367-51-1

Usage

Uses

Used in Hair Industry:
Sodium thioglycolate is used as a depilatory agent for hair removal and as a key component in cold-waving of hair. It works by breaking the disulfide bonds in hair proteins, allowing the hair to be easily removed or styled.
Used in Bacteriology:
In bacteriology, sodium thioglycolate is used as a chelating agent for the preparation of thioglycolate media. This media is essential for the growth and maintenance of certain bacteria, making it a crucial component in bacterial research and analysis.
Used in Analytical Chemistry:
Sodium thioglycolate serves as an analytical reagent, particularly in the study of thioglycolic acid. Its chelating properties make it a valuable tool for various analytical processes.
Used in Enrichment Media:
As a growth supplement in enrichment media, sodium thioglycolate is used to study its effect on Arcobacter, a genus of bacteria. It helps in reducing disulfide-mediated cross-linking and early potency loss, which is particularly important in electron microscopy.
Used in Inflammation Hemagglutinin Formulation:
Sodium thioglycolate has been utilized in the formulation of influenza hemagglutinin to reduce disulfide-mediated cross-linking, which can lead to early potency loss. This application is significant in the development of vaccines and other medical treatments.

Air & Water Reactions

Hygroscopic. Discolors on exposure to air. Water soluble.

Reactivity Profile

Sodium thioglycolate is hygroscopic and sensitive to air. Discolors if exposed to iron . May generate flammable and toxic hydrogen sulfide with strong reducing agents.

Hazard

Yields toxic hydrogen sulfide on decompo- sition, may be toxic by skin absorption.

Fire Hazard

Flash point data for Sodium thioglycolate are not available. Sodium thioglycolate is probably combustible.

Flammability and Explosibility

Nonflammable

Biochem/physiol Actions

Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. A human skin irritant. This material yields hydrogen sulfide on decomposition. A death has been attributed to the absorption of toxic decomposition products from the use of this material in a hair permanent-waving solution. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFIDES and MERCAPTANS.

Purification Methods

It crystallises from 60% EtOH (charcoal). It is hygroscopic.[Beilstein 3 IV 600.]

InChI:InChI=1/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1

Upstream product

• 1310-73-2 sodium hydroxide 
• 68-11-1 mercaptoacetic acid 
• 79-11-8 chloroacetic acid 
• 140-93-2 sodium isopropylxanthate 
• 75-04-7 ethylamine 

Downstream Products

• 97800-37-8 ((2-Phenylhydrazono)-3-iminopropanenitrile)-S-thioacetic Acid 
• 5804-66-0 1-(2-Carboxymethylmercaptomethyl-4-nitro-phenoxy)-octan 
• 22216-44-0 2-(4-methoxy-3-nitrobenzylthio)acetic acid 
• 507264-57-5 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate 
• 63547-22-8 (benzhydrylthio)acetic acid 
• 1620289-16-8 7-[2-hydroxy-3-(4-tert-butyl)phenoxyprop-1-yl]-3-methylxanthinyl-8-thioacetic acid 
• 103-46-8 S-benzylmercaptoacetic acid 
• 109822-07-3 N-benzoyl-S-(2-carboxymethyl)dithiocarbamate 
• 101421-82-3 S-acetyl-4-mercaptobutyric acid 
• 60788-02-5 (2,5-Dioxo-1-phenyl-3-pyrrolidinylthio)-essigsaeure 
• 16111-22-1 2-(3-oxo-1,3-diphenylpropylsulfanyl)acetic acid 

Related news

Reevaluating the Sperm Nuclear Chromatin Decondensation Test by Sodium thioglycolate (cas 367-51-1) of Stallions Spermatozoa07/11/2019

The nucleus of mammalian spermatozoa is mainly composed of chromatin associated with protamines: highly basic proteins (around 7 kDa). These highly basic proteins, due to their cysteine content, can participate in the generation of disulfide bond. These characteristics permit typical condensed n...detailed

Relevant academic research and scientific papers

High-value utilization method of sodium 2-mercaptoacetate in thionocarbamate production tail liquid

The invention belongs to wastewater treatment, and particularly discloses a high-value utilization method of sodium 2-mercaptoacetate in thionocarbamate production tail liquid. According to the method, sodium 2-mercaptoacetate in the thionocarbamate production tail liquid is used as a raw material and reacts with thiocyanate and a halogenating reagent to obtain the S-carboxyethyl-N-alkanoyl dithiocarbamate. The method is simple to operate and high in efficiency, solves the problem that the sodium 2-mercaptoacetate in the thionocarbamate production tail liquid is difficult to recover, and can realize high-value utilization of the sodium 2-mercaptoacetate.

