36688-73-0

Basic information

• Product Name: N-(3-methoxyphenylethyl)acetamide
• Synonyms: N-(3-methoxyphenylethyl)acetamide
• CAS NO: 36688-73-0
• Molecular Weight: 193.246
• Mol File: 36688-73-0.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: N-(3-methoxyphenylethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methoxyphenylethyl)acetamide(36688-73-0)
• EPA Substance Registry System: N-(3-methoxyphenylethyl)acetamide(36688-73-0)

Safety Data

• Hazardous Substances Data: 36688-73-0(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 64-19-7 acetic acid 
• 108-05-4 vinyl acetate 
• 141-78-6 ethyl acetate 
• 3179-09-7 (E)-1-methoxy-3-(2-nitrovinyl)benzene 
• 72-89-9 acetylcoenzyme A 
• 75-36-5 acetyl chloride 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 1064199-05-8 2-(3-methoxybenzyl)-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 58246-80-3 1-(5-methoxy-1H-indol-1-yl)ethan-1-one 
• 1006-94-6 5-methoxylindole 
• 61562-93-4 6-hydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 74054-28-7 N-(2-bromo-5-methoxyphenethyl)acetamide 

Relevant articles and documents

Molecular structure effects in the asymmetric transfer hydrogenation of functionalized dihydroisoquinolines on (S,S)-[RuCl(η 6-p-cymene) TsDPEN]

The asymmetric transfer hydrogenation of five dihydroisoquinolines (DHIQs) was studied by NMR spectroscopy. The DHIQs differed by substitution with methoxy groups, which had a significant effect upon the reaction performance in terms of reaction rate and enantioselectivity. The differences are most probably related to the basicity of DHIQs.

Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation

A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming process for the preparation of a wide range of benzo-fused heterocyclic scaffolds using iron and copper catalysis is described. Activated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolecular N-or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogues. The general applicability and functional group tolerance of this method were exemplified by the total synthesis of the neolignan natural product, (+)-obtusafuran. DFT calculations using Fukui functions were also performed, providing a molecular orbital rationale for the highly regioselective arene iodination process.

Design and synthesis of sulfonamidophenylethylureas as novel cardiac myosin activator

To optimize the lead urea scaffold 1 and 2 as selective cardiac myosin ATPase activator, a series of urea derivatives have been synthesized to explore its structure activity relationship. Among them N,N-dimethyl-4-(2-(3-(3-phenylpropyl)ureido)ethyl)benzenesulfonamide (13, CMA = 91.6%, FS = 17.62%; EF = 11.55%), N,N-dimethyl-4-(2-(1-methyl-3-(3-phenylpropyl)ureido)ethyl)benzene sulfonamide (40, CMA = 52.3%, FS = 38.96%; EF = 24.19%) and N,N-dimethyl-4-(2-(3-methyl-3-(3-phenylpropyl)ureido)ethyl)benzenesulfonamide (41, CMA = 47.6%, FS = 23.19%; EF = 15.47%) proved to be efficient to activate the cardiac myosin in vitro and in vivo. Further the % change in ventricular cell contractility at 5 μM of 13 (47.9 ± 3.2), 40 (45.5 ± 2.4) and 41 (63.5 ± 2.2) showed positive inotropic effect in isolated rat ventricular myocytes. The potent compounds 13, 40, 41 were highly selective for cardiac myosin over skeletal and smooth muscle myosin, thus proving them these new urea derivatives is a novel scaffold for discovery of cardiac myosin activators for the treatment of systolic heart failure.