3049-45-4

Basic information

• Product Name: 3,5-DIPHENYL-4H-1,2,4-TRIAZOL-4-AMINE
• Synonyms: 3,5-DIPHENYL-4H-1,2,4-TRIAZOL-4-AMINE;4-Amino-3,5-diphenyl-4H-1,2,4-triazole;[3,5-di(phenyl)-1,2,4-triazol-4-yl]amine;3,5-di(phenyl)-1,2,4-triazol-4-amine
• CAS NO: 3049-45-4
• Molecular Formula: C₁₄H₁₂N₄
• Molecular Weight: 236.27
• Mol File: 3049-45-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 255-258°C
• Boiling Point: 471.4°Cat760mmHg
• Flash Point: 238.9°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 4.67E-09mmHg at 25°C
• Refractive Index: 1.677
• PKA: 2.29±0.10(Predicted)
• CAS DataBase Reference: 3,5-DIPHENYL-4H-1,2,4-TRIAZOL-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIPHENYL-4H-1,2,4-TRIAZOL-4-AMINE(3049-45-4)
• EPA Substance Registry System: 3,5-DIPHENYL-4H-1,2,4-TRIAZOL-4-AMINE(3049-45-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3049-45-4(Hazardous Substances Data)

Usage

General Description

3,5-DIPHENYL-4H-1,2,4-TRIAZOL-4-AMINE is a chemical compound with the molecular formula C15H13N5. It is a member of the triazole family, which are organic compounds containing a five-membered ring of two carbon atoms and three nitrogen atoms. 3,5-DIPHENYL-4H-1,2,4-TRIAZOL-4-AMINE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also known for its potential biological activities, such as anti-inflammatory and anti-cancer properties, making it a subject of interest in medicinal chemistry research. Additionally, 3,5-DIPHENYL-4H-1,2,4-TRIAZOL-4-AMINE has been studied for its potential application in material science, particularly in the development of organic electronic devices and materials.

InChI:InChI=1/C14H12N4/c15-18-13(11-7-3-1-4-8-11)16-17-14(18)12-9-5-2-6-10-12/h1-10H,15H2

Upstream product

• 93-89-0 benzoic acid ethyl ester 
• 14478-73-0 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine 
• 787-84-8 N'-benzoylbenzohydrazide 
• 825-60-5 benzimidic acid ethyl ester 
• 30082-57-6 benzylidene-(3,5-diphenyl-[1,2,4]triazol-4-yl)-amine 
• 100-47-0 benzonitrile 
• 75-05-8 acetonitrile 
• 65-85-0 benzoic acid 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 20375-31-9 ethyl benzoate benzoylhydrazone 
• 613-94-5 benzoic acid hydrazide 
• 7803-57-8 hydrazine hydrate 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 

Downstream Products

• 3026-70-8 N-(3,5-diphenyl-[1,2,4]triazol-4-yl)-diacetamide 
• 30082-57-6 benzylidene-(3,5-diphenyl-[1,2,4]triazol-4-yl)-amine 
• 54413-55-7 4-amino-1-methyl-3,5-diphenyl-[1,2,4]triazolium; iodide 
• 2039-06-7 3,5-diphenyl-1,2,4-triazole 
• 1427471-21-3 2-{[3-(3,5-diphenyl-1H-1,2,4-triazol-1-yl)propyl]sulfanyl}-1,3-benzothiazole 
• 30082-71-4 (3,5-diphenyl-[1,2,4]triazol-4-yl)-(2-nitro-benzylidene)-amine 
• 30082-73-6 (N-(4-nitrobenzylidene)-4H-3,5-diphenyl-1,2,4-triazole-4-amine) 
• 1408218-73-4 N,N'-(2,2'-(2,2'-(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(oxy)bis(2,1-phenylene))bis(methan-1-yl-1-ylidene)bis(3,5-diphenyl-4H-1,2,4-triazol-4-amine) 
• 1408218-68-7 N,N'-(2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(2,1-phenylene))bis(methan-1-yl-1-ylidene)bis(3,5-diphenyl-4H-1,2,4-triazol-4-amine) 
• 1408218-65-4 N,N'-(2,2'-(2,2'-(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(oxy)bis(3-methoxy-2,1-phenylene))bis(methan-1-yl-1-ylidene)bis(3,5-diphenyl-4H-1,2,4-triazol-4-amine) 
• 1408218-76-7 N,N'-(2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(3-methoxy-2,1-phenylene))bis(methylene)bis(3,5-diphenyl-4H-1,2,4-triazol-4-amine) 

Relevant articles and documents

Selective Zn2+ recognition of novel triazole Schiff-base derivatives bearing the coumarin group

Three novel triazole Schiff-bases derivatives bearing coumarin units have been synthesised from 3,5-diaryl-4-amino-1,2,4-triazole with three kinds of coumarin aldehydes. The UV.Vis absorption and fluorescence emission spectra of (E )-4-((3,5-diphenyl-4H-

Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H

In the past decade, the work on the identification of small molecular weight compounds as inhibitors of cysteine proteases has been in focus. In this direction, we here present the facile microwave assisted synthesis of some acyl hydrazides and triazoles, followed by their evaluation as protease inhibitors and inhibitory studies on cathepsin B and cathepsin H, two significant lysosomal cysteine proteases. The compounds were characterized by 1H NMR, 13C NMR, Mass and IR spectral data. The compounds which were found inhibitory to endogenous proteolysis in liver homogenate at pH 5.0 were further studied for determination of inhibition type and Ki values on purified cathepsin B and cathepsin H. The maximum inhibitory effect was exerted by 3-(3′-nitrophenyl)-5-(3′-nitrophenyl)-4-amino-1,2,4-triazoles (2c), 3-(4′-chlorophenyl)-5-(4′-chloro phenyl)-4-amino-1,2,4- triazoles (2h), 3-(3′-aminophenyl)-5-(3′-aminophenyl)-4-amino-1,2,4- triazoles (2i) and 4-methoxybenzohydrazide (1b).

Synthesis and biological evaluation of some novel 3,5-disubstituted-1,2,4- triazole incorporated 2-mercaptobenzothiazoles

Several 2-mercaptobenzothiazole derivatives 5a-i containing 1,2,4-triazole moiety incorporating two additional substituents were synthesized. All the newly synthesized compounds were tested for in vitro activity against certain strains of bacteria such as Enterococcus faecalis, Bacillus coagulans, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. Compound 5a showed significant activity against the Gram-negative bacteria Escherichia coli. Compounds 5a-i were also screened for their antifungal activity against Candida albicans and compounds 5a, 5b, 5d and 5g displayed significant activity against this fungus. Some of these compounds were evaluated for their in vivo anti-inflammatory activity, acute toxicity and ulcerogenic actions. Tested compounds 5g and 5h showed significant anti-inflammatory activity and significant gastrointestinal protection compared to the standard drug diclofenac sodium. Molecular modeling studies of the synthesized compounds are presented.