3067-19-4

Basic information

• Product Name: N-Acetyl-DL-valine
• Synonyms: AC-DL-VAL-OH;ACETYL-DL-VALINE;ACETYL-DL-VALINE, N-;N-ACETYL-L(DL)-VALINE;N-ACETYL VALINE;N-ACETYL-DL-VALINE;N-A-ACETYL-DL-VALINE;Valine, N-acetyl-
• CAS NO: 3067-19-4
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18
• EINECS: 221-321-4
• Product Categories: Amino Acids;Amino Acid Derivatives;Ac-Amino Acids;Amino Acids (N-Protected);Biochemistry;Amino Acid Derivatives;Peptide Synthesis;Valine;amino acid;amino
• Mol File: 3067-19-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 148°C
• Boiling Point: 362.2 °C at 760 mmHg
• Flash Point: 172.8 °C
• Appearance: COA
• Density: 1.094 g/cm³
• Vapor Pressure: 3.14E-06mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: Store at 0
• Solubility: 37g/l (experimental)
• PKA: 3.62±0.10(Predicted)
• BRN: 1723835
• CAS DataBase Reference: N-Acetyl-DL-valine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-DL-valine(3067-19-4)
• EPA Substance Registry System: N-Acetyl-DL-valine(3067-19-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: WGK 3 highly water endangering
• Hazardous Substances Data: 3067-19-4(Hazardous Substances Data)

Usage

Uses

N-Acetyl-DL-Valine is an amino acid.

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 2829, 1987 DOI: 10.1016/S0040-4039(00)96220-8

InChI:InChI=1/C7H13NO3/c1-4(2)6(7(10)11)8-5(3)9/h4,6H,1-3H3,(H,8,9)(H,10,11)/t6-/m0/s1

Upstream product

• 6642-21-3 2-acetylamino-3-methyl-crotonic acid 
• 516-06-3 D,L-valine 
• 830-03-5 4-nitrophenol acetate 
• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 72-18-4 L-valine 
• 64-19-7 acetic acid 
• 759-05-7 3-methyl-2-ketobutanoic acid 
• 78-84-2 isobutyraldehyde 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 64724-68-1 diethyl 2-N-acetylamino-2-isopropylmalonate 

Downstream Products

• 109924-94-9 Ac-(R,S)-Val-(R,S)-PhSer-OMe 
• 114285-08-4 C₇H₁₂NO₃ 
• 72-18-4 L-valine 
• 17916-88-0 N-acetyl-D-valine 
• 251988-77-9 N-[2-methyl-1-(4-methyl-benzoyl)-propyl]-acetamide 
• 17623-72-2 2-methyl-4-iso-propyl-4H-oxazolin-5-one 
• 1394018-10-0 N-(3-methyl-1-(4-nitrophenyl)-1-oxobutan-2-yl)acetamide 
• 110409-07-9 Ac-(R,S)-Val-(R,S)-PhSer-OH 
• 109924-99-4 racemic Ac-Val-ΔPhe-OMe 
• 109924-97-2 racemic Ac-Val-ΔPhe-azlactone 
• 96574-45-7 N²-<(S)-N²-acetylvalyl>-L-phenylalanine dimethylamide 
• 96574-46-8 N²-<(R)-N²-acetylvalyl>-L-phenylalanine dimethylamide 
• 96-81-1 N-acetyl-L-valine 
• 923954-52-3 N-acetyl-ambo-valyl-ambo-alanine methyl ester 

Relevant articles and documents

Reactivity of α-Amino Acids in the Reaction with Esters in Aqueous–1,4-Dioxane Media

The kinetics of the reaction of a series of α-amino acids with 4-nitrophenyl acetate, 4-nitrophenyl benzoate, and 2,4,6-trinitrophenyl benzoate in aqueous 1,4-dioxane medium has been studied. Kinetics of the reactions involving 4-nitrophenyl acetate and 2,4,6-trinitrophenyl benzoate has complied with the Br?nsted dependence and revealed linear correlation between rate constant logarithm and the energy difference of the frontier orbitals of α-amino acids anions.

Amidoearbonylation of aldehydes utilizing cobalt oxide-supported gold nanoparticles as a heterogeneous catalyst

Cobalt oxide-supported gold-nanoparticles-catalyzed transformation of aldehydes and their equivalents to N-acyl-α-arnino acids was achieved. The desired products were obtained in moderate to excellent yields under milder reaction conditions than previous reports employing octacarbonyldicobalt as a catalyst. Copyright

Palladium-catalyzed amidocarbonylation improved by recyclable ionic liquids

Two types of ionic liquids (halide anion ionic liquids and Brensted acidic ionic liquids) were first applied to improve the palladium-catalyzed amidocarbonylation. Both the palladium catalyst and the ionic liquids could be recycled at least five times without significant loss in catalytic activity. Georg Thieme Verlag Stuttgart.