54075-25-1

Usage

Uses

Used in Personal Care Products:
Triclosan is used as an antimicrobial agent in personal care products for its ability to effectively kill a wide range of bacteria and fungi, contributing to improved hygiene and reducing the risk of infections.
Used in Household Products:
In addition to personal care products, triclosan is also used in household products to maintain cleanliness and prevent the growth of harmful microorganisms, ensuring a safer living environment.
However, it is important to note that due to concerns about triclosan's potential negative effects on human health and the environment, there is ongoing research and debate about its safety and regulation. Some studies have suggested that triclosan may disrupt hormones, contribute to antibiotic resistance, and have harmful effects on aquatic organisms when it enters water systems. As a result, certain countries have imposed restrictions on its use, and consumers are increasingly seeking alternative products that do not contain triclosan.

Upstream product

• 75-62-7 Bromotrichloromethane 
• 555-16-8 4-nitrobenzaldehdye 
• 650-51-1 sodium trichloroacetate 
• 619-73-8 4-nitrobenzyl chloride 
• 67-66-3 chloroform 
• 100-52-7 benzaldehyde 
• 76-03-9 trichloroacetic acid 
• 2000-43-3 2,2,2-trichloro-1-phenylethanol 

Downstream Products

• 117389-29-4 2-Amino-3-cyano-5-(4-nitro-phenyl)-4-oxo-cyclopent-2-enecarboxylic acid ethyl ester 
• 4714-32-3 1-nitro-4-(1,2,2,2-tetrachloro-ethyl)-benzene 
• 555-16-8 4-nitrobenzaldehdye 
• 104-03-0 4-nitrobenzeneacetic acid 
• 16208-23-4 2,2‐dichloro‐1‐(4‐nitrophenyl)ethan‐1‐one 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 34006-49-0 2-chloro-1-(4-nitrophenyl)ethanone 
• 10098-39-2 2-hydroxy-2-(4-nitrophenyl)acetic acid 
• 5281-22-1 1-(2,2-dichlorovinyl)-4-nitrobenzene 
• 1620143-51-2 ethyl [2,2,2-trichloro-1-(4-nitrophenyl)ethyl]carbonate 

Relevant academic research and scientific papers

The Decomposition of Trihalogenoacetic Acids in Dimethyl Sulphoxide: a Mild Route from Carbonyl Compounds to Trihalogenomethylethanols and Trihalogenomethyl Ketones

Solutions of trichloro- and tribromo-acetic acid in dimethyl sulphoxide in the presence of carbonyl compounds react at room temperature to give isolable products corresponding to the addition of H-CX3 across the carbonyl double bond.

PESTICIDAL COMPOUNDS AND METHODS OF USE

Described herein are compounds, pesticidally acceptable salts thereof, and compositions thereof that are useful, for example, for pest management and for controlling pests. In certain embodiments provided are enantioenriched and/or enantiopure compounds and pesticidally acceptable salts thereof, and methods of making same. Methods of controlling pests with the compounds of the disclosure are also provided.

A novel β-(oxy)alkyl radical during copper(I)-mediated stereoselective synthesis of (Z)-ene-1,4-diones in a reaction of 2,2,2-trichloro-1-phenylethanone

A novel β-(oxy)alkyl radical derived from trichloro methyl compound containing neither a suitably located C-C multiple bond nor a leaving group or a H-atom at the β-position of the radical in a reaction of 2,2,2-trichloro-1-phenyl-ethanone with 2 mol equiv each of CuCl and bpy in refluxing DCE under a N2 atm underwent intramolecular heterolysis (just like formation of intact radical cation-anion pair) during stereoselective radical dimerization to Z-ene-1,4-dione along with small amount of reductive dechlorination product. The stereochemistry was established by X-ray diffraction spectroscopy of various solid crystalline products.

