3328-68-5

Usage

Uses

Used in Organic Synthesis:
5-Chloro-2-Hydroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde) is used as a key intermediate in the synthesis of various organic compounds. Its unique structure, which includes a chlorine atom, hydroxy group, and aldehyde functional group, makes it a versatile building block for the creation of a wide range of chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Chloro-2-Hydroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde) is used as a starting material for the development of new drugs. Its chemical properties allow for the formation of diverse molecular structures, which can be further modified to create potential therapeutic agents.
Used in Agrochemical Industry:
5-Chloro-2-Hydroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde) is also utilized in the agrochemical industry for the synthesis of various agrochemical products, such as pesticides and herbicides. Its reactivity and functional groups enable the creation of compounds with specific target effects on pests and weeds.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 5-Chloro-2-Hydroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde) is employed as a precursor for the production of dyes and pigments. Its chemical structure can be manipulated to yield a range of colors and properties, making it a valuable component in the formulation of various colorants.
Used in Flavor and Fragrance Industry:
5-Chloro-2-Hydroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde) is used as a raw material in the flavor and fragrance industry to create unique scents and flavors. Its aromatic properties allow for the development of novel fragrances and flavorings, contributing to the diversity of products in this sector.

InChI:InChI=1/C8H7ClO2/c1-5-2-8(11)6(4-10)3-7(5)9/h2-4,11H,1H3

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 67-66-3 chloroform 
• 100-97-0 hexamethylenetetramine 
• 15733-22-9 4-chloro-3-methyl phenol, sodium salt 
• 3411-03-8 3-Chlor-4-methyl-benzaldehyd 

Downstream Products

• 215124-37-1 N,N-dimethyl-O-(4-chloro-2-formyl-5-methylphenyl)thiocarbamate 
• 1204655-61-7 C₁₅H₁₂BrClO₂ 
• 1413932-73-6 (E)-3-(5-chloro-2-hydroxy-4-methylphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Pd-Catalyzed Ortho C-H Hydroxylation of Benzaldehydes Using a Transient Directing Group

The direct Pd-catalyzed ortho C-H hydroxylation of benzaldehydes was achieved using 4-chloroanthranilic acid as the transient directing group, 1-fluoro-2,4,6-trimethylpyridnium triflate as the bystanding oxidant, and p-toluenesulfonic acid as the putative oxygen nucleophile. The unusual C-H chlorination and polyfluoroalkoxylation reactions signaled the importance of external nucleophiles to the outcome of Pd(IV) reductive eliminations.

Palladium(0)-catalyzed intramolecular heck reaction: A resourceful route for the synthesis of naphthoxepine naphthoxocine derivatives

The synthesis of oxocines and oxepines is difficult. Two efficient protocols have been developed for the construction of naphthoxepine and naphthoxocine derivatives by sequential Wittig olefination and intramolecular Heck reaction. Georg Thieme Verlag Stuttgart.

BENZOPYRAN COMPOUNDS USEFUL FOR TREATING INFLAMMATORY CONDITIONS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (1). Wherein Z, X, R1, R2, R3, and R4 are as described in specification.

CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (I). Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.