35520-41-3

Usage

Uses

Used in Pharmaceutical Research:
3-(DIMETHYLAMINO)ACRYLONITRILE is used as a subject of study for [investigating vestibular toxicity] in [wild type (129S1) and CYP2E1-null mice]. The reason for this application is to understand the compound's potential effects on the vestibular system and its interaction with the CYP2E1 enzyme, which could have implications for the development of treatments or interventions related to balance and spatial orientation disorders.
Used in Toxicology Studies:
In the field of toxicology, 3-(DIMETHYLAMINO)ACRYLONITRILE is used as a test compound for [evaluating the role of CYP2E1-mediated metabolism] in [vestibular toxicity]. This application helps researchers to determine the compound's toxicity profile and its potential risks to human health, particularly in relation to the vestibular system.
Used in Drug Development:
3-(DIMETHYLAMINO)ACRYLONITRILE may also be used as a starting material or intermediate in [the synthesis of new pharmaceutical compounds] for [treating conditions related to the vestibular system]. The application reason is based on the compound's structural properties and its interaction with the CYP2E1 enzyme, which could potentially be leveraged to develop novel therapeutic agents.

InChI:InChI=1S/C5H8N2/c1-7(2)5-3-4-6/h3,5H,1-2H3/b5-3+

Upstream product

• 124-40-3 dimethyl amine 
• 764-42-1 1,2-Dicyanoethylene 
• 5762-56-1 tris(dimethylamino)methane 
• 107-13-1 acrylonitrile 
• 6926-39-2 N-Chlor-N',N',N',N'-tetramethyl-guanidin 
• 35520-40-2 cis-β-dimethylaminoacrylonitrile 
• 372-09-8 cyanoacetic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 1070-71-9 propiolonitrile 
• 28562-53-0 4-acetoxy azetidinone 
• 1608-26-0 Hexamethylphosphorous triamide 
• 123-75-1 pyrrolidine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 5815-07-6 ethoxy-bis-(dimethylamino)-methane 

Downstream Products

• 3346-63-2 2,6-diamino-3-nitro-pyridine 
• 149325-34-8 3-(N-carboethoxymethyl)aminoacrylonitrile 
• 33252-28-7 6-chloronicotinonitrile 
• 10365-94-3 1,3,5-tricyanobenzene 
• 74738-17-3 fenpiclonil 
• 16849-88-0 1-(dimethylamine)-2,2-dicyanoethylene 
• 149139-41-3 α-cyano-β-dimethylaminoacrolein 
• 709-04-6 1-phenyl-1H-pyrazole-4-carbonitrile 
• 934329-28-9 2-(4-bromophenyl)pyrazolo[1,5-a]pyrimidin-7-amine 

Relevant academic research and scientific papers

Formation of Enamines via Catalytic Dehydrogenation by Pincer-Iridium Complexes

Di-isopropylphosphino-substituted pincer-ligated iridium catalysts are found to be significantly more effective for the dehydrogenation of simple tertiary amines to give enamines than the previously reported di-t-butylphosphino-substituted species. It is

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

2-(arylimino-methyl)-3-dialkylaminoacrylonitriles, a process for their preparation and their use

2-(Arylimino-methyl)-3-dialkylaminoacrylonitriles can be obtained by reaction of β-anilino-acrylonitriles with ortho-formamides. They are suitable as starting substances for the preparation of 4-amino-5-iminiummethylene-2-pyrimidines or 4-amino-5-formyl-2

Process for the preparation of 2,5-disubstituted pyridines

2,5-Disubstituted pyridines of the formula STR1 can be prepared by reacting enamines of the formula STR2 with β-amino-acrylonitriles of the formula STR3 and treating the open-chain intermediate, which represents a R-R1 -5-amino-penta-2,4-dienonitrile, with protic acids or with ammonia.

A One Pot Synthesis of β-Cyanoenamines

Orthoesters, cyanoacetic acid and secondary amines react together, in a one step procedure, to produce β-cyanoenamines.

Method of preparing β-alkoxyacrlonitriles

A process for the preparation of a β-alkoxyacrylonitrile of the formula where R is hydrogen or an alkyl moiety, among others, by contacting a compound of the formula where Me is an alkali metal or alkaline earth metal and α is 1 or 2 respectively, an elevated temperature with a halogen compound of the formula where R' is among others a straight or branched alkyl or alkenyl moiety and Hal represents chlorine, bromine, or iodine. Also disclosed is a process for preparing a 3-amino-acrylonitrile of the formula STR1 where R5 and R6 represent, among others, hydrogen, alkyl or alkenyl by contacting a 3-alkoxyacrylonitrile or a metal salt of 3-hydroxyacrylonitrile with ammonia and/or amine. Also disclosed is a process for the preparation of such 3-aminoacrylonitrile by contacting a 3-alkoxyacrylonitrile of the formula STR2 where R' has the meaning given above and R7 has the same meaning as R stated above with an amine of the formula STR3 wherein R5 and R6 represent among others hydrogen, alkyl or alkenyl. The application further discloses a process for preparing a 3-amino-acrylonitrile of the formula STR4 where R5, R6 and R7 have the above meanings by contacting a compound of the formula EQU1 with an amine. The Application also discloses the preparation of two-cyanovinyl esters by reaction of a cyanovinyl compound of the formula EQU2 with an acid halide or an acid anhydride.

AMINOPHOSPHONIC ACID AND AMINOPHOSPHINIC ACID ANALOGUES OF ASPARTIC ACID

4-Oxoazetidin-2-ylphosphonates and phosphinates, obtained from Arbusov reactions of 4-acetoxyazetidin-2-one and 4α-acetoxy-3β-phthalimido-2-one with a variety of phosphites and phosphonites, were hydrolysed to β-phosphono- and β-phosphino β-alanine (phosphono- and phosphinoaspartic acid) derivatives.In model studies for their incorporation in peptides, conditions for the selective removal of protecting groups for carboxylic acids, phosphonic and phosphinic acids, and amines, in derived di- and tripeptides were investigated.Alanyl and alanyl alanyl peptide incorporation into bacteria was studied.