150252-47-4

Upstream product

• 39070-63-8 4-benzoylbenzene-1,2-diamine 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 134-81-6 benzil 
• 619-05-6 3,4-diaminobenzoic acid 
• 89-62-3 4-methyl-2-nitroaniline 
• 6971-33-1 4-methyl-2-nitro-1-nitrosobenzene 
• 610-39-9 3,4-Dinitrotoluene 
• 33609-48-2 3,4-dinitrobenzophenone 
• 528-45-0 3,4-dinitrobenzoic acid 
• 216387-73-4 6-bromo-2,3-diphenylquinoxaline 
• 100-52-7 benzaldehyde 
• 216387-91-6 phenyl(2,3-diphenyl-6-quinoxalinyl)carbinol 

Downstream Products

• 216387-91-6 phenyl(2,3-diphenyl-6-quinoxalinyl)carbinol 

Relevant academic research and scientific papers

SO3H-functionalized metal organic frameworks: An efficient heterogeneous catalyst for the synthesis of quinoxaline and derivatives

An efficient alkylsulfonate functionalized metal organic framework (MOF), MIL-101-Cr-NH-RSO3H, has been successfully synthesized through a post-synthetic modification strategy of MIL-101-Cr-NH2 with 1,3-propanesultone reagent. The high surface area of the MIL-101-Cr-NH2 MOF guaranteed the high dispersion of -SO3H active species and the large pore size improved the contacting ability between the substrate and these active sites. The solid MIL-101-Cr-NH-RSO3H catalyst exhibited high catalytic performance in the preparation of quinoxaline derivatives by the condensation of benzene-1,2-diamines with 1,2-dicarbonyl compounds. Furthermore, the MIL-101-Cr-NH-RSO3H catalyst exhibits good stability, general applicability and excellent recycling performance.

An efficient protocol for the synthesis of quinoxaline derivatives at room temperature using molecular iodine as the catalyst

The use of molecular iodine as the catalyst for a one-pot synthesis of quinoxaline derivatives at room temperature is reported.

A sequential condensation route as a versatile platform for low cost and efficient hole transport materials in perovskite solar cells

In an effort to diminish the cost of perovskite solar cells (PSCs) with regard to hole transport materials (HTMs), we employed an easily attainable condensation route to synthesize a cheap and efficient HTM. Using a newly engineered small organic molecule

An efficient and green procedure for the synthesis of quinoxaline derivatives using 3,5-bis(Trifluoromethyl)phenylammonium triflate (bfpat) organocatalyst

The application of 3,5-bis(trifluoromethyl)phenylammonium triflate (BFPAT) as a conven-ient new organocatalyst for the synthesis of quinoxaline derivatives is described. In the presence of BFPAT, one-pot synthesis of a wide variety of quinoxaline derivati

Green Hydrothermal Synthesis of Fluorescent 2,3-Diarylquinoxalines and Large-Scale Computational Comparison to Existing Alternatives

Here, the hydrothermal synthesis (HTS) of 2,3-diarylquinoxalines from 1,2-diketones and o-phenylendiamines (o-PDAs) was achieved. The synthesis is simple, fast, and generates high yields, without requiring any organic solvents, strong acids or toxic catalysts. Reaction times down to 90 % in all cases). Moreover, it was shown that HTS has high compatibility: (i) hydrochlorides, a standard commercial form of amines, could be used directly as combined amine source and acidic catalyst, and (ii) Boc-diprotected o-PDA could be directly employed as substrate that underwent HT deprotection. A systematic large-scale computational comparison of all reported syntheses of the presented quinoxalines from the same starting compounds showed that this method is more environmentally friendly and less toxic than all existing methods and revealed generic synthetic routes for improving reaction yields. Finally, the application of the synthesized compounds as fluorescent dyes for cell staining was explored.

