33609-48-2

Basic information

• Product Name: (3,4-dinitrophenyl)(phenyl)methanone
• CAS NO: 33609-48-2
• Molecular Formula: C₁₃H₈N₂O₅
• Molecular Weight: 272.213
• Mol File: 33609-48-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 483°C at 760 mmHg
• Flash Point: 245.2°C
• Density: 1.423g/cm³
• Vapor Pressure: 1.74E-09mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: (3,4-dinitrophenyl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-dinitrophenyl)(phenyl)methanone(33609-48-2)
• EPA Substance Registry System: (3,4-dinitrophenyl)(phenyl)methanone(33609-48-2)

Safety Data

• Hazardous Substances Data: 33609-48-2(Hazardous Substances Data)

Usage

General Description

"(3,4-dinitrophenyl)(phenyl)methanone" is a chemical compound with the formula C13H9N3O5. It is a yellow, crystalline substance that is insoluble in water. (3,4-dinitrophenyl)(phenyl)methanone is commonly used as a reagent in organic chemistry for the detection and identification of aldehydes and ketones. It undergoes a chemical reaction with these functional groups to form a colored precipitate, which allows for easy visualization and confirmation of the presence of aldehydes and ketones in a given sample. Additionally, it is used as a precursor for the synthesis of various pharmaceuticals and dye intermediates. However, it is important to handle this compound with care, as it is toxic and may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 24376-18-9 3,4-dinitrobenzoyl chloride 
• 71-43-2 benzene 
• 528-45-0 3,4-dinitrobenzoic acid 
• 89-62-3 4-methyl-2-nitroaniline 
• 6971-33-1 4-methyl-2-nitro-1-nitrosobenzene 
• 610-39-9 3,4-Dinitrotoluene 
• 39070-63-8 4-benzoylbenzene-1,2-diamine 

Downstream Products

• 119426-73-2 (2,3-dimethylquinoxalin-6-yl)(phenyl)methanone 
• 150252-47-4 6-benzoyl-2,3-diphenylquinoxaline 
• 216387-91-6 phenyl(2,3-diphenyl-6-quinoxalinyl)carbinol 
• 134859-18-0 11-benzoyldibenzophenazine 
• 31431-39-7 mebendazole 
• 57070-71-0 (3,4-diaminophenyl)phenylmethanone hydrochloride 
• 39070-63-8 4-benzoylbenzene-1,2-diamine 

Relevant articles and documents

Design and synthesis of a novel candidate compound NTI-007 targeting sodium taurocholate cotransporting polypeptide [NTCP]-APOA1-HBx-Beclin1-mediated autophagic pathway in HBV therapy

Sodium taurocholate cotransporting polypeptide (NTCP) is a multiple transmembrane transporter predominantly expressed in the liver, functioning as a functional receptor for HBV. Through our continuous efforts to identify NTCP as a novel HBV target, we designed and synthesized a series of new compounds based on the structure of our previous compound NT-5. Molecular docking and MD simulation validated that a new compound named NTI-007 can tightly bind to NTCP, whose efficacy was also measured in vitro virological examination and cytotoxicity studies. Furthermore, autophagy was observed in NTI-007 incubated HepG2.2.15 cells, and results of q-PCR and Western blotting revealed that NTI-007 induced autophagy through NTCP-APOA1-HBx-Beclin1-mediated pathway. Taken together, considering crucial role of NTCP in HBV infection, NTCP-mediated autophagic pathway may provide a promising strategy of HBV therapy and given efficacy of NTI-007 triggering autophagy. Our study suggests pre-clinical potential of this compound as a novel anti-HBV drug candidate.

6-Lithioquinoxalines and Their Transformations

6-Bromo-2,3-diphenylquinoxaline reacts with butyllithium to give the 6-lithio derivative in a yield of more than 80%, which reacts with electrophiles such as benzophenone, Michler ketone, methyl ethyl ketone, iodine, selenium, and dimethylformamide to give the corresponding quinoxaline derivatives. 6-Bromo-2,3-dimethylquinoxaline is metallated with butyl- and phenyllithium at the methyl groups and benzene ring. These organolithium compounds react with benzophenone to give the corresponding diphenyl- and triaryl-carbinols, whose yield and ratio were determined by HPLC. These results open prospects for preparing new quinoxaline derivatives substituted at the annelated benzene ring.