367-82-8Relevant academic research and scientific papers
Electrophilic ipso substitution of trimethylsilyl groups in fluorobenzenes
Coe, Paul L.,Stuart, Alison M.,Moody, David J.
, p. 27 - 32 (1998)
Using variants of literature methods 2,4- and 2,6- difluorophenyltrimethylsilanes have been bromodesilylated to the corresponding bromodifluorobenzenes in moderate to good yields, 3-bromo-2,6-difluorophenyltrimethylsilane afforded 1,3-dibromo-2,4-difluorobenzene whilst 1,3-difluoro-2,4-bis(trimethylsilyl)benzene yielded 3-bromo-2,6-difluorophenyltrimethylsilane. Application of either the Eaborn or Chvalovsky methods of nitrodesilylation to 4-fluorophenyltrimethylsilane, 2,4-difluorophenyltrimethylsilane and 2,6-difluorophenyltrimethylsilane afforded largely the corresponding desilylated products together with products associated with initial protodesilylation, followed by nitration of the resulting fluorobenzenes. The results obtained show that ipso desilylation in the fluoroaromatic series does follow the expected pattern previously obtained in the hydrocarbon analogues. They also show that in some cases the formation of unusually substituted fluoroarenes can be achieved more readily than by the methods previously used.
A 2 - (5 - fluoro - 2, 4 - two-nitrobenzene oxygen) acetate preparation method
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Page/Page column 5; 6, (2019/01/08)
The invention belongs to the field of organic synthetic technology, in particular to a 2 - (5 - fluoro - 2, 4 - two-nitrobenzene oxygen) acetate preparation method, comprises the following steps: step 1, to 2, 4 - difluoro nitrobenzene is used as raw mate
1,2 diarylbenzimdazoles and their pharmaceutical use
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, (2008/06/13)
Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
