33046-48-9

Usage

Uses

Used in Pharmaceutical Industry:
α-(4-Nitrophenylthio)acetophenone is used as a starting material for the synthesis of various pharmaceutical compounds due to its unique chemical properties. The presence of the nitro group allows for further chemical modifications, enabling the development of new drugs with potential therapeutic applications.
Used in Dye Industry:
α-(4-Nitrophenylthio)acetophenone is used as a precursor in the synthesis of dyes, taking advantage of its yellow crystalline properties. α-(4-Nitrophenylthio)acetophenone can be modified to produce a range of colors, making it a valuable component in the dye industry.
Used in Specialty Chemicals:
α-(4-Nitrophenylthio)acetophenone is used in the preparation of specialty chemicals, such as agrochemicals and fragrances, due to its unique chemical properties. α-(4-Nitrophenylthio)acetophenone can be further modified to create specific chemical structures, enhancing its utility in various applications.
Used in Antibacterial Applications:
α-(4-Nitrophenylthio)acetophenone is used as an antibacterial agent, exhibiting activity against various types of bacteria. Its potential use in medicine and biotechnology can contribute to the development of new antimicrobial agents to combat bacterial infections.
Used in Antifungal Applications:
α-(4-Nitrophenylthio)acetophenone is used as an antifungal agent, showing activity against different types of fungi. Its potential applications in the field of medicine and biotechnology can aid in the development of new antifungal agents to treat fungal infections.

InChI:InChI=1/C14H11NO3S/c16-14(11-4-2-1-3-5-11)10-19-13-8-6-12(7-9-13)15(17)18/h1-9H,10H2

Upstream product

• 532-27-4 1-chloroacetophenone 
• 824-78-2 4-nitrophenol sodium salt 
• 13113-79-6 sodium 4-nitrobenzenethiolate 
• 937-32-6 4-nitrobenzenesulfenyl chloride 
• 98-86-2 acetophenone 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 70-11-1 α-bromoacetophenone 
• 1849-36-1 para-nitrobenzenethiol 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 98-88-4 benzoyl chloride 
• 536-74-3 phenylacetylene 
• 16717-64-9 1-azidostyrene 

Downstream Products

• 111441-02-2 1-[α-(4-nitro-phenylsulfanyl)-phenacyl]-pyridinium; iodide 
• 41024-48-0 2-((4-nitrophenyl)sulfonyl)-1-phenylethan-1-one 
• 99036-59-6 ω-Phenylmercapto-ω-(4-nitro-phenylmercapto)-acetophenon 
• 24257-90-7 phenyl-glyoxal-bis-(4-nitro-phenylhydrazone) 
• 1248588-14-8 3-ethoxy-2-[(4-nitrophenyl)sulfanyl]-1-phenylprop-2-en-1-one 
• 19822-16-3 Benzoyl-(4-nitro-phenylsulfonyl)-(triphenylphosphoranyliden-hydrazono)-methan 
• 19822-15-2 Benzoyl-(4-nitro-phenylsulfonyl)-diazomethan 
• 31599-06-1 (E)-1-((2-chloro-2-phenylvinyl)sulfonyl)-4-nitrobenzene 
• 332347-28-1 1-chloro-(E)-2-(p-nitrophenylthio)-1-phenylethylene 

Relevant academic research and scientific papers

An aryl thiol-vinyl azide coupling reaction and a thiol-vinyl azide coupling/cyclization cascade: efficient synthesis of β-ketosulfides and arene-fused 5-methylene-2-pyrrolidinone derivatives

The addition reaction of thiol to vinyl azide has been extensively studied. Variously substituted aryl thiols are all viable for this coupling process. The scope of the other partner is successfully expanded from α-aryl vinyl azide to α-alkyl vinyl azide.

Catalyst-Free Insertion of Sulfoxonium Ylides into Aryl Thiols. A Direct Preparation of β-Keto Thioethers

Insertion of sulfoxonium ylides into the S-H bond of aryl thiols without the need for a catalyst is demonstrated, furnishing β-keto thioethers in excellent yield in most cases. The method overcomes traditional syntheses that employ metal catalysts in combination with diazo compounds or toxic and hard-prepared haloketones. The experimental setup consists of mixing the reagents in acetonitrile at room temperature. Additional experimental as well as kinetic isotopic effect studies give some insight into the mechanism of this reaction.

Regioselective synthesis of 5-(arylsulfanyl)- and 5-(benzylsulfanyl)-6- phenylsalicylates by one-pot cyclizations of 1,3-bis(silyloxy)buta-1,3-dienes with 2-(arylsulfanyl)- and 5-(benzylsulfanyl)-3-ethoxy-1-phenylprop-2-en-1-ones

5-(Arylsulfanyl)-6-phenylsalicylates were prepared by one-pot cyclizations of 1,3-bis(trimethylsilyloxy) buta-1,3-dienes with 2-(arylsulfanyl)-3-ethoxy-1- phenylprop-2-en-1-ones.

Sulfite-promoted one-pot synthesis of sulfides by reaction of aryl disulfides with alkyl halides

A sodium dithionite, sodium thiosulfate and rongalite promoted one-pot synthesis of aryl alkyl sulfides at room temperature has been developed. The reactions of a range of disulfides with alkyl halides proceeded smoothly in the presence of rongalite. Possible reaction pathways are discussed and the effects of these sulfites on disulfides are investigated. The important features of this protocol are metal-free, strong-base-free, and mild reaction conditions, operational simplicity, short reaction times and high yields of products. Georg Thieme Verlag Stuttgart.

One-pot synthesis of sulfides by reaction of disulfides with alkyl halides in the presence of sodium dithionite

Sodium dithionite-promoted synthesis of unsymmetrical diorganyl sulfides by a reaction of diaryl disulfides with alkyl halides at r.t. has been developed. The advantages offered by this method are operational simplicity, a faster reaction, neutral and mild reaction conditions, and moderate to good yields of products.