3572-34-7Relevant academic research and scientific papers
Studies on 2,3,N,N'-substituted 4,4'-diaminodiphenylsulfones as potential antimalarial agents
Saxena,Saxena,Raina,Chandra,Sen,Anand,Seydel,Wiese
, p. 1081 - 1084 (2007/10/02)
A series of new 4,4'-diaminodiphenylsulfones substituted at 2 and 3 position and also at primary amino group of the phenyl rings have been synthesised and evaluated for their antimalarial activity against Plasmodium berghei infection in mice. Some of these compounds were active and showed complete inhibition of parasitaemia which included 7a1-7a4, 7b3, 7b4 and 16a at 1 mg/kg i.p. for 4 days and 16a, at 0.3 mg/kg for 4 days. Some compounds tested for their synthetase inhibitory action in cell-free system isolated from P. berghei (7b1, 7b2 and 8b2) were found to be more active than diaminodiphenylsulphone. The difference in order of activity between these in vivo and in vitro tests may be due to differences in their pharmacokinetic properties.
Experimental and Theoretical Study of Electronic Substituent Effects in 4-Aminoaryl (4-Substituted Aryl) Sulphones
Benedetti, Pier G. De,Folli, Ugo,Iarossi, Dario,Frassineti, Chiara
, p. 1527 - 1532 (2007/10/02)
Substituent effects on the electronic structure of 23 biologically active 4-aminoaryl (4-substituted aryl) sulphones were investigated by means of 1H n.m.r., 13C n.m.r., and i.r. spectroscopy, as well as by semiempirical all-valence CNDO/2 calculations, w
