30693-34-6Relevant academic research and scientific papers
Amine-functionalized nano-NaY zeolite for the synthesis of N-acetyl pyrazoles and dihydropyrimidines
Razavian Mofrad, Raheleh,Kabirifard, Hassan,Tajbakhsh, Mahmood,Firouzzadeh Pasha, Ghasem
, (2021/08/23)
An efficient base-catalyzed synthesis of dihydropyrimidines and N-acetyl pyrazoles is reported using 1-(2-aminoethyl)piperazine-modified nano-NaY zeolite (ZeSi–AP) under mild and green conditions. The structure of the catalyst was identified by using FT-IR, XRD, TGA, DTA, DLS, SEM, TEM, and elemental analyses. This heterogeneous catalyst has many benefits, such as a simple work-up procedure, high product yield, and it is easily regenerated and reused at least for four cycles without losing its activity.
Synthesis of some new n-acetylated pyrazoline derivatives via the efficient one-pot reaction by using p-toluenesulfonic acid
Khodadad, Hadis,Pourshamsian, Khalil,Hatamjafari, Farhad,Sadeghi, Babak
, p. 165 - 171 (2021/02/05)
A series of a new class of N-acetylated pyrazoline derivatives were synthesized by treatment of chalcones with hydrazine hydrate and acetic anhydride or oxalic acid in the presence of the catalytic amount of p-toluenesulfonic acid in ethanol. All synthesized products were characterized by FT-IR, 1H, and 13C NMR spectral data and elemental analyses. Some advantages of this protocol are a simple work-up procedure, time-consuming reaction and good to high yields.
Synthesis of some new n-acetylated pyrazoline derivatives via the efficient one-pot reaction by using p-toluenesulfonic acid
Hatamjafari, Farhad,Khodadad, Hadis,Pourshamsian, Khalil,Sadeghi, Babak
, p. 165 - 171 (2020/10/06)
A series of a new class of N-acetylated pyrazoline derivatives were synthesized by treatment of chalcones with hydrazine hydrate and acetic anhydride or oxalic acid in the presence of the catalytic amount of p-toluenesulfonic acid in ethanol. All synthesized products were characterized by FT-IR, 1H, and 13C NMR spectral data and elemental analyses. Some advantages of this protocol are a simple work-up procedure, timeconsuming reaction and good to high yields.
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H
Raghav, Neera,Singh, Mamta
supporting information, p. 4233 - 4245 (2014/08/18)
Cathepsins have emerged as potential drug targets for melanoma therapy and engrossed attention of researchers for development and evaluation of cysteine cathepsin inhibitors as cancer therapeutics. In this direction, we have designed, synthesized, and ass
Solvent-free synthesis of some1-acetyl pyrazoles
Thirunarayanan, Ganesamoorthy,Sekar, Krishnamoorthy Guna
, p. 599 - 605 (2013/11/06)
Some N-acetyl pyrazoles including 1-(3-(3,4-dichlorophenyl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-yl) ethanones have been synthesised by solvent free cyclization cum acetylation of chalcones like substituted styryl 3,4-dichlorophenyl
Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones
Nepali, Kunal,Kadian, Kanika,Ojha, Ritu,Dhiman, Rajni,Garg, Atul,Singh, Gagandip,Buddhiraja, Abhishek,Bedi, Preet Mohinder Singh,Dhar, Kanaya Lal
, p. 2990 - 2997 (2012/10/29)
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C6-C 3-C6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines. Springer Science+Business Media, LLC 2011.
Anticonvulsant activity of a combined pharmacophore of pyrazolo-pyridines with lesser toxicity in mice
Siddiqui, Nadeem,Ahsan, Waquar,Alam, M. Shamsher,Ali, Ruhi,Srivastava, Kamna,Ahmed, Sharique
, p. 576 - 582 (2011/12/03)
Various 2-amino-6-[3-(substituted phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl] -4-(substituted phenyl)nicotinonitriles (3a-t) were designed and synthesized by clubbing two active anticonvulsant pharmacophores pyrazole and pyridine. All the synthesized compounds possessed the pharmacophoric elements essential for good anticonvulsant activity. The anticonvulsant screening was performed by maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) tests. Two compounds 3i and 3s showed significant anticonvulsant activity in both the screens with ED50 values 17.5 mg/kg and 22.6 mg/kg respectively in MES screen and 154.1 mg/kg and 242.6 mg/kg respectively in scPTZ screen. They were also found to have no acute toxic effects in mice when tested at elevated doses.
Enantioselective phase-transfer catalysis: Synthesis of pyrazolines
Make, Olivier,Dez, Isabelle,Levacher, Vincent,Briere, Jean-Francois
supporting information; experimental part, p. 7072 - 7075 (2010/11/05)
All paired up: Under catalytic phase-transfer conditions the formation of a chiral ion pair between quininium cation 1 and hydrazine anion 2 led to an enantioselective aza-Michael cyclocondensation domino reaction to furnish pyrazolines. A convenient one-pot protocol allowed exchange of the functional group (R1) on the nitrogen atom.
TBD-organocatalysed synthesis of pyrazolines
Mahe, Olivier,Frath, Denis,Dez, Isabelle,Marsais, Francis,Levacher, Vincent,Briere, Jean-Franois
supporting information; experimental part, p. 3648 - 3651 (2009/10/23)
It was found that TBD, a cheap and commercially available guanidine, easily catalysed the synthesis of biologically important 3,5-diarylpyrazolines from chalcones and acylhydrazines via a selective secondary amine alkylation.
A divergent approach to the synthesis of 3-substituted-2-pyrazolines: Suzuki cross-coupling of 3-sulfonyloxy-2-pyrazolines
Grimm, Jonathan B.,Wilson, Kevin J.,Witter, David J.
supporting information; experimental part, p. 6390 - 6393 (2009/12/06)
(Chemical Equation Presented) The efficient Suzuki cross-coupling of pyrazoline nonaflates with organoboron reagents was achieved to afford diverse 3-substituted-2-pyrazolines in excellent yield. The nonaflates displayed improved reactivity over the corre
