36724-78-4Relevant articles and documents
Synthesis and Biochemical Evaluation of Nicotinamide Derivatives as NADH Analogue Coenzymes in Ene Reductase
Falcone, Natashya,She, Zhe,Syed, Jebreil,Lough, Alan,Kraatz, Heinz-Bernhard
, p. 838 - 845 (2019/02/07)
Nicotinamide and pyridine-containing conjugates have attracted a lot of attention in research as they have found use in a wide range of applications including as redox flow batteries and calcium channel blockers, in biocatalysis, and in metabolism. The interesting redox character of the compounds’ pyridine/dihydropyridine system allows them to possess very similar characteristics to the natural chiral redox agents NAD+/NADH, even mimicking their functions. There has been considerable interest in designing and synthesizing NAD+/NADH mimetics with similar redox properties. In this research, three nicotinamide conjugates were designed, synthesized, and characterized. Molecular structures obtained through X-ray crystallography were obtained for two of the conjugates, thereby providing more detail on the bonding and structure of the compounds. The compounds were then further evaluated for biochemical properties, and it was found that one of the conjugates possessed similar functions and characteristics to the natural NADH. This compound was evaluated in the active enzyme, enoate reductase; like NADH, it was shown to help reduce the C=C double bond of three substrates and even outperformed the natural coenzyme. Kinetic data are reported.
Synthesis and biological evaluation of novel hydrogen sulfide releasing nicotinic acid derivatives
Sun, Yinxing,Zhang, Yusuo,Li, Yuyao,Cheng, Jian,Chen, Shiyu,Xiao, Yunqi,Ao, Guizhen
, p. 5368 - 5373 (2016/10/24)
Twelve novel hybrids of slowly releasing hydrogen sulfide donor ADT-OH combined with nicotinic acid were synthesized. All of their structures had been confirmed by1H NMR,13C NMR and MS spectra. The target compounds were evaluated for their neuroprotective effects on hippocampal neuron HT22 cells against glutamate-induced injury at the concentrations of 1–100?μM with MTT assay, and their toxicity on HT22 cells untreated by glutamine at the concentration of 100?μM. The active compound was further investigated for its effect on ischemic infarct volume by intraperitoneal injection at 3?h after ischemia in mice models of permanent middle cerebral artery occlusion (pMCAO). The results showed that all the compounds significantly protected HT22 cells from glutamate-induced damage at most of the experimental concentrations, and had no or little neurotoxicity on normal HT22 cells at the high concentration. More importantly, compound A6 significantly reduced infarct volume in the pMCAO model. These results suggested that compound A6 may be promising for further evaluation for the intervention of cerebral ischemic injury.
Microwave-assisted formation of peptide-vitamin conjugates
El-Nachef, Claudia,Bajaj, Kiran,Koblick, Jacqueline,Katritzky, Alan R.
experimental part, p. 4412 - 4419 (2012/09/25)
Amino acid and peptide conjugates with vitamin B3, H, E and D3 were synthesized by using microwave irradiation in good to satisfactory yields. In addition, a novel benzotriazole-activated biotin intermediate has been introduced, whic