One-Carbon Homologation of Primary Alcohols and the Reductive Homologation of Aldehydes Involving a Jocic-Type Reaction

(Trichloromethyl)carbinols, which are formed in one operation from either alcohols or aldehydes, can be converted into primary alcohols in a Jocic-type reaction involving LiBH4. The net result is a convenient two-step, one-carbon homologation of primary alcohols or a reductive one-carbon homologation of aldehydes featuring a broad substrate scope. The method is step-economical, and it nicely complements established one-carbon homologation strategies. (Trichloromethyl)carbinols, which are formed in one operation from either alcohols or aldehydes, can be converted into primary alcohols in a Jocic-type reaction involving LiBH4. The net result is a convenient two-step, one-carbon homologation of primary alcohols or a reductive one-carbon homologation of aldehydes featuring a broad substrate scope.

Decarboxylative trichloromethylation of aromatic aldehydes and its applications in continuous flow

Two new protocols for the efficient synthesis of 2,2,2- trichloromethylcarbinols, starting from aromatic aldehydes, have been developed. A combination of sodium trichloroacetate in the presence of malonic acid proved efficient for the transformation of el

β-(Carbonatoxy)alkyl radicals: A new subset of β-(ester)alkyl radical fragmentation during copper(I)-mediated synthesis of 1,1-dichloro-1-alkenes

A new subset of β-(ester)alkyl radicals is presented. It is the first study on the chemistry of β-(alkoxycarbonyloxy)alkyl radicals that fill the gap in the spectrum of the migrating groups in β-(ester)alkyl radical reactions. The change from less nucleofugal (acetate) group to the more nucleofugal (carbonate) group in the spectrum of the migrating group changed the reaction path from rearrangement to fragmentation. This approach has been used for the synthesis of 1,1-dichloroalkenes in high yields. The formation of dichloroalkenes was accounted by the involvement of alkene radical cation and carbonate anion pair (a CIP) as a result of heterolysis of the CO bond of the carbonate at the β-position of the β-(alkoxycarbonyloxy)alkyl radical. The alkene radical cation was trapped by nucleophilic reaction with MeOH to form methyl ester.

One-pot synthesis of trichloromethyl carbinols from primary alcohols

Versatile trichloromethyl carbinols can be prepared in one pot from primary alcohols by treatment with Dess-Martin periodinane (DMP) in CHCl3 followed by introduction of commercially available 1,5,7-triazabicyclo[4.4.0] dec-5-ene (TBD). A modification of the method was used to convert chiral primary alcohol (R)-(-)-2,2-dimethyl-1,3-dioxolane-4-methanol to the corresponding trichloromethyl carbinol with complete stereochemical fidelity, despite the reactant proceeding through a base-sensitive aldehyde intermediate.

General and practical conversion of aldehydes to homologated carboxylic acids

(Chemical Equation Presented) The reaction of aldehydes with trichloromethide followed by sodium borohydride or sodium phenylseleno(triethyl) borate under basic conditions affords homologated carboxylic acids in high yields. This operationally simple procedure provides a practical, efficient alternative to other homologation protocols. The approach is compatible with sensitive aldehydes including enals and enolizable aldehydes. It also offers convenient access to α-monodeuterated carboxylic acids.

Copper(I)-promoted synthesis of chloromethyl ketones from trichloromethyl carbinols

(Chemical Equation Presented) Reaction of several trichloromethyl carbinols with 2 equiv of CuCl/bpy in refluxing DCE for 3 h afforded chloromethyl ketones in excellent yield by 1,2-H shift in the copper-chlorocarbenoid intermediate.

Decomposition of sodium trichloroacetate in the presence of quaternary ammonium under microwave irradiation: A convenient one-pot synthesis of α-hydroxy acids in water

A good yielding phase-transfer-catalyzed procedure for one-pot preparation of α-hydroxy acids from carbonyl compounds and sodium trichloroacetate by in situ addition and hydrolysis under microwave irradiation is described. Decomposition of sodium trichloroacetate is strongly accelerated by the presence of quaternary ammonium. The reaction can be conducted in water. Copyright Taylor & Francis Group, LLC.