31991-79-4

Upstream product

• 462-94-2 1,5-diaminopentane 
• 98-88-4 benzoyl chloride 
• 93-99-2 benzoic acid phenyl ester 
• 32513-92-1 Nα,ε-dibenzoyl-D,L-lysine 
• 1476-39-7 1,5-diaminopentane dihydrochloride 
• 6958-80-1 NN'-di(benzylidene)-1,5-diaminopentane 
• 65-85-0 benzoic acid 
• 100-52-7 benzaldehyde 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 628-76-2 1,5-dichloropentane 
• 100-47-0 benzonitrile 
• 93300-58-4 C₂₁H₂₆N₂O₂ 

Relevant academic research and scientific papers

Inclusion compound of β-cyclodextrin with binuclear guests containing residues of some pharmocologically important aromatic monocarboxylic acids

Stable monomeric and dimeric inclusion compounds of β-cyclodextrin with binuclear guests containing the residues of some pharmacologically important aromatic monocarboxylic acids were obtained. Pleiades Publishing, Ltd., 2011.

Synthesis of amide libraries with immobilized HOBt

Highly reactive N-acylating solid-phase reagents based on macroporous polystyrene-bound 1-hydroxybenzotriazole (P-HOBt) and silica-bound 1-hydroxybenzotriazole (Si-HOBt) were prepared and compared for reactivity by synthesis of small combinatorial libraries of acetamides and benzamides.

Selective Monoacylation of Symmetrical Diamines via Prior Complexation with Boron

(Equation presented) Pretreatment of a symmetrical primary or secondary diamine with 9-BBN prior to the addition of an acyl chloride significantly suppressed undesired diacylation, and the product of monoacylation predominated. The reactive preference is interpreted as the result of a selective deactivation of one nitrogen atom of the diamine by 9-BBN.

HOBT immobilized on macroporous polystyrene beads: A useful reagent for the synthesis of amides

Polymer-supported 1-hydroxybenzotriazole (P-HOBT), prepared from macroporous polystyrene beads, was used to synthesize amides from primary and secondary amines.

ROTATION ISOMERISM OF N,N'-DIMETHYL-α,ω-BIS(BENZOYLAMINO)ALKANES

The kow-temperature 1H n.m.r. spectra of PhCON(Me)(CH2)nN(Me)COPh show four signals for ht e methyl groups when n 3, which are atributable to the presence of three rotational isomers.Only one isomer was detectable over a wide temperature range when n

(2)H NMR SPECTROSCOPY AS A PROBE OF THE STEREOCHEMISTRY OF ENZYMIC REACTIONS AT PROCHIRAL CENTRES DIAMINE OXIDASE

In the conversion of cadaverine into Δ1-piperideine, of putrescine into Δ1-pyrroline, and of agmatine into 4-guanidinobutanal, catalyzed by hog kidney diamine oxidase (DAO) (E.C. 1.4.3.6 diamine:oxygen oxidoreductase (deaminating)), the si-H from C-1 of the substrate is removed while the re-H from C-1 of the substrate is maintained at the sp2 C atom of each of the products. DAO catalyzed oxidation of cadaverine takes place without detectable isotope effect, while an intramolecular primary isotope effect (kHsi/kDsi =4) is observed in the DAO catalyzed oxidation of putrescine. In conflict with earlier reports, incubation of cadaverine in deuterium oxide in the presence of bacterial L-lysine decarboxylase (E.C. 4.1.1.18) did not lead to entry of deuterium into the α-position of cadaverine.Likewise, L-ornithine decarboxylase (E.C. 4.1.1.17) did not catalyze exchange of the α-H of putrescine, nor did L-arginine decarboxylase (E.C. 4.1.1.19) catalyze such an exchange in agmatine.

KINETICS AND MECHANISM OF ACID HYDROLYSIS OF N-BENZOYL-L-LYSINES

Minor differences in acid hydrolysis rates of α- and ε-amide bonds in corresponding N-benzoyl-L-lysines have been found.The reaction is accelerated in the presence of free carboxyl group in the lysine-derivative molecule.The acid dissociation constants KAH of N - and Nε-benzoyl-L-lysines have been determined.Also the substituent effect in benzoyl group on the reaction rate has been examined.A mechanism of the acid hydrolysis of acyl derivatives of lysine is proposed.