32149-27-2

Basic information

• Product Name: 2-Butenoic acid, 4-(4-bromophenyl)-4-oxo-, methyl ester, (E)-
• CAS NO: 32149-27-2
• Molecular Formula: C11H9BrO3
• Molecular Weight: 269.095
• Mol File: 32149-27-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 4-(4-bromophenyl)-4-oxo-, methyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 4-(4-bromophenyl)-4-oxo-, methyl ester, (E)-(32149-27-2)
• EPA Substance Registry System: 2-Butenoic acid, 4-(4-bromophenyl)-4-oxo-, methyl ester, (E)-(32149-27-2)

Safety Data

• Hazardous Substances Data: 32149-27-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 20972-38-7 (E)-4-(4-bromophenyl)-4-oxobut-2-enoic acid 
• 186581-53-3 diazomethane 
• 67-66-3 chloroform 
• 32095-83-3 4-oxo-4-(4-bromo-phenyl)-cis-crotonic acid methyl ester 
• 7553-56-2 iodine 
• 108-86-1 bromobenzene 
• 60112-46-1 (E)-methyl 4-(4-bromophenyl)-4-hydroxy-but-2-enoate 
• 58824-56-9 1-(p-bromophenyl)prop-2-en-1-ol 
• 1122-91-4 4-bromo-benzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 7477-66-9 4-oxo-4-(4-bromo-phenyl)-trans-crotonic acid-chloride 

Downstream Products

• 123676-83-5 3-(4-Bromo-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 
• 123676-82-4 methyl 3-(4-bromobenzoyl)-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthalenecarboxylate 
• 30913-86-1 4-(4-bromo-phenyl)-4-oxo-butyric acid methyl ester 
• 32095-83-3 4-oxo-4-(4-bromo-phenyl)-cis-crotonic acid methyl ester 

Relevant articles and documents

Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents

A series of novel (E)-4-oxo-2-crotonamide derivatives were designed and synthesized to find potent antituberculosis agents. All the target compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv(MTB). Results reveal that 4-phenyl moiety at part A and short methyl group at part C were found to be favorable. Most of the derivatives displayed promising activity against MTB with MIC ranging from 0.125 to 4 μg/mL. Especially, compound IIIa16 was found to have the best activity with MIC of 0.125 μg/mL against MTB and with MIC in the range of 0.05–0.48 μg/mL against drug-resistant clinical MTB isolates.

Grubbs cross-metathesis pathway for a scalable synthesis of γ-keto-α,β-unsaturated esters

A direct and scalable route to γ-keto-α,β-unsaturated esters, useful intermediates in medicinal chemistry and natural products synthesis, is reported. The key step involves the use of Grubbs' second-generation olefin metathesis catalyst for cross-metathes