Organocatalytic combinatorial synthesis of quinazoline, quinoxaline and bis(indolyl)methanes

Aims and Objective: An efficient and practical procedure for the synthesis of heterocyclic compounds such as quinazolines, quinoxalines and bis(indolyl)methanes was developed using 3,5-bis(trifluoromethyl) phenyl ammonium hexafluorophosphate (BFPHP) as a novel organocatalyst. Materials and Methods: All of the obtained products are known compounds and identified by IR, 1HNMR, 13CNMR and melting points. Result: Various products were obtained in good to excellent yields under reaction conditions Conclusion: The BFPHP organocatalyst demonstrates a novel class of non-asymmetric organocatalysts, which has gained much attention in green chemistry.

Dowex 50W: Mild efficient reusable heterogeneous catalyst for synthesis of quinoxaline derivatives in aqueous medium

An efficient, simple and eco-friendly procedure is reported in presence of heterogeneous Dowex 50W catalyst in aqueous medium under refluxing condition to produce quinoxaline derivatives. Catalyst has participated in condensation reaction between 1,2-diamines and various aromatic 1,2-diketones smoothly with excellent yield of the products in short reaction times. Dowex 50W was used more than five times in this reaction separately and showed an excellent recyclability throughout the reaction.(figure presented).

Synthesis of a polymer-capped palladium nanoparticles and its application as a reusable catalyst in oxidative coupling reaction of α-hydroxyketones and 1,2-diamines for preparation of pyrazines and quinoxalines

A novel method for the synthesis of pyrazines and quinoxalines has been developed using α-hydroxyketones and 1,2-diamines in the presence of cross-linked poly(4-vinylpyridine)-stabilized Pd(0) nanoparticles, [P4-VP]-PdNPs. The catalyst was easily prepared and characterized using various techniques such as FT-IR and UV–Vis spectroscopy, AAS, TEM, FESEM, EDX analysis and XRD. The results confirm a good dispersion of palladium nanoparticles on the polymer support. The catalyst displayed good catalytic activity when applied to the synthesis of quinoxalines via condensation of α-hydroxyketones with 1,2-diamines. A few pyrazine derivatives and various quinoxalines are prepared via coupling reaction of α-hydroxyketones and 1,2-diamines in high–excellent yields (81–99%) with short reaction times. The quinoxalines products were characterized by FT-IR, 1H and 13C NMR spectroscopy, and the physical properties were compared to the literature values of known compounds. The advantages of the present method over conventional classical methods are rapid and very simple work-up, and the catalyst is reusable many times without a significant loss in its activity.

Ball-milling synthesized hydrotalcite supported Cu-Mn mixed oxide under solvent-free conditions: An active catalyst for aerobic oxidative synthesis of 2-acylbenzothiazoles and quinoxalines

A rapid solvent-free ball-milling method was developed to prepare a hydrophobic hydrotalcite supported Cu-Mn mixed oxide catalyst (Cu-Mn/HT). The mechanochemically prepared catalyst exhibited high catalytic activity and recyclability towards the aerobic synthesis of 2-acylbenzothiazoles and quinoxalines in green medium ethanol compared with the ones synthesized via grinding and wet-impregnation. Moreover, control experiments showed that the catalyst was successfully used in green oxidative esterification and coupling as well. Cu-Mn/HT was characterized by BET, ICP, XRD, XPS, SEM and TEM, which indicated that more surface oxygen vacancies and formed CuMn2O4 species on HT might contribute to the catalytic activity.

Ionic liquid functionalized cellulose as an efficient heterogeneous catalyst for the facile and green synthesis of benzoxazine, pyrazine and quinoxaline derivatives in aqueous media

Immobilization of acidic ionic liquid, 1-methyl-3-(3-trimethoxysilylpropyl) imidazolium hydrogen sulfate on cellulose (Cell-[pmim]HSO4) as an efficient heterogenous catalyst for the simple and environmentally benign synthesis of benzoxazine, pyrazine and quinoxaline derivatives in aqueous media at room temperature is described. The catalyst was characterized by FTIR spectroscopy and X-ray diffraction pattern. This method provides several advantages such as mild reaction conditions, environmentally friendly catalyst, good to excellent yields and simple work-up procedure.