357399-11-2Relevant academic research and scientific papers
Deoxynucleic guanidine: Synthesis and incorporation of purine nucleosides into positively charged DNG oligonucleotides
Challa, Hemavathi,Bruice, Thomas C.
, p. 1475 - 1481 (2007/10/03)
The synthesis of purine nucleosides capable of making the guanidinium linkage is described for the first time starting from the corresponding 2′-deoxynucleosides. The positively charged mixed base DNG oligomer containing guanine was synthesized on solid-p
Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences
Reddy, Putta Mallikarjuna,Bruice, Thomas C.
, p. 1281 - 1285 (2007/10/03)
Positively charged DNG oligonucleotide mixed sequences containing A/T bases were prepared by solid-phase synthesis. Synthesis proceeds in 3′→5′ direction and involves coupling of 3′-Fmoc protected thiourea in the presence of HgCl2/TEA with the corresponding 5′-amine of the growing oligo chain. DNG binding characteristics with complementary DNA and with itself have been evaluated.
