34405-42-0Relevant articles and documents
Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof
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Paragraph 0198; 0200, (2017/10/10)
Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.
Electrochemical Reduction of Tertiary Nitroalkanes to Amines
Ohmori, Hidenobu,Furusako, Shoji,Kashu, Mieko,Ueda, Chihiro,Masui, Masaichiro
, p. 3345 - 3353 (2007/10/02)
Electrochemical reduction of tertiary nitroalkanes, 2-substituted-1,1-dimethyl-1-nitroethanes (1), was investigated in aqueous buffer solutions.In polarography, 1 with a phenyl group and/or a hydroxyl group at the 2-position showed an ill-defined wave in the weakly acidic and neutral pH region at relatively high negative potentials, in addition to a well-defined wave arising from the reduction of 1 to the corresponding hydroxylamine (2).Controlled potential electrolysis of 1 at the potential of the former wave gave the 1,1-dimethylethylamines (3) as well as the hydroxylamines 2.The amines 3 are formed exclusively from 2, probably via the O-protonated form.It is suggested that a phenyl group at the 2-position facilitates the reduction of 2 to 3 by enhancing the adsorption of 2 at the mercury cathode and that a hydroxyl group, while it interferes with the adsorption, assists the reduction by intramolecular hydrogen-bonding to stabilize the O-protonated form of 2.Keywords - tertiary nitroalkane; alkylhydroxylamine; electrochemical reduction; polarography; controlled potential electrolysis.
Improved Nitroaldol Reactions and Reductive Routes to Vicinal Aminoalcohols
Colvin, Ernest W.,Beck, Albert K.,Seebach, Dieter
, p. 2264 - 2271 (2007/10/02)
Regioselective and flexible procedures are described for the preparation of a variety of protected vicinal nitroalcohols 1, 3, and 5 (see Scheme 5), as is an efficient method for their reduction to the corresponding vicinal aminoalcohols 2, 4 and 6.