3007-53-2Relevant academic research and scientific papers
NMR Relaxation in Isotropic Surfactant Systems. A 2H, 13C, and 14N NMR Study of the Micellar (L1) and Cubic (I1) Phases in the Dodecyltrimethylammonium Chloride/Water System
Soderman, Olle,Walderhaug, Harald,Henriksson, Ulf,Stilbs, Peter
, p. 3693 - 3701 (1985)
A 2H, 13C, 14N NMR spin relaxation study of micellar solutions and cubic liquid-crystalline phases formed in the two-component system dodecyltrimethylammonium chloride (DOTAC)1/water is presented.In particular, based on multifield 2H NMR relaxation data, covering the frequency range 1.8-55.2 MHz, it is concluded that the NMR spin relaxation in ordinary micelles is determined by the fast local motion (trans-gauche isomerization) of the CD2 segment of the hydrocarbon chains of the monomers and the rotational tumbling of the micelles and diffusion of monomers over the (curved) micellar surface.There is no need to invoke other motions to explain the spin relaxation over a wide frequency range for he micellar case.For the cubic phase at high water content, the relaxation data are interpreted in favor of a novel structure, recently presented for this phase.The data also indicate that the interior or the amphiphilic aggregates is liquidlike and that the orientational order imposed by the hydrophobic-hydrophylic interface depends only weakly on the geometry of aggregates.
POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides
Bi, Xiaojing,Li, Junchen,Shi, Enxue,Li, Yu,Liu, Ying,Wang, Hongmei,Xiao, Junhua
supporting information, p. 236 - 240 (2019/04/25)
Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.
Ni-Catalyzed Α-Alkylation of Unactivated Amides and Esters with Alcohols by Hydrogen Auto-Transfer Strategy
Midya, Siba P.,Rana, Jagannath,Pitchaimani, Jayaraman,Nandakumar, Avanashiappan,Madhu, Vedichi,Balaraman, Ekambaram
, p. 3911 - 3916 (2018/11/23)
A transition-metal-catalyzed borrowing hydrogen/hydrogen auto-transfer strategy allows the utilization of feedstock alcohols as an alkylating partner, which avoids the formation of stoichiometric salt waste and enables a direct and benign approach for the construction of C-N and C?C bonds. In this study, a nickel-catalyzed α-alkylation of unactivated amides and ester (tert-butyl acetate) is carried out by using primary alcohols under mild conditions. This C?C bond-forming reaction is catalyzed by a new, molecularly defined nickel(II) NNN-pincer complex (0.1–1 mol %) and proceeds through hydrogen auto-transfer, thereby releasing water as the sole byproduct. In addition, N-alkylation of cyclic amides under Ni-catalytic conditions is demonstrated.
FeCl3 catalyzed amide compound synthesis method
-
Paragraph 0075; 0076; 0077; 0078; 0079, (2018/03/28)
The invention relates to an FeCl3 catalyzed amide compound synthesis method. According to the synthesis method, carboxylic acid and N-substituted formamide are employed to synthesize an amide compound under the catalysis of FeCl3. The synthesis method provided by the invention has the characteristics of mild conditions, high reaction efficiency, and wide applicability to substrates of different functional groups. The amide compound efficiently constructed by the invention is an important skeleton of many organic molecules, drugs, proteins and bioactive molecules. The synthesis method provided by the invention provides a widely applicable preparation method for synthesis of the compounds.
Pd(PPh3)4 catalyzed amide compound synthesis method
-
Paragraph 0086; 0087; 0088; 0089; 0090, (2017/12/27)
The invention relates to a Pd(PPh3)4 catalyzed amide compound synthesis method. The synthesis method takes carboxylic acid as the substrate, and adopts N-substituted formamide as the amine source to synthesize an amide compound under the catalysis of Pd(PPh3)4. The method is widely applicable to substrates with different functional groups. The amide compound efficiently constructed by the invention is an important skeleton of many organic molecules, drugs, peptides, bioactive molecules and natural products. The synthesis method provided by the invention provides a widely applicable preparation method for synthesis of the compounds.
Aliphatic carboxylic acid amide preparation method
-
Paragraph 0058; 0059; 0067; 0068, (2017/01/09)
The invention relates to a preparation method of aliphatic carboxylic acid amide. The method comprises the following step: carrying out a reaction on aliphatic carboxylic acid and monoalkylamine or dialkylamine with 1-4 carbon atoms in the presence of ceric oxide. By using the method, aliphatic carboxylic acid amide can be prepared with high yield, and a catalyst shows an excellent catalytic efficiency and reusing stability.
Method for synthesizing phosphorus-oxychloride-promoted amide compound
-
Paragraph 0110; 0111; 0112; 0113; 0114, (2017/01/26)
The invention relates to a method for synthesizing a phosphorus-oxychloride-promoted amide compound. The synthesizing method includes the steps that carboxylic acid serves as one reactant, another reactant (N,N-dialkyl methanamide) serves as a solvent, one equivalent of phosphorus oxychloride is added, and the amide compound is prepared. The reaction substrates are low in price and easy to get, the nature is stable, toxicity is small, the reaction speed is high, conditions are moderate, and the reaction substrates can be widely applied to substrates with different functional groups. The efficiently-constructed amide compound is an important molecular skeleton for many medicines, bioactive molecules and natural products, and the synthesizing method is a widely-applicable preparing method for synthesizing the compound.
Metal-Free Amidation of Acids with Formamides and T3P
Bannwart, Linda,Abele, Stefan,Tortoioli, Simone
, p. 2069 - 2078 (2016/07/06)
A new, simple and metal-free method for the direct formation of dialkylamides from carboxylic acids employing N,N-dialkylformamides as amine source is described. The one-pot reaction is promoted by propylphosphonic anhydride (T3P) in the presence of 0.5 equivalents of HCl.
Ru-catalyzed direct amidation of carboxylic acids with N-substituted formamides
Bi, Xiaojing,Li, Junchen,Shi, Enxue,Wang, Hongmei,Gao, Runli,Xiao, Junhua
, p. 8210 - 8214 (2016/11/23)
The direct amidation of carboxylic acids with N-substituted formamides has been accomplished via ruthenium catalysis. In the presence of ruthenium catalyst, a versatile range of carboxylic acids and N-substituted formamides undergoes amidation reaction to produce synthetically useful amides in good yields. C[dbnd]O in amide product came from benzoic acid but not N-substituted formamides, and which was confirmed by Isotope experiment.
Chemoselective intermolecular α-arylation of amides
Peng, Bo,Geerdink, Danny,Fares, Christophe,Maulide, Nuno
supporting information, p. 5462 - 5466 (2014/06/09)
A new approach for the fully chemoselective α-arylation of amides is presented. By means of electrophilic amide activation, aryl groups can be regioselectively introduced α- to amides, even in the presence of esters and alkyl ketones. Mechanistic studies reveal key reaction intermediates and emphasize a remarkably subtle base effect in this transformation. Arylating me softly: A new approach for the fully chemoselective α-arylation of amides has been developed. When electrophilic amide activation is employed, aryl groups can be regioselectively introduced in the position α to the amide, and that even in the presence of esters or alkyl ketones. Mechanistic studies emphasize a remarkably subtle base effect in this transformation.
