3516-07-2

Upstream product

• 645-36-3 2,2-diethoxy-ethanamine 
• 108-95-2 phenol 
• 7647-01-0 hydrogenchloride 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 858011-57-1 4-(4,4'-dimethoxy-benzhydryl)-4,5-dihydro-benz[f][1,4]oxazocine-1,3,6-trione 
• 22483-09-6 2,2-dimethoxyethylamine 

Downstream Products

• 955118-82-8 acetic acid (2S,3R,4R,5R)-4-acetoxy-5-{6-[2,2-bis-(4-hydroxy-phenyl)-ethylamino]-2-chloro-purin-9-yl}-2-(3-ethyl-isoxazol-5-yl)-tetrahydro-furan-3-yl ester 
• 955972-47-1 C₃₄H₄₁ClN₆O₈ 

Relevant academic research and scientific papers

Enantioselective desymmetrization of bisphenol derivatives via Ir-catalyzed allylic dearomatization

Spirocyclic hexadienones with multiple stereogenic centers are frequently found in natural products but remain challenging targets to synthesize. Herein, we report the enantioselective desymmetrization of bisphenol derivatives via Ir-catalyzed allylic dearomatization reactions, affording spirocyclic hexadienone derivatives with up to three contiguous stereogenic centers in good yields (up to 90%) and excellent enantioselectivity (up to 99% ee). The high efficiency of this reaction is exemplified by the short reaction time (30 min), low catalyst loading (down to 0.2 mol %), and ability to perform the reaction on a gram-scale. The total syntheses of (+)-tatanan B and (+)-tatanan C were also realized using this Ir-catalyzed allylic dearomatization reaction as a key step.