35154-55-3

Basic information

• Product Name: natsudaidain
• Synonyms: natsudaidain
• CAS NO: 35154-55-3
• Molecular Formula: C₂₁H₂₂O₉
• Molecular Weight: 418.39398
• Mol File: 35154-55-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 608.3°Cat760mmHg
• Flash Point: 212.3°C
• Appearance: /
• Density: 1.314g/cm³
• Vapor Pressure: 1.18E-15mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: natsudaidain(CAS DataBase Reference)
• NIST Chemistry Reference: natsudaidain(35154-55-3)
• EPA Substance Registry System: natsudaidain(35154-55-3)

Safety Data

• Hazardous Substances Data: 35154-55-3(Hazardous Substances Data)

Usage

General Description

Natsudaidain is a chemical compound found in the peels of the natsudaidai, a type of citrus fruit. It is a polymethoxylated flavone, a type of flavonoid with potential antioxidant and anti-inflammatory properties. Natsudaidain has been studied for its potential therapeutic effects, including the ability to reduce oxidative stress, inflammation, and age-related cognitive decline. It has also shown promise in protecting against cardiovascular diseases, cancer, and neurodegenerative disorders. Research on natsudaidain is ongoing, and further studies are needed to fully understand its potential health benefits and applications in medicine.

InChI:InChI=1/C21H22O9/c1-24-11-8-7-10(9-12(11)25-2)16-15(23)14(22)13-17(26-3)19(27-4)21(29-6)20(28-5)18(13)30-16/h7-9,23H,1-6H3

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Downstream Products

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Relevant articles and documents

Studies on the differentiation inducers of myeloid leukemic cells from Citrus species

An attempt was made to isolate differentiation inducers from Aurantii Nobilis Pericarpium and the fruit peel of Citrus reticulata Blanco (Rutaceae). Twenty-seven kinds of flavones, including five new flavones, were isolated after repeated chromatography from methanol extracts of these plants and their structures were established, from their physicochemical data, to be highly methoxylated flavones. Each compound, except for two flavone glucosides, showed the differentiation inducing activity toward mouse myeloid leukemia cells (M1), and the cells came to have phagocytic activity. Furthermore, differentiation inducing activity was tested using human acute promyelocytic leukemia cell line (HL-60).

Semisynthesis of polymethoxyflavonoids from naringin and hesperidin

Polymethoxyflavonoids (PMFs) possess important biological activities, notably as anticancer agents. Semisynthesis of a series of PMFs were performed by glycoside hydrolysis, dehydrogenation, bromination, aromatic nucleophilic substitution, O-methylation, dimethyldioxirane oxidation and regioselective demethylation, starting from abundant and inexpensive natural sources naringin and hesperidin. A new synthetic method for selective methylation using CuBr catalysed and microwave-assisted reaction was developed, and the dimethyl dioxirane oxidation of flavones to flavonols was much improved. The new semisynthetic route has the advantages of easy availability of starting materials, simple operation and good yields.

Regioselective hydroxylation of 2-hydroxychalcones by dimethyldioxirane towards polymethoxylated flavonoids

The flavone nucleus is part of a large number of natural products and medicinal compounds. In this presentation the novel regioselective hydroxylation of hydroxyarenes with DMD is described. The results showed further that flavonoids with 5-hydroxy group were selectively oxyfunctionalized at the para-position C8 carbon atom by DMD. Finally, according to this methodology, the naturally occurring isosinensetin, tangeretin, sinensetin, nobiletin, natsudaidain, gardenin B, 3,3′,4′,5,6,7,8- heptamethoxyflavone, quercetin and its derivatives were synthesized.