1176-88-1

Basic information

• Product Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one
• Synonyms: 4H-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-
• CAS NO: 1176-88-1
• Molecular Formula: C₂₁H₂₂O₉
• Molecular Weight: 418.394
• Mol File: 1176-88-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 631.7°C at 760 mmHg
• Flash Point: 221.4°C
• Density: 1.37g/cm³
• Vapor Pressure: 1.49E-16mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one(1176-88-1)
• EPA Substance Registry System: 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one(1176-88-1)

Safety Data

• Hazardous Substances Data: 1176-88-1(Hazardous Substances Data)

Usage

General Description

2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one is a chemical compound generally associated with the class of synthetic compounds known as flavonoids. Specifically, it can be classified under methoxyflavones because of the multiple methoxy (OCH3) groups present in its structure, and it also possesses a hydroxyl (-OH) group. The presence of these functional groups can potentially confer polarity, solubility, and reactivity properties to the compound. As such, it holds potential for being explored in several scientific fields such as medicine, chemistry, and pharmacology for its biochemical activities. The exact properties and applications of this chemical compound, however, would be dependent upon further rigorous experimental studies.

Upstream product

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Downstream Products

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Relevant articles and documents

CHEMISTRY OF TOXIC RANGE PLANTS. HIGHLY OXYGENATED FLAVONOL METHYL ETHERS FROM GUTIERREZIA MICROCEPHALA

Gutierrezia microcephala; Broomweed; Compositae; Astereae; flavonol; oxygenated kaempferol; quercetin and myricetin derivatives; 13C NMR.The perennial American desert shrub, Gutierrezia microcephala, contains 20 flavonol methyl ethers displaying nine different oxygenation patterns.These include 11 new flavonols: 5,7-dihydroxy-3,6,8,3',4',5'-hexamethoxyflavone, 5,7,4'-trihydroxy-3,6,8,3',5'-pentamethoxyflavone, 5,7,3'-trihydroxy-3,6,8,4',5'-pentamethoxyflavone, 5,7,2',4'-tetrahydroxy-3,6,8,5'-tetramethoxyflavone, 5,7,3',4'-tetrahydroxy-3,6,8-trimethoxyflavone, 5,7,8,3',4'-pentahydroxy-3,6-dimethoxyflavone, 3,5,7,3',4'-pentahydroxy-6,8-dimethoxyflavone, 5,7,4'-trihydroxy-3,6,8-trimethoxyflavone, 5,7,8,4'-tetrahydroxy-3,3'-dimethoxyflavone, 5,7,8,3',4'-pentahydroxy-3-methoxyflavone and 5,7,8,4'-tetrahydroxy-3-methoxyflavone.In addition, the following known flavonols were isolated: 5,7-dihydroxy-3,8,3',4',5'-pentamethoxyflavone, 5,7,4'-trihydroxy-3,8-dimethoxyflavone, 5,7,4'-trihydroxy-3,8,3'-trimethoxyflavone, 5,7,3',4'-tetrahydroxy-3,8-dimethoxyflavone, 5,7,4'-trihydroxy-3,6,3'-trimethoxyflavone, 5,7,3',4'-tetrahydroxy-3-methoxyflavone, 5,4'-dihydroxy-3,6,7,8,3'-pentamethoxyflavone, 5,7,4'-trihydroxy-3,6,8,3'-tetramethoxyflavone and 3,5,7,4'-tetrahydroxy-6,8,3'-trimethoxyflavone.

Semisynthesis of polymethoxyflavonoids from naringin and hesperidin

Polymethoxyflavonoids (PMFs) possess important biological activities, notably as anticancer agents. Semisynthesis of a series of PMFs were performed by glycoside hydrolysis, dehydrogenation, bromination, aromatic nucleophilic substitution, O-methylation, dimethyldioxirane oxidation and regioselective demethylation, starting from abundant and inexpensive natural sources naringin and hesperidin. A new synthetic method for selective methylation using CuBr catalysed and microwave-assisted reaction was developed, and the dimethyl dioxirane oxidation of flavones to flavonols was much improved. The new semisynthetic route has the advantages of easy availability of starting materials, simple operation and good yields.