3164-28-1

Upstream product

• 833-50-1 2-phenylbenzo[d]oxazole 
• 3488-57-1 N-phenylbenzamidoxime 
• 65-85-0 benzoic acid 
• 121-88-0 5-Nitro-2-aminophenol 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 100-47-0 benzonitrile 
• 17200-30-5 6-nitrobenzo[d]oxazole 
• 100-52-7 benzaldehyde 
• 1663-61-2 triethoxymethylbenzene 
• 98-88-4 benzoyl chloride 
• 38880-89-6 N-(2-hydroxy-4-nitrophenyl)benzamide 
• 95-55-6 2-amino-phenol 
• 1624-53-9 2-(benzylideneamino)phenol 
• 5932-03-6 2-benzylideneamino-5-nitro-phenol 

Downstream Products

• 53421-88-8 2-phenyl-1,3-benzoxazol-6-ylamine 
• 65-85-0 benzoic acid 
• 1198404-55-5 6-(3-(4-chlorophenyl)-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazole 
• 1198404-56-6 6-(3-(3-methoxyphenyl)-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazole 
• 1198404-57-7 6-(3-(4-methoxyphenyl)-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazole 
• 1198404-58-8 2-phenyl-6-(3-p-tolyl-4H-1,2,4-triazol-4-yl)benzo[d]oxazole 
• 1134317-23-9 2-phenyl-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazole 
• 1198404-40-8 6-(3-methyl-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazole 
• 1198404-41-9 6-(3-ethyl-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazole 
• 1198404-43-1 2-phenyl-6-(3-propyl-4H-1,2,4-triazol-4-yl)benzo[d]oxazole 
• 1198404-45-3 6-(3-butyl-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazole 
• 1198404-46-4 6-(3-pentyl-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazole 

Relevant academic research and scientific papers

The unsuspected influence of the pyridyl-triazole ligand isomerism upon the electronic properties of tricarbonyl rhenium complexes: An experimental and theoretical insight

Two isomeric tricarbonyl rhenium(i) complexes, ReL1 and ReL2, that possess a 2-pyridyl-1,2,n-triazole (pyta) ligand (n = 4 and 3, respectively) connected to a 2-phenylbenzoxazole (PBO) moiety, were synthesized in good yields. The X-ray structures showed t

Oxidative cyclization and synthesis of benzoxazole derivatives and hydrolytic phosphatase activity studies on dinuclear diphenoxo-bridged zinc(II)complexes

Diphenoxo bridged dinuclear zinc complexes, [Zn2(Phimp)2(Cl)2] (1) (PhimpH = (E)-2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)phenol), [Zn2(Me-Phimp)2(Cl)2] (2) (Me-PhimpH = (E)-4-methyl-2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)phenol), [Zn2(OMe-Phimp)2(Cl)2] (3) (OMe-PhimpH = (E)-4-methoxy-2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)phenol), were synthesized and spectroscopically characterized. The molecular structure of 2 was determined using X-ray crystallography. DFT and TD-DFT calculations were performed to optimize the molecular geometry, interpret the spectroscopic results and investigate the contribution of the ligands to the redox properties of the complexes. Phenoxyl radical complexes were generated in solution via chemical oxidation using ceric ammonium nitrate (CAN) and the redox properties were examined through cyclic voltammetric measurements. The hydrolysis of para-nitrophenylphosphate (PNPP) by all the dinuclear zinc complexes was investigated to mimic phosphatase activity. Catalytic oxidative cyclization by these complexes and synthesis of benzoxazole derivatives was investigated.

Electrochemical Generation of Hypervalent Bromine(III) Compounds

In sharp contrast to hypervalent iodine(III) compounds, the isoelectronic bromine(III) counterparts have been little studied to date. This knowledge gap is mainly attributed to the difficult-to-control reactivity of λ3-bromanes as well as to their challenging preparation from the highly toxic and corrosive BrF3 precursor. In this context, we present a straightforward and scalable approach to chelation-stabilized λ3-bromanes by anodic oxidation of parent aryl bromides possessing two coordinating hexafluoro-2-hydroxypropanyl substituents. A series of para-substituted λ3-bromanes with remarkably high redox potentials spanning a range from 1.86 V to 2.60 V vs. Ag/AgNO3 was synthesized by the electrochemical method. We demonstrate that the intrinsic reactivity of the bench-stable bromine(III) species can be unlocked by addition of a Lewis or a Br?nsted acid. The synthetic utility of the λ3-bromane activation is exemplified by oxidative C?C, C?N, and C?O bond forming reactions.

Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease

In this study, four series of compounds with benzoxazolone and benzothiazolone cores were designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease (AD). Additionally, in order to shed light on the effect of the carbonyl groups of benzoxazolone/benzothiazolone, benzoxazole/benzothiazole-containing analogues were also synthesized and evaluated. Inhibition potency of all final compounds towards cholinesterase enzymes and their antioxidant activity were tested. Subsequently, the anti-inflammatory activity, cytotoxicity, apoptosis, and Aβ aggregation inhibition tests were also performed for selected compounds. The results indicated that compounds 11c, a pentanamide derivative with benzothiazolone core, and 14b, a keton derivative with benzothiazolone core, were considered as promising multi-functional agents for further investigation against AD. The reversibility, kinetic and molecular docking studies were also performed for the compounds with the highest AChE 14b (eeAChE IC50 = 0.34 μM, huAChE IC50 = 0.46 μM) and BChE 11c (eqBChE IC50 = 2.98 μM, huBChE IC50 = 2.56 μM) inhibitory activities.

Method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions

The invention discloses a method used for rapid preparation of benzo-heterocycle compound with physical grinding under solvent-free room temperature conditions. According to the method, glacial aceticacid is taken as a catalyst; at solvent-free room temperature conditions, physical grinding is adopted, reaction of 2-substituted arylamines (2-mercapto arylamine, 2-aminophenol, and o-phenylenediamine) and aromatic aldehydes is carried out using physical grinding. The method is friendly to the environment, is simple in operation, is safe, is low in cost, and is high in efficiency. Compared withthe prior art, the advantages are that: the method is suitable for a large amount of functional groups, yield is high, less by-product is generated, operation is simple, the method is safe, cost is low, and the method is friendly to the environment.

Zr and Hf-metal-organic frameworks: Efficient and recyclable heterogeneous catalysts for the synthesis of 2-arylbenzoxazole via ring open pathway acylation reaction

Zirconium- and hafnium-based metal–organic frameworks which constructed by 12-coordinated clusters and 6-coodinated clusters were shown to be highly effective heterogeneous catalysts for the ring opening acylation of benzoxazole to 2-arylbenzoxazole under solvent free conditions. Owning the wide opening spaces structures and inherent formate sites, MOFs based on 6-connected Zr6/Hf6 node were able to identify a significantly enhanced yield in Br?nsted acid catalyzed reactions under conventional heating and microwave irradiation. In addition, the detailed mechanism of active sites of the ring opening acylation reaction was confirmed by employing of density functional theory (DFT) calculations.

Synthesis of Benzoxazoles Using Electrochemically Generated Hypervalent Iodine

The indirect ("ex-cell") electrochemical synthesis of benzoxazoles from imines using a redox mediator based on the iodine(I)/iodine(III) redox couple is reported. Tethering the redox-active iodophenyl subunit to a tetra-alkylammonium moiety allowed for anodic oxidation to be performed without supporting electrolyte. The mediator salt can be easily recovered and reused. Our "ex-cell" approach toward the electrosynthesis of benzoxazoles is compatible with a range of redox-sensitive functional groups. An unprecedented concerted reductive elimination mechanism for benzoxazole formation is proposed on the basis of control experiments and DFT calculations.

N-Heterocyclic carbene copper(i) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles

A new and efficient synthesis of 2-arylbenzoxazoles and benzothiazoles using a copper N-heterocyclic carbene complex is described. In a simple protocol a variety of 2-substituted benzoxazoles and benzothiazoles were obtained via intramolecular coupling cyclization of 2-haloanilides/2-halothioanilides in good to excellent yields.

Amberlyst-15-catalyzed synthesis of 2-substituted 1,3-benzazoles in water under ultrasound

A clean and general method has been developed for the synthesis of benzothiazole, benzoxazole, and benzimidazoles using Amberlyst-15 as a recyclable catalyst under ultrasound irradiation in water. The methodology is operationally simple, free from the use of hazardous organic solvents, and does not require the use of inert or anhydrous atmosphere. A number of 1,3-benzazole derivatives were prepared in good to excellent yields by using this methodology.

The efficient o-benzenedisulfonimide catalysed synthesis of benzothiazoles, benzoxazoles and benzimidazoles

O-Benzenedisulfonimide has been used to efficiently catalyse the reaction between 2-aminothiophenol, 2-aminophenol, o-phenylenediamine and various ortho esters (28 examples; average yield 90%) or aldehydes (17 examples; average yield 72%) giving the corresponding benzofused azoles in excellent yields. Reaction conditions were very simple. In addition, other carboxylic acid derivatives have been tested and gave good results. The catalyst was easily recovered and reused. ARKAT-USA, Inc.