3374-22-9

Basic information

• Product Name: 2-Amino-3-mercaptopropionic acid
• Synonyms: (RS)-2-Amino-3-mercapto-propansαure;Cysteine, DL-;DL-2-amino-3-mercaptopropanoicacid;DL-2-amino-3-mercaptopropionicacid;dl-cysteina;L-HSCH2CH(NH2)COOH;(+/-)-2-AMINO-3-MERCAPTOPROPIONIC ACID;2-AMINO-3-MERCAPTO-PROPIONIC ACID
• CAS NO: 3374-22-9
• Molecular Formula: C₃H₇NO₂S
• Molecular Weight: 121.16
• EINECS: 222-160-2
• Product Categories: Pharmaceutical Intermediates;Amino Acids
• Mol File: 3374-22-9.mol
• Article Data: 129

Chemical Properties

• Melting Point: 225 °C (dec.)(lit.)
• Boiling Point: 293.883 °C at 760 mmHg
• Flash Point: 131.536 °C
• Appearance: White to off-white/Powder
• Density: 1.197 (estimate)
• Vapor Pressure: 0.000411mmHg at 25°C
• Refractive Index: 1.5130 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Aqueous Acid (Sparingly), DMSO (Sightly), Water (Slightly)
• PKA: 2.07±0.10(Predicted)
• Water Solubility: Soluble in water (partly), 1 N HCl (25 mg/ml), ethanol, and acetic acid. Insoluble in acetone.
• Stability: Stable. Incompatible with strong oxidizing agents,
• BRN: 1721406
• CAS DataBase Reference: 2-Amino-3-mercaptopropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-mercaptopropionic acid(3374-22-9)
• EPA Substance Registry System: 2-Amino-3-mercaptopropionic acid(3374-22-9)

Safety Data

• Hazard Codes: Xn,Xi,C
• Statements: 20/21/22-36/37/38-22-35
• Safety Statements: 26-36-37/39-45-36/37/39
• RIDADR: UN 2923 6.1(8) / PGIII
• WGK Germany: 3
• RTECS: HA1595000
• F: 8-10-23
• Hazardous Substances Data: 3374-22-9(Hazardous Substances Data)

Usage

Chemical Properties

white solid

Uses

Different sources of media describe the Uses of 3374-22-9 differently. You can refer to the following data:
1. DL-Cysteine is a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Cysteine is commonly used as a precursor in the food and pharmaceutical industries. Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours.
2. DL-Cysteine is a NMDA agonist at quisqualate receptors at high concentration.

Definition

ChEBI: A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.

Biochem/physiol Actions

NMDA agonist that is an agonist at quisqualate receptors at high concentration.

InChI:InChI=1/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1

Upstream product

• 56-89-3 cysteine disulfide 
• 56-89-3 L-cystine 
• 143-33-9 sodium cyanide 
• 19538-81-9 N,S-diacetyl-cysteine 
• 91641-78-0 N-benzoyl-cysteine ethyl ester 
• 5680-65-9 2-amino-3-(benzylthio)propionic acid 
• 52-90-4 L-Cysteine 
• 7732-18-5 water 
• 10034-85-2 hydrogen iodide 
• 922-56-5 meso-lanthionine 
• 600-05-5 2,3-dibromopropionic acid 
• 498-59-9 S,S'-methylenebis(cysteine) 
• 7664-93-9 sulfuric acid 
• 7218-04-4 N-Acetylcysteine 

Downstream Products

• 89299-66-1 (RS)-2-amino-3-<(2-chloroethyl)sulfanyl>propanoic acid hydrochloride 
• 2139-90-4 2-amino-3-(ethylthio)propionic acid 
• 109819-52-5 N,S-bis-[(2,4,5-trichloro-phenoxy)-acetyl]-cysteine 
• 75-07-0 acetaldehyde 
• 921-01-7 D-cysteine 
• 56-89-3 cysteine disulfide 
• 6020-39-9 L-cystine 
• 923-32-0 DL-cystine 
• 56-89-3 L-cystine 
• 107-36-8 2-hydroxyethanesulfonic acid 
• 5680-65-9 2-amino-3-(benzylthio)propionic acid 
• 52386-79-5 S-(4-chloro-benzyl)-cysteine 
• 16708-09-1 2-methyl-thiazolidine-2,4-dicarboxylic acid 
• 49621-03-6 S-propenyl-L-cysteine 

Relevant articles and documents

Synthesis method of DL-cysteine

The invention discloses a synthetic method of DLcysteine. The method comprises the following steps: by using acrylonitrile as a raw material, chlorinating to generate 2, 3dichloropropionitrile, hydrolyzing to generate corresponding acid, reacting the acid with thiourea to cyclize to generate 2-aminothiazoline-4-carboxylic acid, adding alkali sulfide to generate 2-mercaptothiazoline-4-carboxylic acid, and hydrolyzing to generate cysteine. The synthesis method provided by the invention has the advantages of short synthesis steps, mild preparation conditions, sufficient and cheap raw material sources and higher product yield.

Cysteine Chemistry in Connection with Abiogenesis

Theoretical and experimental work has been conducted about possible prebiotic syntheses of cysteine. Activated derivatives of this amino acid can oligomerize and polymerize to afford various poly-thiazolines and cysteine-rich chains.

T Cells with Increased Immunosuppression Resistance

This invention relates to the treatment of cancer in an individual by administration of a population of modified T cells that express a recombinant cAMP phosphodiesterase (PDE) or a fragment thereof and an antigen receptor which binds specifically to cancer cells in the individual. Populations of modified T cells and methods of producing populations of modified T cells are provided, along with pharmaceutical compositions and methods of treatment