33697-33-5

Upstream product

• 5843-26-5 tetramethylphosphorodiamidous acid 
• 13880-55-2 N,N,N',N'-tetramethyl-C-phenylmethanediamine 
• 100-52-7 benzaldehyde 
• 1608-26-0 Hexamethylphosphorous triamide 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 2083-91-2 N,N-Dimethyltrimethylsilylamine 
• 124-40-3 dimethyl amine 

Downstream Products

• 40804-81-7 2-(benzo[d][1,3]dioxol-5-yl)-1-phenylethan-1-one 
• 134542-40-8 ((E)-2-Benzo[1,3]dioxol-5-yl-1-phenyl-vinyl)-dimethyl-amine 
• 451-40-1 phenyl benzyl ketone 
• 56437-43-5 (E)-1.2-Diphenyl-1-N_.N-dimethylaminoethen 
• 27356-33-8 2-(2-methoxyphenyl)-1-phenylethan-1-one 
• 134542-39-5 [(E)-2-(2-Methoxy-phenyl)-1-phenyl-vinyl]-dimethyl-amine 

Relevant academic research and scientific papers

Preparation of 1-substituted-5-[(2-oxo-2-phenyl)ethyl]imidazoles

New high yield preparation methods were developed for the pharmaceutically interesting compounds, 1-benzyl-, 1-methyl-, and 1H-5-[(2- oxo-2-phenyl)ethyl]imidazoles 1a-c, respectively. The title compounds were synthesized by four different methods using various starting materials. Two of the methods involved transformation reactions of the key intermediates, 1- substituted-5-[(2-nitro-2-phenyl)ethenyl]imidazoles 2a-c and 1-substituted-5- [(2-nitro-2-phenyl)ethyl]imidazoles 3a-c, while the other two utilized the oxidation of 1-substituted-5-[(2-hydroxy-2-phenyl)ethyl]imidazoles 4a-c, with chromic oxide, and the umpolung reaction of benzaldehyde followed by a condensation reaction of the umpolung intermediate with imidazolecarboxaldehydes 6a-c.

Aminosilylation of aldehydes mediated by lithium perchlorate: Novel method for synthesis of α-silylamines

α-Silylated N,N-dialkylamines 7a-k were easily synthesized in good to excellent yields from aldehydes 1, (trimethylsilyl)dialkylamines 2, and phenyldimethylsilyllithium 4, diphenylmethylsilyllithium 5, or triphenylsilyllithium 6, in concentrated ethereal

The reaction of arylaldehydes with hexamethylphosphorous triamide and the use of the resulting products for the synthesis of enamines and deoxybenzoins

The reaction between the arylaldehydes 1a,b and hexamethylphosphorous triamide 2 leads to the [aryl(dimethylamino)methyl]phosphonic bis(dimethylamides) 3a,b. These can be easily deprotonated by butyllithium in 1,2-dimethoxyethane and condensed with arylaldehydes to afford enamines 4a-f or deoxybenzoins 5a-f in fair to good yield.