34425-87-1

Basic information

• Product Name: 2-[(4-CHLOROBENZOYL)AMINO]BENZOIC ACID
• Synonyms: 2-{[(4-chlorophenyl)carbonyl]amino}benzoic acid
• CAS NO: 34425-87-1
• Molecular Formula: C₁₄H₁₀ClNO₃
• Molecular Weight: 275.69
• Mol File: 34425-87-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 204-205 °C
• Boiling Point: 380.6°Cat760mmHg
• Flash Point: 184°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 1.8E-06mmHg at 25°C
• Refractive Index: 1.677
• PKA: 3.38±0.36(Predicted)
• CAS DataBase Reference: 2-[(4-CHLOROBENZOYL)AMINO]BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-CHLOROBENZOYL)AMINO]BENZOIC ACID(34425-87-1)
• EPA Substance Registry System: 2-[(4-CHLOROBENZOYL)AMINO]BENZOIC ACID(34425-87-1)

Safety Data

• Hazardous Substances Data: 34425-87-1(Hazardous Substances Data)

Usage

Functional Groups

Chlorobenzoyl group: This group consists of a benzene ring with a chlorine atom attached directly to the benzene ring and connected to the rest of the molecule via a carbonyl group (C=O).
Amino group: This group consists of a nitrogen atom bonded to two hydrogen atoms and connected to the rest of the molecule via a carbonyl group.

Applications

Building block in pharmaceutical synthesis
Building block in agrochemical synthesis
Research reagent in organic chemistry and biochemistry studies

Potential Applications

Development of new drugs
Development of crop protection products

Chemical Properties

Due to its unique structure, 2-[(4-chlorobenzoyl)amino]benzoic acid exhibits specific chemical reactivity that makes it valuable in various synthetic pathways for pharmaceuticals and agrochemicals.

InChI:InChI=1/C14H10ClNO3/c15-10-7-5-9(6-8-10)13(17)16-12-4-2-1-3-11(12)14(18)19/h1-8H,(H,16,17)(H,18,19)

Upstream product

• 1211-35-4 2-(4-chlorophenyl)-1H-indole 
• 18600-52-7 2-(4-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 108-88-3 toluene 
• 118-92-3 anthranilic acid 
• 74-11-3 para-chlorobenzoic acid 
• 37619-18-4 methyl 2-(4-chlorobenzamido)benzoate 
• 122-01-0 4-chloro-benzoyl chloride 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 104830-73-1 4-chloro-N-(2-hydrazinocarbonyl-phenyl)benzamide 
• 1314603-07-0 4-amino-N-[2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl]benzenesulfonamide 
• 1314602-98-6 C₂₂H₁₇ClN₄O₄S 
• 18600-52-7 2-(4-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

A straightforward TBHP-mediated synthesis of 2-amidobenzoic acids from 2-arylindoles and their antimicrobial activity

A simple and highly efficient strategy has been developed for the synthesis of 2-amidobenzoic acids through the tert-butyl hydroperoxide (TBHP)-mediated oxygenation and sequential ring opening of 2-arylindoles in a one-pot fashion under metal-free aerobic conditions. The developed synthetic protocol is operationally simple, tolerates a wide range of functional groups, and is amenable to the gram-scale. Radical trapping experiments revealed that the reaction involves a radical pathway. The synthesized compounds (2a-s) were tested for in vitro antimicrobial activity. Among all screened compounds, 2d showed the maximum antibacterial activity against P. aerugunosa (ZOI = 17 mm, MIC = 32 μg mL-1) and compounds 2d and 2p showed the maximum (32 μg mL-1) antifungal activity against A. flavus and C. albicans.

Substituent effects on hydrogen bonding of aromatic amide-carboxylate

N-(p-benzoyl)-anthranilic acid (BAA) derivatives have been synthesized with different substituents (X: Br, Cl, OCH3, CH3), and their crystal structures have been analyzed in order to understand the variations in their molecular geome

Precursor-directed combinatorial biosynthesis of cinnamoyl, dihydrocinnamoyl, and benzoyl anthranilates in saccharomyces cerevisiae

Biological synthesis of pharmaceuticals and biochemicals offers an environmentally friendly alternative to conventional chemical synthesis. These alternative methods require the design of metabolic pathways and the identification of enzymes exhibiting ade