31904-34-4Relevant articles and documents
Synthetic method of Ugi's amines and derivatives of Ugi's amines
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Paragraph 0083-0092, (2019/05/16)
The invention discloses a synthetic method of Ugi's amines and derivatives of the Ugi's amines represented by a formula (I) shown in the description. The method comprises the following steps: performing reductive amination by using ferrocene and a derivative of the ferrocene as raw materials to obtain a racemic primary amine, performing resolution on the racemic primary amine by a resolving agentto obtain an optical isomer primary amine, performing an alkylation or reductive amination reaction on the optical isomer primary amine to obtain one Ugi's amine and the derivative of the Ugi's amine.The chiral Ugi's amines and the derivatives of the Ugi's amines provided by the invention can be used to synthesize a series of Josiphos-like ferrocene bisphosphine ligands, the Josiphos-like ferrocene bisphosphine ligands are used as chiral ligands for various metal complex catalysts, are important chiral catalyst ligands for preparation of pharmaceutical intermediates and agrochemicals, have awide range of applications in metal catalysis asymmetric reactions, and are suitable for industrialized large-scale production; and the reaction conditions are mild, the raw materials are cheap and easy to obtain, the synthetic route is simple, and the yield and chiral purity are higher.
FUNCTIONALIZED MAGNETIC NANOPARTICLE, A CATALYST, A METHOD FOR FORMING C-C BONDS
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Paragraph 0194, (2018/04/20)
A functionalized magnetic nanoparticle including an organometallic sandwich compound and a magnetic metal oxide. The functionalized magnetic nanoparticle may be reacted with a metal precursor to form a catalyst for various C—C bond forming reactions. The catalyst may be recovered with ease by attracting the catalyst with a magnet.
Rhodium-Catalyzed Asymmetric Allylation of Malononitriles as Masked Acyl Cyanide with Allenes: Efficient Access to β,γ-Unsaturated Carbonyls
Grugel, Christian P.,Breit, Bernhard
supporting information, p. 15223 - 15226 (2018/09/25)
A rhodium-catalyzed regio- and enantioselective intermolecular allylation of malononitriles as masked acyl cyanides (MAC) with terminal and symmetrical internal allenes is reported. A RhI/Josiphos catalytic system combined with subsequent oxidative degradation of the primary adducts enables a straightforward access to α-branched, β,γ-unsaturated carbonyl compounds. The present protocol exhibits perfect atom economy in the allylation step and is characterized by a great functional group compatibility. Furthermore, the use of α-substituted malononitriles allowed for the construction of all-carbon quaternary centers.
