36808-95-4Relevant academic research and scientific papers
Synthesis of 3-substituted indole by AlCl3-promoted reaction of β,γ-unsaturated ketone with indole
Lee, Adam Shih-Yuan,Wu, Yu-Chi,Chang, Yu-Ting,Wang, Bo-Cheng
, p. 2277 - 2285 (2014/06/24)
A one-pot Lewis acid-promoted reaction condition of β,γ- unsaturated ketone with indole was developed for the synthesis of 3-substituted indoles with moderate to good yields. A Lewis acid such as AlCl3 was shown to be a promising promoter for in situ isomerization of β,γ-unsaturated ketone to its corresponding α,β- unsaturated ketone, then undergoing Friedel-Crafts Michael addition reaction with indole to afford 3-substituted indole.
A mild isomerization reaction for β,γ-unsaturated ketone to α,β-unsaturated ketone
Lee, Adam Shih-Yuan,Lin, Mei-Chun,Wang, Shu-Huei,Lin, Li-Shin
, p. 371 - 376 (2015/02/05)
A series of β,γ-unsaturated ketones were isomerized to their corresponding α,β-unsaturated ketones by the introduction of DABCO in iPrOH at room temperature. The endo-cyclic double bond (β,γ-position) on ketone was rearranged to exo-cyclic double bond (α,β-position) under the reaction conditions.
FACILE SYNTHESIS OF BENZYL KETONES BY THE REDUCTIVE COUPLING OF BENZYL BROMIDE AND ACYL CHLORIDES IN THE PRESENCE OF A PALLADIUM CATALYST AND ZINC POWDER
Sato, Toshio,Naruse, Kouichi,Enokiya, Masashi,Fujisawa, Tamotsu
, p. 1135 - 1138 (2007/10/02)
Benzyl ketones were obtained in good yields from benzyl bromide and acyl chlorides by the combined use of Zn and a palladium catalyst under mild conditions.
