31600-56-3

Usage

Uses

Used in the Paint and Coatings Industry:
[(2-methoxyethoxy)methyl]benzene is used as a solvent for enhancing the properties of paints, coatings, and adhesives. Its ability to dissolve a wide range of substances contributes to the improved performance and durability of these products.
Used in the Adhesives Industry:
In the adhesives industry, [(2-methoxyethoxy)methyl]benzene serves as a solvent that aids in the formulation of adhesives with specific bonding properties. Its use results in adhesives with better adhesion and resistance to various environmental conditions.
Used in the Synthesis of Specialty Chemicals:
[(2-methoxyethoxy)methyl]benzene is utilized as an intermediate in the synthesis of specialty chemicals. Its unique chemical structure allows for the creation of a variety of complex molecules with specific applications in different industries.
Used in the Pharmaceutical Industry:
Within the pharmaceutical sector, [(2-methoxyethoxy)methyl]benzene is employed in the synthesis of various drugs. Its role as a building block in the development of new medications highlights its importance in the healthcare field.
Safety and Environmental Considerations:
[(2-methoxyethoxy)methyl]benzene is considered to have low toxicity and is not expected to pose significant risks to human health or the environment when properly handled and used according to safety guidelines. However, it is crucial to handle this chemical with care and use appropriate personal protective equipment when working with it to minimize any potential hazards.

InChI:InChI=1/C10H14O2/c1-11-7-8-12-9-10-5-3-2-4-6-10/h2-6H,7-9H2,1H3

Upstream product

• 109-86-4 2-methoxy-ethanol 
• 100-39-0 benzyl bromide 
• 622-08-2 2-Benzyloxyethanol 
• 74-88-4 methyl iodide 
• 71412-83-4 benzaldehyde di-2-methoxyethyl acetal 
• 110-71-4 1,2-dimethoxyethane 
• 100-51-6 benzyl alcohol 
• 1327238-85-6 ((2-methoxyethoxy)methoxy)cyclohexane 
• 100-52-7 benzaldehyde 
• 3970-21-6 2-Methoxyethoxymethyl chloride 
• 591-51-5 phenyllithium 

Downstream Products

• 109-86-4 2-methoxy-ethanol 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Iridium solutes effect C-H bond activation and C-C bond forming reactions of C6H6-MeOCH2CH2OMe solvent mixtures

The in situ generated [TpMe2Ir(C6H5) 2] fragment induces both aromatic and aliphatic C-H bond activation reactions, along with C-C bond formation, when heated with benzene and 1,2-dimethoxyethane.

Vanadium-Catalyzed Oxidative Debenzylation of O-Benzyl Ethers at ppm Level

An advantageous methodology for the oxidative debenzylation of ethers has been developed. Very low amounts of a catalyst system based on vanadyl acetylacetonate and a triazole type pincer ligand allow the selective oxidative cleavage of a number of O-benzyl ethers in the presence of oxygen as the sole oxidant. The methodology tolerates a number of functional groups such as halo-, alkoxy-, or trifluoromethylarenes, alkyne, alkene, ether, and acetal units. Large-scale deprotections can be also carried out by the optimized procedure, which is amenable to enantioenriched reactants as well. (Figure presented.).

Asymmetric epoxidation of unfunctionalized olefins catalyzed by Jacobsen's catalyst on alkoxyl-modified zirconium poly (styrene-phenylvinylphosphonate)-phosphate (ZPS-PVPA)

New chiral Jacobsen's catalysts grafted onto alkoxyl-modified ZPS-PVPA are synthesized and applied in asymmetric epoxidations of unfunctionalized olefins. Specially, the supported catalysts indicate excellent catalytic activities (conv%, up to 96; sele%, up to 96; ee%, up to >99) in the absence of N-methylmorpholine N-oxide (NMO) by virtue of the special configurations of the catalysts. The superior stability (recycling for ten times) and the comfortable dispositions in large-scale reactions (such as 200 times) grant the potential application in industry to the heterogeneous catalysts.

Gold(I)-catalyzed synthesis of unsymmetrical ethers using alcohols as alkylating reagents

A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis.

COMPOSITIONS, SYNTHESIS, AND METHODS OF USING PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES

The present invention provides novel phenylcycloalkylmethylamme derivatives, and methods of preparing phenylcycloalkylmethylamme derivatives. The present invention also provides methods of using phenylcycloalkylmethylamme derivatives and compositions of phenylcycloalkylmethylamme derivatives. The pharmaceutical compositions of the compounds of the present invention can be used for treating and/or preventing obesity and obesity related co- morbid indications and depression and depression related co-morbid indications.

Expanded substrate scope and improved reactivity of ether-forming cross-coupling reactions of organotrifluoroborates and acetals

Mixed acetals and organotrifluoroborates undergo BF3· OEt2-promoted cross-couplings to give dialkyl ethers under simple, mild conditions. A survey of reaction partners identified a hydroxamate leaving group that improves the regioselectivity and product yield in the BF 3·OEt2-promoted coupling reaction of mixed acetals and potassium alkynyl-, alkenyl-, aryl- and heteroaryltrifluoroborates to access substituted dialkyl ethers. This leaving group enables the reaction to proceed rapidly under mild conditions (0 °C, 5-60 min) and permits reactions with electron-deficient potassium aryltrifluoroborates that are less reactive with other acetal substrates. A study of the reaction mechanism and characterization of key intermediates by NMR spectroscopy and X-ray crystallography identified a role for the hydroxamate moiety as a reversible leaving group that serves to stabilize the key oxocarbenium intermediate and the need for a slight excess of organodifluoroborane to serve as a catalyst. A secondary role for the boron nucleophile as an activating ligand was also considered. These studies provide the basis for a general class of reagents that lead to dialkyl ethers by a simple, predictable cross-coupling reaction.

Highly chemoselective lithium metal reductions of benzaldehyde bis(2-methoxyethyl) acetals

Naphthalene-catalysed reductions of PhCH(OR)2 (R = Me, CH2CH2OMe) acetals by lithium metal, followed by reactions with electrophiles (H+, TMSCl, nBuBr, CH2=CHCH2Br), proceed with high chemoselectivity when the reductions are carried out at -90 °C especially for R = CH2CH2OMe. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany 2002.

Catalytic C-C bond formation using triorganothallium reagents

The first catalytic system employing triorganothallium compounds in the formation of carbon-carbon bonds, is described.

A Study of the Rapid Anomerization of Poly-O-benzyl-β-D-glucopyranosides with Titanium Tetrachloride

Titanium tetrachloride rapidly anomerizes methyl 2,3,4,6-tetra-O-benzyl-β-D-glucopyranoside in dichloromethane at 25 deg C.Evidence for the proposal that the benzyloxymethyl group on C-5 and the ring oxygen of the glucoside cooperate to prompt the reaction is described.The reagent anomerizes the interglycosidic linkage of several disaccharide derivatives.

Veretherungen von Diolen, Triolen und Hydroxycarbonsaeurederivaten ueber Thallium(I)-alkoholate. Eine neue Variante der Williamson-Reaktion

The etherifications listed in tables 1 and 2 are achieved by converting hydroxy-derivatives, which contain additional oxygen functions, into thallium(I) alkoxides with thallium ethoxide, and treatment with haloalkanes.The scope and limitations of the method are discussed.