3141-59-1Relevant academic research and scientific papers
1,4-Conjugate additions of methoxyamine and 1,1-dimethylhydrazine to hex-3-yne-2-one: A facile synthesis of functionalized isoxazole and pyrazole precursors
Sauers, Ronald R.,Van Arnum, Susan D.
, p. 2033 - 2038 (2007/10/03)
When hex-3-yne-2,5-dione (2) was reacted with either methoxyamine or 1,1-dimethylhydrazine, the 1,4-addition products 4 and 7 were isolated in yields of 89% and 48% respectively. Copyright Taylor & Francis, Inc.
SOME NOVEL ISOXAZOLE PHOTOCHEMISTRY: A COMPARISON WITH VINYL AZIDE CHEMISTRY
Sauers, Ronald R.,Van Arnum, Susan D.
, p. 5797 - 5800 (2007/10/02)
Product profiles from the irradiations of 3-acetyl-5-methylisoxazole (4) and Z-3-azido-3-hexene-2,5-dione (5) were compared.Whereas both compounds gave rise to azirine 7, diacetylacetonitrile (6) was produced only from (4).
Ring Cleavage Reactions of 3- and 5-Non-substituted Isoxazoles
Alberola, A.,Gonzalez, A. M.,Guerra, D.,Pulido, F. J.
, p. 1073 - 1076 (2007/10/02)
5-Methylisoxazoles with electron-accepting groups at C-4 (Ia-c) and 2,3-dimethylisoxazolium iodide (II) undergo ring cleavage when treated with organic bases.The nature of the open chain products which were obtained (stable enolates, β-diketones, esters) depends on the group at C-4 and the strength of the base.In some of these processes aromatic aldehydes were used in order to determine the competition between the condensation and the cleavage reaction.The mechanism of the nucleophilic ring cleavage of II is also shown.
