33609-48-2

Usage

Uses

Used in Organic Chemistry:
(3,4-dinitrophenyl)(phenyl)methanone is used as a reagent for the detection and identification of aldehydes and ketones. It reacts with these functional groups to form a colored precipitate, which facilitates easy visualization and confirmation of the presence of aldehydes and ketones in a given sample.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (3,4-dinitrophenyl)(phenyl)methanone is used as a precursor for the synthesis of various pharmaceuticals. Its role in the production process is crucial for creating the desired medicinal compounds.
Used in Dye Intermediates Synthesis:
(3,4-dinitrophenyl)(phenyl)methanone is also utilized as a precursor in the synthesis of dye intermediates. Its chemical properties make it a valuable component in the creation of a range of dyes used in different applications.
Safety Precautions:
Due to its toxic nature, it is important to handle (3,4-dinitrophenyl)(phenyl)methanone with care. Proper safety measures, including the use of personal protective equipment (PPE) such as gloves, goggles, and masks, should be taken to minimize the risk of skin, eye, and respiratory irritation. Additionally, it is crucial to follow proper disposal and storage procedures to prevent accidental exposure or contamination.

Upstream product

• 528-45-0 3,4-dinitrobenzoic acid 
• 71-43-2 benzene 
• 39070-63-8 4-benzoylbenzene-1,2-diamine 
• 610-39-9 3,4-Dinitrotoluene 
• 6971-33-1 4-methyl-2-nitro-1-nitrosobenzene 
• 24376-18-9 3,4-dinitrobenzoyl chloride 
• 89-62-3 4-methyl-2-nitroaniline 

Downstream Products

• 39070-63-8 4-benzoylbenzene-1,2-diamine 
• 57070-71-0 (3,4-diaminophenyl)phenylmethanone hydrochloride 
• 119426-73-2 (2,3-dimethylquinoxalin-6-yl)(phenyl)methanone 
• 150252-47-4 6-benzoyl-2,3-diphenylquinoxaline 
• 216387-91-6 phenyl(2,3-diphenyl-6-quinoxalinyl)carbinol 
• 134859-18-0 11-benzoyldibenzophenazine 
• 31431-39-7 mebendazole 

Relevant academic research and scientific papers

Design and synthesis of a novel candidate compound NTI-007 targeting sodium taurocholate cotransporting polypeptide [NTCP]-APOA1-HBx-Beclin1-mediated autophagic pathway in HBV therapy

Sodium taurocholate cotransporting polypeptide (NTCP) is a multiple transmembrane transporter predominantly expressed in the liver, functioning as a functional receptor for HBV. Through our continuous efforts to identify NTCP as a novel HBV target, we designed and synthesized a series of new compounds based on the structure of our previous compound NT-5. Molecular docking and MD simulation validated that a new compound named NTI-007 can tightly bind to NTCP, whose efficacy was also measured in vitro virological examination and cytotoxicity studies. Furthermore, autophagy was observed in NTI-007 incubated HepG2.2.15 cells, and results of q-PCR and Western blotting revealed that NTI-007 induced autophagy through NTCP-APOA1-HBx-Beclin1-mediated pathway. Taken together, considering crucial role of NTCP in HBV infection, NTCP-mediated autophagic pathway may provide a promising strategy of HBV therapy and given efficacy of NTI-007 triggering autophagy. Our study suggests pre-clinical potential of this compound as a novel anti-HBV drug candidate.

A Fast, High-Yield Preparation of Vicinal Dinitro Compounds Using HOF·CH3CN

HOF·CH3CN, a very efficient oxygen-transfer agent, was reacted with various aliphatic and aromatic vicinal diamino compounds. The products were the rare, vicinal dinitro derivatives formed in excellent yields and short reaction times. This is in contrast to other oxygen-transfer agents which tend to break the central C-C bond of the diamino precursor. This reaction was also used for making dinitro compounds with all four oxygens, being the [18]O isotope.

6-Lithioquinoxalines and Their Transformations

6-Bromo-2,3-diphenylquinoxaline reacts with butyllithium to give the 6-lithio derivative in a yield of more than 80%, which reacts with electrophiles such as benzophenone, Michler ketone, methyl ethyl ketone, iodine, selenium, and dimethylformamide to give the corresponding quinoxaline derivatives. 6-Bromo-2,3-dimethylquinoxaline is metallated with butyl- and phenyllithium at the methyl groups and benzene ring. These organolithium compounds react with benzophenone to give the corresponding diphenyl- and triaryl-carbinols, whose yield and ratio were determined by HPLC. These results open prospects for preparing new quinoxaline derivatives substituted at the annelated benzene ring.