Pyrimido azacyclo compound and application thereof

The invention discloses a pyrimido azacyclo compound represented by a general formula I, and a pharmaceutically acceptable salt thereof, and relates to the technical field of organic chemistry, wherein substituent groups X and Ar are defined in the specification. The invention also relates to application of the compound represented by the general formula I and the pharmaceutically acceptable saltthereof in medicines for treating diseases caused by abnormal high expression of URAT1, particularly in preparation of medicines for treating and/or preventing gout, wherein the general formula I is defined in the specification.

Method for utilizing byproduct 2-sodium thioglycollate in production process of thionocarbamate

The invention belongs to wastewater treatment and in particular discloses a method for utilizing a byproduct 2-sodium thioglycollate in the production process of thionocarbamate. The method comprisesthe following steps: by taking a byproduct 2-sodium thioglycollate in the production process of thionocarbamate as a raw material, enabling the byproduct to react with a halogenation reagent so as toobtain alkyl thioether acetic acid; performing esterification on the alkyl thioether acetic acid with methanol so as to obtain alkyl thioether methyl acetate; and further enabling the alkyl thioethermethyl acetate to react with hydroxylamine hydrochloride, so as to obtain alkyl thioether ethyl hydroximic acid. By adopting the method, the problem that the byproduct 2-sodium thioglycollate in a process of thionocarbamate is hard to recycle can be solved, the utilization rate of the byproduct is increased, and the environment can be protected.

Production method of high-grade sodium thioglycollate powder

The invention provides a production method of high-grade sodium thioglycollate powder. The production method comprises the following steps of firstly, uniformly mixing chloroacetic acid and deionized water according to the mass ratio to obtain a chloroacetic acid solution, then adding sodium carbonate into the chloroacetic acid solution, and uniformly mixing to obtain a sodium chloroacetate solution; secondly, adding sodium thiosulfate into the sodium chloroacetate solution, uniformly mixing and then carrying out temperature-rise condensation to obtain a condensation compound; thirdly, adding sodium hydroxide into the condensation compound, uniformly mixing and then carrying out temperature-reduced mercaptoethylation to obtain a mercaptoethylation product; fourthly, carrying out vacuum drying treatment on the mercaptoethylation product to obtain the high-grade sodium thioglycollate powder. According to the production method provided by the invention, the problems about low grade of products, high transportation expenses, high packing expenses, easiness in oxidation and the like existing the prior art are solved; sodium thioglycollate produced by the production method provided by the invention is in a powder shape and does not generate three wastes; the grade of the product is over 35 percent; the high-grade sodium thioglycollate powder belongs to a green environment-friendly product.

COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA

Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.

ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS

Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND- HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.

COMPOSITION AND METHODS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME AND ACUTE MYELOID LEUKEMIA

Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: (I) wherein R1 is selected from the group consisting of -NH2, -NH-CH2-CO2H, -NH-CH(CH3)-CO2H, and -NH-C(CH3)2-CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.

Ambient stored blood plasma expanders

A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of, or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic alpha keratose preferred over acidic alpha keratose); and (b) an electrolyte solution, with the keratin derivative solubilized in the electrolyte solution to form a homogeneous liquid composition. Blood substitutes formed therefrom and methods of making and using the same are also described.

1,4-Oxathianones and 1,4-oxathiepanones

The compounds of the formula STR1 in which R is C1 -C24 alkyl, C3 -C20 alkenyl, C5 -C6 cycloalkyl, unsubstituted or C1 -C4 alkyl-substituted phenyl or phenyl-C1 -C4 alkyl, n is 1 or 2, and X is S or O, are highly suitable as additives, in particular as antiwear and high-pressure additives, and as corrosion inhibitors in functional fluids, for example in lubricants, fuels, hydraulic fluids, metal-working fluids and drilling fluids.