34859-82-0

Basic information

• Product Name: 4-NITRO-4'-T-BUTYL DIPHENYL ETHER
• Synonyms: 4-NITRO-4'-T-BUTYL DIPHENYL ETHER;4-Nitro-4'-tert-butyldiphenyl ether;Benzene, 1-(1,1-dimethylethyl)-4-(4-nitrophenoxy)-;1-tert-butyl-4-(4-nitrophenoxy)benzene
• CAS NO: 34859-82-0
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.31108
• Mol File: 34859-82-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 364.5 °C at 760 mmHg
• Flash Point: 138.3 °C
• Appearance: /
• Density: 1.137 g/cm³
• CAS DataBase Reference: 4-NITRO-4'-T-BUTYL DIPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-4'-T-BUTYL DIPHENYL ETHER(34859-82-0)
• EPA Substance Registry System: 4-NITRO-4'-T-BUTYL DIPHENYL ETHER(34859-82-0)

Safety Data

• Hazardous Substances Data: 34859-82-0(Hazardous Substances Data)

Usage

General Description

4-Nitro-4'-t-butyl diphenyl ether is a chemical compound with the molecular formula C16H15NO3. It is a nitro-substituted diphenyl ether derivative that is often used as a radical polymerization inhibitor. 4-NITRO-4'-T-BUTYL DIPHENYL ETHER is a yellow crystalline solid that is insoluble in water and stable under normal temperatures and pressures. It is commonly used as a stabilizer in plastics and rubbers, as well as in the production of other organic compounds. However, it is important to handle this chemical with care, as it is toxic and may cause skin and eye irritation, as well as respiratory issues if inhaled. Additionally, it may be harmful to aquatic organisms and should be disposed of properly to prevent environmental contamination.

Upstream product

• 98-54-4 para-tert-butylphenol 
• 100-00-5 4-chlorobenzonitrile 
• 59970-38-6 4-tert-butylphenyl mesylate 
• 350-46-9 4-Fluoronitrobenzene 
• 5787-50-8 sodium 4-tert-butylphenolate 
• 100-02-7 4-nitro-phenol 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 636-98-6 p-nitrobenzene iodide 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 142342-33-4 4,4'-di(tert-butyl)diphenyliodonium tosylate 
• 253185-03-4 tert-butylbenzene 
• 25237-79-0 (4-tert-butylphenoxy)trimethylsilane 
• 586-78-7 para-nitrophenyl bromide 
• 32848-23-0 para-nitrophenyl perfluorobutanesulfonate 

Downstream Products

• 56705-89-6 4-(4-(tert-butyl)phenoxy)aniline 
• 100-02-7 4-nitro-phenol 
• 98-54-4 para-tert-butylphenol 

Relevant articles and documents

Structural optimization and structure–activity relationship of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase

Human dihydroorotate dehydrogenase (hDHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising hDHODH inhibitors is in high demand. Based on the unique binding mode of our previous reported 4-thiazolidinone derivatives, via molecular docking method, three new series 4-thiazolidinone derivatives were designed and synthesized as hDHODH inhibitors. The preliminary structure–activity relationship was investigated. Compound 9 of biphenyl series and compound 37 of amide series displayed IC50 values of 1.32 μM and 1.45 μM, respectively. This research will provide valuable reference for the research of new structures of hDHODH inhibitors.

CsF/clinoptilolite: An efficient solid base in SNAr and copper-catalyzed Ullmann reactions

CsF/clinoptilolite was found to be an efficient solid base catalyst for both SNAr and Ullmann ether reactions. A general and efficient one-step procedure was developed for the synthesis of biaryl ethers via direct coupling of electron-deficient aryl halides to phenols using CsF/clinoptilolite. The protocol was also applied to electron-rich aryl halides by addition of a catalytic amount of copper oxide nanoparticles. Both SNAr and Ullmann reactions were rapid and provided good to excellent yields.

Palladium nanoparticles supported on natural nanozeolite clinoptilolite as a catalyst for ligand and copper-free C-C and C-O cross coupling reactions in aqueous medium

In this article, Pd0-nanoparticles supported on natural nanozeolite clinoptilolite (CP) were successfully synthesized, and the catalytic activity of the nanocatalyst was investigated in C-C and C-O coupling reactions, namely the Sonogashira and Ullmann condensation reactions in an aqueous medium. The nanocatalyst was characterized by various techniques such as powder-XRD, BET, SEM, TEM, HRTEM, TEM-EDS, ICP-OES and XPS. From an electron microscopy (SEM) study it can be inferred that the particles are mostly spherical or of ellipsoidal shape and have diameters ranging from 25 to 80 nm. A HRTEM study reveals that Pd0-nanoparticles supported on nanozeolite CP have an average diameter of ～10 nm. The supported palladium nanoparticles showed excellent catalytic activity in the synthesis of aryl alkynes and diaryl ethers in high yields. In addition, the nanocatalyst could be recycled and reused several times without significant loss of catalytic activity.