichloro-4'-methoxyacetophenone 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 6873-44-5 p-chloro-N-methylbenzamide 
• 121-98-2 methyl 4-methoxybenzoate 
• 55685-70-6 Methoxy-(4-methoxy-phenyl)-methanol 
• 1273584-05-6 (S)-5,5,5-trichloro-4-hydroxy-4-(4-methoxyphenyl)pentan-2-one 
• 19670-94-1 C₁₆H₁₄⁽²⁾HCl₃O₂ 
• 100-09-4 4-methoxybenzoic acid 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

A study on reactions of an alkynylsilane with oxone-KX (X = Cl, Br, I) and its one-pot transformation into an amide/ester

Oxyhalogenation reactions of a variety of alkynylsilanes were studied using oxone as mild oxidant and KCl, KBr, and KI as halogen sources. In this study, reaction of an alkynylsilane with oxone-KX (X = Cl or Br) produced trichloromethyl/tribromomethyl ketones inhigh yields. Under similar conditions, however, reactions of alkynylsilanes with oxone-KI were found to give exclusively 1,2,2-triiodovinyl derivatives in high yields. In this study, new methods were deveoped for effcient one-pot tranformation of alkynylsilanes into amides and esters by reaction with amines and alcohols respectively via trihalomethyl ketone.

Transition-metal-free transformation of aryl bromides into aromatic esters and amides via aryl trichloromethyl ketones

A variety of aryl bromides have been treated with Mg and then chloral, followed by tBuOCl and subsequently alcohols or amines to produce the corresponding aromatic esters or amides in good yields via the formation of aryl trichloromethyl ketones as intermediates. These reactions are examples of a transition-metal-free one-pot preparation of aromatic esters and amides from aryl bromides. Aryl bromides have been treated with Mg and then chloral, followed by tBuOCl or tBuOCl with I2 as an additive, and subsequently alcohols or amines to form the corresponding aromatic esters and aromatic amides via aryl trichloromethyl ketones as intermediates. Copyright

Synthesis of 1-chloroalkynes from alkynylsilanes using trichloroisocyanuric acid as chlorinating agent

A new method is reported for preparing 1-chloroalkynes from alkynylsilanes using trichloroisocyanuric acid (TCCA) as chlorinating agent and AgNO 3 for in situ desilylation. The method is selective for trimethylsilyl-protected alkynes relative t