312-24-3

Upstream product

• 360-03-2 2,2-Difluoro-2-phenylacetic acid 
• 40626-45-7 α,α-dichlorobenzylcyanide 
• 2002-72-4 α,α-difluorobenzeneacetonitrile 
• 383-19-7 2,2-difluoro-2-phenylacetamide 

Downstream Products

• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 1574401-91-4 ethyl 6-(difluoro(phenyl)methyl)nicotinate 
• 1041934-93-3 C₁₀H₁₁F₂NO₂ 
• 19450-54-5 2,2-Difluoro-N-(octahydro-naphthalen-4a-yl)-2-phenyl-acetamide 
• 339-30-0 2,2-difluoro-N-2-diphenylacetamide 

Relevant academic research and scientific papers

Synthesis of N-trifluoromethyl amides from carboxylic acids

Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.

(Het)aryl Difluoromethyl-Substituted β-Alkoxyenones: Synthesis and Heterocyclizations

An efficient approach to the preparation of β-alkoxyenones bearing (het)aryl difluoromethyl substituents is described. The method included acylation of acyclic or cyclic vinyl ethers with (het)aryl difluoroacetyl chlorides. The method worked well for most

A scalable and regioselective synthesis of 2-difluoromethyl pyridines from commodity chemicals

A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows access to a diverse range of substitution patterns on all positions on the ring system and on the difluoromethyl group.

N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS

Compounds represented by Formula (I): and/or pharmaceutically acceptable salts, individual enantiomers and stereoisomers thereof, are effective as NMDA/NR2B antagonists useful for treating conditions such as pain, Parkinson’s disease, Alzheimer’s disease, epilepsy, depression, anxiety, ischemic brain injury including stroke.