30507-16-5

Basic information

• Product Name: 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one
• Synonyms: 3-(4-Methoxy-phenyl)-2-methyl-3H-quinazolin-4-one; 4(3H)-quinazolinone, 3-(4-methoxyphenyl)-2-methyl-
• CAS NO: 30507-16-5
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.2946
• Mol File: 30507-16-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 448.5°C at 760 mmHg
• Flash Point: 225°C
• Density: 1.19g/cm³
• Vapor Pressure: 3.1E-08mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one(30507-16-5)
• EPA Substance Registry System: 3-(4-methoxyphenyl)-2-methylquinazolin-4(3H)-one(30507-16-5)

Safety Data

• Hazardous Substances Data: 30507-16-5(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 89-52-1 o-acetylamino-benzoic acid 
• 36684-49-8 2-iodo-N-(4-methoxyphenyl)benzamide 
• 143-37-3 acetamidine 
• 100-17-4 para-methoxynitrobenzene 
• 615-43-0 2-iodophenylamine 
• 108-24-7 acetic anhydride 
• 118-92-3 anthranilic acid 
• 20878-54-0 2-amino-N-(4-methoxyphenyl)benzamide 
• 22378-45-6 3-(4-Methoxy-phenyl)-3H-quinazolin-4-one 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 134-20-3 2-carbomethoxyaniline 
• 75-05-8 acetonitrile 
• 95970-05-1 2,6-dibromo-4-methoxyaniline 

Downstream Products

• 30507-26-7 (E)-3-(4-methoxyphenyl)-2-(4-methoxystyryl)quinazolin-4(3H)-one 
• 115781-70-9 3-(p-methoxyphenyl)-2-styryl-3,4-dihydro-4-quinazolone 
• 80884-20-4 2-[(2,4-Dichloro-benzylamino)-methyl]-3-(4-methoxy-phenyl)-3H-quinazolin-4-one 
• 80884-17-9 2-{[2-(4-Chloro-phenyl)-ethylamino]-methyl}-3-(4-methoxy-phenyl)-3H-quinazolin-4-one 
• 80884-15-7 3-(4-Methoxy-phenyl)-2-[(2-p-tolyl-ethylamino)-methyl]-3H-quinazolin-4-one 
• 80884-25-9 2-Bromomethyl-3-(4-methoxy-phenyl)-3H-quinazolin-4-one 
• 1789-09-9 1-(2-methyl-4-oxo-4H-quinazolin-3-yl)-4-hydroxybenzene 

Relevant articles and documents

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

Preparation of 4(3H)-quinazolinones from aryldiazonium salt, nitriles and 2-aminobenzoate via a cascade annulation

One-pot synthesis of 3-aryl-4(3H)-quinazolinones has been realized through a cascade annulation. Reaction of aryldiazonium salt with a nitrile provides in situ generation of a reactive nitrilium ion, which is attacked by the amino group of 2-aminobenzoate followed by cyclization to deliver the desired product. This strategy offers a convenient and easy access to a wide range of functionalized quinazolinone.

Catalytic Enantioselective Synthesis of N-C Axially Chiral Mebroqualone and Its Derivatives through Reductive Asymmetric Desymmetrization

In the presence of (R)-DTBM-SEGPHOS-Pd(OAc)2 catalyst, treatment of various 3-(2,6-dibromophenyl)quinazolin-4-ones with NaBH4 gave optically active N-C axially chiral quinazolinone (mebroqualone) derivatives through reductive asymmet