33673-74-4

Usage

Uses

Used in Chemical Synthesis:
2,3-Dibromo-2-methylpropionic acid is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure with bromine atoms makes it a valuable building block in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3-dibromo-2-methylpropionic acid is used as a key intermediate in the synthesis of drugs. Its reactivity and bromine content allow for the creation of new drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
2,3-Dibromo-2-methylpropionic acid is used as a precursor in the development of agrochemicals, such as pesticides and herbicides. Its chemical properties enable the production of effective compounds for crop protection and management.
Used in Research and Development:
In the field of research and development, 2,3-dibromo-2-methylpropionic acid is utilized as a model compound for studying the reactivity and properties of bromoalkanes. This helps in understanding the behavior of similar compounds and their potential applications in various industries.

InChI:InChI=1S/C4H6Br2O2/c1-4(6,2-5)3(7)8/h2H2,1H3,(H,7,8)

Upstream product

• 79-41-4 poly(methacrylic acid) 
• 107790-73-8 2-methyl-3-(trimethylgermyl)propanoic acid 
• 75-15-0 carbon disulfide 
• 7726-95-6 bromine 
• 107790-83-0 2-methyl-3-(bromodimethylgermyl)propanoic acid 

Downstream Products

• 557-93-7 2-bromoprop-1-ene 
• 89123-63-7 3-bromo-2-methyl-2-propenoic acid 
• 10035-10-6 hydrogen bromide 
• 124-38-9 carbon dioxide 
• 67-64-1 acetone 

Relevant academic research and scientific papers

Enantioselective total syntheses of omuralide, 7-epi-omuralide, and (+)-lactacystin

(Chemical Equation Presented) An alkylidene carbene 1,5-CH insertion has been used as a key step in an enantioselective total syntheses of omuralide, its C7-epimer, and (+)-lactacystin. An additional noteworthy feature of the synthesis is the use of a nov

Synthesis and 15N- and 17O-NMR spectra of 5-methyl(15N2)[O2,O4-17O2]uridine (=(15N2)[O2,O4-17O2]ribosylthymine)

The 5-methyl(15N2)[O2,O4-17O2]uridine (=(15N2)[O2,O4-17O2]ribosylthymine; 15) was synthesized and analyzed by 15N- and 17O-NMR spectroscopy. (15N2)Urea was condensed with 2,3-dibromo-2-methylpropanoyl chloride (3) and cyclized to form (15N2)thymine (5). After glycosidation, the 17O isotopes were introduced in two separate steps: hydrolytic ring opening of 2,5'-anhydro derivative 9 and hydrolysis of 3-nitro-1H-1,2,4-triazole derivative 12 with labelled water in the presence of a strong base. The 15N- and 17O-NMR spectra of 15 in phosphate-buffered water serve as references for heteronuclear NMR spectra of labelled RNA fragments.

Synthesis and properties of germa-γ-lactones

Trialkylgermylpropanoic acids treated with 1 mole of bromine afford the monobromopropanoic acids, which are converted into the corresponding germa-γ-lactones in good yields by hydrolysis.The physical, chemical, and biological properties of these compounds are described.

The Synthesis and Molecular Structure of Tetra(isopropyl)silane

Tetra(isopropyl)silane has been prepared using literature methods, with the individual steps improved by changes in some of the experimental conditions.The key reagent 2-lithiopropene, which can now be obtained in good yields from 1-methacrylic acid via 1,2-dibromo-1-methylpropionic acid and 2-bromopropene by treatment of the latter with ultrasound-activated lithium metal, was shown to contain mono- and dilithiopropyne.The reaction with chlorotrimethylsilane led to the corresponding silylated derivatives, while with silicon tetrachloride tetra(isopropenyl)silane was obtained, which after purification is easily converted into the title compound by catalytic hydrogenation. - The gas phase molecular structure of 4Si has been determined by electron diffraction.The parameters could be successfully refined for a model of S4 symmetry.Bond distances Si-C, C-C, and C-H as well as bond angles Si-C-C and C-C-H show the steric compression of the four isopropyl substituents.Steric strain is minimized by twists of the methyl groups and the isopropyl groups away from the fully staggered conformations, but also by an increase of two of the C-Si-C angles as compared to the remaining four, which are decreased relative to the tetrahedral standard.The structure differs strongly (mainly in the twist angles) from that of the isoelectronic tetra(isopropyl)phosphonium cation in 4P(1+)(1-), but is very similar to those of tetra(cyclohexyl)silane and of tri(isopropyl)phosphonium isopropylide, where the pyramidal configuration of the ylidic carbon atoms leads to a pseudo homoleptic array of the substituents at phosphorus. - Key Words: Conformational analysis / Electron diffraction / Organosilanes / Silane, tetra(isopropyl)-

Convenient Syntheses of Cyclic Carboxamides from α,β,γ,δ and ε-halocarboxamides under Phase Transfer Conditions

Piperazine-2,5-diones (2) were prepared by N-alkylation between two molecules of α-halocarboxamides (1) in the presence of a phase transfer catalyst in yields of 64-88percent. β,γ,δ and ε-Lactams (6,9 and 13) were similarly synthesized by intramolecular N-alkylation of the corresponding halocarboxamides (5, 8 and 12) under phase transfer conditions in 53-99percent yields.Keywords--piperazine-2,5-dione; β-lactam; γ, δ, and ε lactams; bis-β-lactam; phase transfer catalyst; intramolecular N-alkylation