36602-06-9

Upstream product

• 50-00-0 formaldehyd 
• 143-33-9 sodium cyanide 
• 122-39-4 diphenylamine 
• 590-17-0 cyanomethyl bromide 
• 7677-24-9 trimethylsilyl cyanide 
• 607-00-1 diphenylformamide 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 552-82-9 benzhydrylidene(methyl)amine 
• 107-14-2 chloroacetonitrile 
• 151-50-8 potassium cyanide 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 103331-67-5 1,2-bis-(2-diphenylaminomethyl-4,5-dihydro-imidazol-1-yl)-ethane 
• 1140-29-0 N-(2-aminoethyl)-N-phenylaniline 
• 725744-39-8 N-(4,5-dihydro-1H-2-imidazolylmethyl)-N,N-diphenylamine 
• 79726-44-6 1-(Diphenylamino)-2-hydroxy-2-phenylacrylnitril 
• 42164-54-5 N-(2-amino-1-phenylethyl)benzenamine 

Relevant academic research and scientific papers

Photo and electroluminescence of 2-anilino-5-phenylpenta-2,4-dienenitrile derivatives

Three derivatives of 2-anilino-5-phenylpenta-2,4-dienenitrile, i.e. 1-3, were assessed as the emitting materials in organic electroluminescent devices. A single hetero-junction device was fabricated using 2 (or 3) as the emitter, which was doped 3% by wei

Iron-catalyzed reductive strecker reaction

Strecker reaction is widely applied for the synthesis of amino acids from aldehydes, amines and cyanides. Herein, we report the FeI2-catalyzed reductive Strecker type reaction of formamides instead of aldehydes to produce amino acetonitriles. The challenging capture of carbinolamine intermediates by CN? was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodology is demonstrated by 1) one-pot construction of (13C labeled) complex molecules from CO2 via amino acetonitrile intermediates and 2) convenient production of homologated carboxylic acids from aldehydes.

Metal-Free Aerobic Oxidative Cyanation of Tertiary Amines: Azobis(isobutyronitrile) (AIBN) as a Sole Cyanide Source

An aerobic oxidative cyanation for the synthesis of α-aminonitriles was reported. The formation of C(sp3)-CN bonds was achieved under a metal-free condition by utilizing azobis(isobutyronitrile) as a sole organic cyanide source with the combination of pivalic acid and sodium acetate as additives.

N-(substituted-anilinoethyl)amides: Design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands

A novel series of melatonin receptor ligands, characterized by a N-(substituted-anilinoethyl)amido scaffold, along with preliminary structure-activity relationships (SARs), is presented. MT1 and MT2 receptor binding affinity and intr

NOVEL MELATONIN LIGANDS HAVING ANTIDEPRESSANT ACTIVITY AS WELL AS SLEEP INDUCING PROPERTIES

Novel melatonin ligands of Formula (I) or pharmaceutically acceptable salts thereof wherein: n is 1 or 2; m is 0, 1 or 2; p is 0, 1, 2, 3, 4, 5, 6, 7 or 8; v is 2 or 3; A is aryl or heteroaryl; Z is O, S or NR8;Y is selected from the group consisting of hydrogen, aryl, heteroaryl, CrC6 alkyl, C3-C6 cycloalkyl, and R is selected from the group consisting of hydrogen, hydroxyl, -OCF3, CF3, C1-C8 alkyl, C1C8 alkyloxy, C1C8 alkylthio, halogen and -Z-(CH2)P-A; R1 is selected from the group consisting of C1C4 alkyl, C3-C6 cycloalkyl, CF3, hydroxy-substituted C1C4 alkyl, hydroxy-substituted C3-C6 cycloalkyl, and NHR5, wherein R5 is C1C3 alkyl or C3-C6 cycloalkyl; R2 is selected from the group consisting of: hydrogen, C1C4 alkyl, C1C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R3 is selected from the group consisting of hydrogen, C1C4 alkyl, C1C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R and R3 may be connected together to form an -0-(CH2)v bridge representing with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring system; R4 is selected from the group consisting of hydrogen, C1C4 alkyl, C1C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; R6 is selected from the group consisting of hydrogen and C1C6 alkyl; R7 is selected from the group consisting of hydrogen, C1C4 alkyl, C1C4 alkyloxy, OCF3, CF3, hydroxyl, and halogen; and R8 is selected from the group consisting of hydrogen and C1C4 alkyl.

Alkylation of diphenylamines with chloroacetonitrile: A new entry to phentolamine analogues

The alkylation of diphenylamines with chloroacetonitrile followed by annulation with ethylenediamine gave 2-imidazoline analogues of phentolamine.

Agents for the treatment of overactive detrusor. IV. Synthesis and structure-activity relationships of cyclic analogues of terodiline

A series of pyrrolidine derivatives were synthesized and examined for inhibitory activity on detrusor contraction in vivo. Among those compounds, 5,5-dimethyl-2-(2,2-diphenylethyl)-3-isopropylidenepyrrolidine hydrochloride (41 · HCl), 2-(2,2-di(4-fluorophenyl)ethylene)-5,5-dimethyl-3-isopropylidenepyrrol idine hydrochloride (42 · HCl), (+)5,5-dimethyl-2-(N,N-diphenylaminomethyl)-3-isopropylidenepyrrolidin e hydrochloride (+)-(43a · HCl),(-)-5,5-dimethyl-2-(N,N-diphenylaminomethyl)-3-isopropylidenepyrr olidine hydrochloride (-)-(43a · HCl), and 2-(N,N-di(4-fluorophenyl)aminomethyl)-5,5-dimethyl-3-isopropylidenepyr rolidine methanesulfonate (43b · MsOH) showed stronger inhibitory activity on detrusor contraction than terodiline.

ACAT inhibitors

This invention relates to novel compounds which are ACAT inhibitors rendering them useful in lowering blood cholesterol levels. The compounds contain two urea or thiourea, amide, or amine moieties or combinations of said moieties and have the following general formula: wherein Ar is an aryl group, m and n are zero or one,W and YNH and form the urea, thiourea, amide or amine moieties.

ESR Spectroscopic Studies of Donor-Acceptor-Substituted Carbon Radicals

The radicals 2, 3a, 4, and 12 as well as 3b, and 17 were generated for ESR spectroscopic studies either by hydrogen abstraction with aminyl radicals or by oxidation with lead dioxide.Hydrogen abstraction from 5 did not give 6 but a secondary radical 7.Radical 16 was formed by reduction of the corresponding pyridinium iodide by zinc, whereas reduction of 13, and 8 afforded the radicals 15, and 11, respectively.The analysis of the ESR spectra allowed the determination of the spin density at various positions of these radicals.Furthermore, theoretical calculations of spin density - performed also for the radicals 1a and b, 21 and 22 - revealed the spin density distribution within the amino(cyano)alkyl group and the effects of further substituents on this.