31952-55-3

Usage

Uses

Used in Pharmaceutical Industry:
4,4-Dimethyl-4H-isochromene-1,3-dione is used as a pharmaceutical compound for its anti-inflammatory and analgesic properties, making it a potential candidate for the treatment of various medical conditions.
Used in Agricultural Industry:
4,4-Dimethyl-4H-isochromene-1,3-dione is used as an insecticide and antifungal agent due to its reported insecticidal and antifungal activities, making it of interest for agricultural and pesticidal applications.
Used in Organic Synthesis:
4,4-Dimethyl-4H-isochromene-1,3-dione is used as a reagent in organic synthesis, contributing to the development of new chemical compounds and materials.

Upstream product

• 40463-15-8 1,1,4-trimethyl-tetralin 
• 40484-15-9 α,α-dimethylhomophthalic acid 
• 26465-81-6 3,3-dimethylindan-1-one 
• 2979-70-6 2-methyl-5-phenyl-2-pentanol 
• 1985-59-7 1,1-dimethyltetralin 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 201230-82-2 carbon monoxide 
• 1462-75-5 3-phenylpropylmagnesium bromide 
• 1010-48-6 3-methyl-3-phenylbutanoic acid 
• 4397-05-1 2,4-dimethyl-3-phenylpentan-3-ol 
• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 479029-86-2 2-([2H₃]methyl)-4-methyl-4-phenyl[1,1,1-2H₃]pentan-3-ol 
• 91496-41-2 2-(1,1-dimethyl-2-oxopropyl)benzoic acid 
• 71-43-2 benzene 

Downstream Products

• 40484-15-9 α,α-dimethylhomophthalic acid 
• 1689-09-4 3,3-Dimethyl-3H-isobenzofuran-1-one 
• 23417-79-0 2-(1-methylethenyl)benzaldehyde 
• 98-82-8 Isopropylbenzene 

Relevant academic research and scientific papers

Compositions and methods for the protection of nucleophilic groups

The present invention provides compositions, methods, and kits relating to the protection and deprotection of molecules comprising nucleophilic groups, such as the protection and deprotection of thermostable polymerases. Also provided are methods of performing nucleic acid amplification using polymerases protected according to the invention.

Synthesis of 1,2- and 1,3-dicarboxylic acids via Pd(II)-catalyzed carboxylation of aryl and vinyl C-H bonds

A Pd(II)-catalyzed reaction protocol for the direct carboxylation of benzoic and phenylacetic acid derivatives to form dicarboxylic acids has been developed. The reaction conditions are also applicable for the carboxylation of vinyl C-H bonds. The first C-H insertion Pd-aryl complex from carboxylic acids has been characterized by X-ray crystallography. Copyright

On rearrangements by cyclialkylations of arylpentanols to 2,3-dihydro-1H-indene derivatives. Part 2. An unexpected rearrangement by the acid-catalyzed cyclialkylation of 2,4-dimethyl-2-phenylpentan-3-ol under formation of trans-2,3-dihydro-1,1,2,3-tetramethyl-1H-indene

The acid catalyzed-cyclialkylation of 4-(2-chloro-phenyl)-2,4-dimethylpentan-2-ol (1) gave two products: 4-chloro-2,3-dihydro-1,1,3,3-tetramethyl-1H-indene (2) and also trans-4-chloro-2,3-dihydro-1,1,2,3-tetramethyl-1H-indene (3). A mechanism was proposed in Part 1 (cf. Scheme 1) for this unexpected rearrangement. This mechanism would mainly be supported by the result of the cyclialkylation of 2,4-dimethyl-2-phenylpentan-3-ol (4), which, with respect to the similarity of ion II in Scheme I and ion V in Scheme 2, should give only product 5. This was indeed the experimental result of this cyclialkylation. But the result of the cyclialkylation of 1,1,1,2′,2′,2′-hexadeuterated isomer [2H6]-4 of 4 (cf. Scheme 3) requires a different mechanism as for the cyclialkylation of 1. Such a mechanism is proposed in Schemes 5 and 6. It gives a satisfactory explanation of the experimental results and is supported by the result of the cyclialkylation of 2,4-dimethyl-3-phenylpentan-3-ol (9; Scheme 7). The alternative migration of a Ph or of an i-Pr group (cf. Scheme 6) is under further investigation.

Stereopopulation Control. 8. Rate and Equilibrium Enhancement in the Formation of Homophthalic Anhydrides

The kinetics of cyclization of α,α,3,4,6-pentamethylhomophthalic acid have been measured in sovent acetonitrile at 28.5 deg C, using as catalysts a series of acids ranging in strength from perchloric to acetic.In the presence of 0.12 M HClO4, t1/2 for acid anhydride formation = 0.3 s.For the stronger acid catalysts, kcycl is a linear function of catalyst concentration; for the weak acids, however, a change in rate-limiting step is revealed by curvature in the plots of ktotobsd vs. .All the weak acids show the same limiting value, 6.45E-3 min-1; this value is considered to be the rate constant for uncatalyzed formation of the tetrahedral intermediate.Homoconjugate bases (HA2(-)) of the weak acids show a similar curvature in their dilution plots, and the same limiting rate constant as for weak acids.Two independent and competitive pathways for cyclization are proposed.For strong acid catalysis, an intermediate acylium ion is considered on the basis of Broensted α = -0.79, kH/kD ca. 1, and acceleration of anhydride hydrolysis by methyl substituents.A value of ΔSexcit. = -23 eu suggests that cyclization, rather than acylium ion formation, is rate limiting.For weak acid catalysis, α = -0.17, kH/kD = 4.3, ΔSexcit. = -31 eu, and methyl groups retard anhydride hydrolysis by electron release; for this pathway, catalyzed breakdown of a tetrahedral intermediate is considered rate limiting.The composite Broensted plot is curved because the two pathways follow different rate laws.In contrast to rate enhancement results for phenolic lactone formation, the pentamethylhomophthalic acid is only sevenfold as reactive as α,α-dimethylhomophthalic acid.For the catalyst acids, pK(acetonitrile) is shown to be a linear function of pK(H2O) over the entire range of acids examined.