34102-86-8

Upstream product

• 5465-37-2 (E)-1,4-bis(4-chlorophenyl)but-2-ene-1,4-dione 
• 64-17-5 ethanol 
• 7803-57-8 hydrazine hydrate 
• 64-19-7 acetic acid 
• 27297-60-5 (Z)-1,4-bis(4-chlorophenyl)but-2-ene-1,4-dione 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 4996-21-8 1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone 
• 99-91-2 para-chloroacetophenone 
• 1289596-45-7 1,4-bis(4-chlorophenyl)-2-hydroxybutane-1,4-dione 
• 1679-18-1 4-Chlorophenylboronic acid 
• 20698-04-8 3,6-diiodopyridazine 
• 141-30-0 3,6-dichlorpyridazine 
• 23080-23-1 1,5-bis(4-chlorophenyl)-3-thiapentane-1,5-dione 
• 128256-29-1 C₁₄H₁₂BrClN₂O₂S 

Relevant academic research and scientific papers

Novel tandem reactions of 2,2′-sulfonylbis(1,3-diarylprop-2-en-1-ones) with hydrazine: Formation of 3,6-diarylpyridazines and 3,5-diarylpyrazoles

The 2,2′-sulfonylbis(1,3-diarylprop-2-en-1-ones) undergo tandem reactions with hydrazine affording 3,6-diarylpyridazines and 3,5-diarylpyrazoles unexpectedly, the latter predominating.

A green and practical one-pot two-step strategy for the synthesis of symmetric 3,6-diarylpyridazines

A simple, mild, and efficient synthesis of symmetric 3,6-diarylpyridazine derivatives using a green catalytic one-pot two-step reaction of aryl methyl ketones, arylglyoxal monohydrates, and hydrazine hydrate was developed. Environmentally benign nature, high atom-economy, no harmful byproduct, easy workup procedure, no column chromatography steps, and moderate to excellent yields of the products are the salient features of this new multicomponent-based methodology.

Efficient Suzuki-Miyaura mono-arylation of symmetrical diiodo(hetero)arenes

A reliable protocol for converting 1,4-diiodo-2,3,5,6-tetrafluorobenzene into 1-(hetero)aryl-4-iodo-2,3,5,6-tetrafluorobenzene derivatives has been lacking in the literature. We have identified optimal conditions to achieve this conversion in good yields and have minimized formation of the bis-coupling product. The newly identified protocol involving the use of a syringe pump has been extended to other symmetrical diiodo(hetero)arenes.

HETERO-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING THE SAME

The present invention relates to a heterocyclic compound represented by chemical formula 1, and an organic light emitting device comprising the same. In the organic light emitting device, efficiency can be improved, driving voltage is low, and/or lifespan characteristics can be improved.COPYRIGHT KIPO 2017

Highly selective mono-substitution in Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine with organozinc compounds

Pd-catalyzed cross-coupling reactions of 3,6-dichloropyridazine (1) with benzyl, aryl, and alkyl organozinc compounds led to selective mono-substitution of one of the chlorine atoms. The subsequent cross-coupling of the resulting monochlorides with RZnCl afforded unsymmetrical 3,6-carbon-disubstituted pyridazines.

Solid phase synthesis of pyridazine derivatives using polymer-bound sodium benzenesulfinate

A new solid phase synthesis of 3,6-disubstituted pyridazine derivatives, resulting from the reaction of polymer-bound sodium benzenesulfinate with α-bromoketone substrates followed by condensation with hydrazine, is described. Mild basic conditions for the condensation reaction simultaneously release the desired product from the solid support. The crystal structure of 3,6-bis(p-chlorophenyl)pyridazine is reported.

Degradational cyclization of α-[2-phenyl-2- (phenylsulfonylhydrazono)ethyl]phenacylidenetriphenylphosphoranes to 3,6- diphenylpyridazines and 5-benzoyl-3-phenylpyrazoles

α-[2-Phenyl-2- (phenylsulfonylhydrazono)ethyl]phenacylidenetriphenylphosphoranes were obtained (60-71%) by the reaction between phenylsulfonylhydrazones of phenacyl bromides and phenacylidenetriphenylphosphoranes. Thermolysis of the phosphoranes gave 3,6-diphenylpyridazines (43-66%) and 5-benzoyl-3- phenylpyrazoles (13-27%), together with triphenylphosphine oxide and S-phenyl benzenethiosulfonate, a disproportionation product from benzenesulfinic acid. The structure of the intermediate α-substituted phenacylidenetriphenylphosphorane was confirmed by an X-Ray diffraction method.

Preparation of 3,6-Disubstituted Pyridazines from 3-Thiapentane-1,5-diones via 2,7-Dihydro-1,4,5-thiadiazepines

A series of 3-thiapentane-1,5-diones condense with hydrazine in the presence of a catalytic amount of p-toluenesulfonic acid in refluxing ethanol to give 2,7-dihydro-1,4,5-thiadiazepines in excellent yields.Thermal decomposition of the latter compounds in

A CONVENIENT SYNTHESIS OF 3,6-DIARYLPYRIDAZINES

Cathodic reductions of phenacylbromides semicarbazones lead to 1,4-diaryl-1,4-butanedione disemicarbazones which give the corresponding 3,6-diarylpyridazines directly by heating.