3299-62-5

Basic information

• Product Name: o-Oxalotoluidide
• Synonyms: o-Oxalotoluidide;N,N'-Bis(2-Methylphenyl)ethanediaMide;N,N'-Bis(o-tolyl)oxaMide;N1,N2-Bis(2-Methylphenyl)ethanediaMide;NSC 11023;N,N'-DI(O-TOLYL)OXAMIDE;N1,N2-Di-o-tolyloxalamide
• CAS NO: 3299-62-5
• Molecular Formula: C₁₆H₁₆N₂O₂
• Molecular Weight: 268.31044
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 3299-62-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 215 °C
• Appearance: /
• Density: 1.241±0.06 g/cm3(Predicted)
• PKA: 11.11±0.70(Predicted)
• CAS DataBase Reference: o-Oxalotoluidide(CAS DataBase Reference)
• NIST Chemistry Reference: o-Oxalotoluidide(3299-62-5)
• EPA Substance Registry System: o-Oxalotoluidide(3299-62-5)

Safety Data

• Hazardous Substances Data: 3299-62-5(Hazardous Substances Data)

Upstream product

• 144-62-7 oxalic acid 
• 95-53-4 o-toluidine 
• 135850-46-3 N,N'-bis(2-methylphenyl)ethane-bis(imidoyl) dichloride 
• 64-19-7 acetic acid 
• 95-92-1 oxalic acid diethyl ester 
• 1619-73-4 ethyl 2-oxo-4-phenylbut-3-ynoate 
• 79-37-8 oxalyl dichloride 
• 37600-45-6 4-(o-toluidino)-4-oxobutanoic acid 
• 124-38-9 carbon dioxide 
• 406190-09-8 N-(o-tolyl)-oxamic acid 
• 7664-93-9 sulfuric acid 

Downstream Products

• 120-72-9 indole 
• 135850-46-3 N,N'-bis(2-methylphenyl)ethane-bis(imidoyl) dichloride 
• 861011-90-7 N,N'-bis-(2-methyl-4,6-dinitro-phenyl)-oxalamide 
• 617-07-2 N,N'-bis(2-methylphenyl)urea 
• 570-24-1 2-Methyl-6-nitroaniline 
• 13208-96-3 7-methylisatin-3-oxime 
• 1127-59-9 7-methyl-1H-indole-2,3-dione 

Relevant articles and documents

Synthesis of new N-pyrrolylphosphane and its application in hydroformylation of 1-octene

A new bidentate N-pyrrolylphosphane (1) which possessing strong π-acceptor property has been synthesized and applied in homogeneous rhodium-catalyzed hydroformylation of 1-octene. The effects of ligand/metal ratio, temperature, pressure and substrate/rhod

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Highly productive α-alkylation of ketones with alcohols mediated by an Ir-oxalamidato/solid base catalyst system

An Ir-oxalamidato complex in combination with a solid base (e.g., magnesium aluminometasilicate/Ca(OH)2) significantly improved the catalyst productivity in α-alkylation of methyl ketones with primary alcohols. Optimization through systematic variation of the oxalamidato ligand led to a practical turnover number (TON) of 10 000.40 000.

CO-use CO2 Method for synthesizing N, N - dialkyl oxalate

The invention provides a method for synthesizing N,N-dialkyl oxamide by using CO2. According to the method, in an organic or inorganic solvent, one-step synthetic reaction is performed on the CO2 and organic amine to synthesize the N,N-dialkyl oxamide, with N,N-dialkyl urea and water as byproducts, in the presence of a certain catalyst and under a certain reaction condition that the reaction pressure is 10-80atm and the reaction temperature is 100-200 DEG C. The invention discloses the method for synthesizing the N,N-dialkyl oxamide by using the CO2. According to the method, a valuable and toxic metal catalyst and a toxic and explosive gas in the prior art are not used, and reactants, products, and added components in a system are safe and environment-friendly; the yield is considerable; technically, an improvement room exists; a safe and environment-friendly new method is provided for preparing the N,N-dialkyl oxamide.