36951-42-5

Upstream product

• 4334-74-1 4-methoxybenzylidene thiosemicarbazone 
• 79-11-8 chloroacetic acid 
• 2299-73-2 N,N-bis(4-methoxybenzylidene)hydrazine 
• 5349-28-0 thiocyanato-acetic acid ethyl ester 
• 7147-50-4 N¹,N⁵-di(p-methoxybenzylidene)thiocarbohydrazide 
• 105-36-2 ethyl bromoacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 51236-65-8 C₉H₁₂N₄OS 
• 119023-40-4 3-{[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-amino}-2-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazono}-thiazolidin-4-one 
• 125611-81-6 3-Amino-2-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazono}-thiazolidin-4-one 
• 71299-80-4 2-(2-cyclohexylidenehydrazono)thiazolidin-4-one 

Downstream Products

• 71299-76-8 4-methoxy-benzaldehyde [5-(4-hexyloxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 71299-77-9 4-methoxy-benzaldehyde [5-(4-heptyloxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 71299-78-0 4-methoxy-benzaldehyde [5-(4-octyloxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 71299-79-1 4-methoxy-benzaldehyde [5-(4-nonyloxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 71299-72-4 4-methoxy-benzaldehyde [5-(4-ethoxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 36951-49-2 4-methoxy-benzaldehyde [5-(4-methoxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 71299-75-7 4-methoxy-benzaldehyde [4-oxo-5-(4-pentyloxy-benzylidene)-thiazolidin-2-ylidene]-hydrazone 
• 71299-73-5 4-methoxy-benzaldehyde [4-oxo-5-(4-propoxy-benzylidene)-thiazolidin-2-ylidene]-hydrazone 
• 71299-74-6 4-methoxy-benzaldehyde [5-(4-butoxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 36951-49-2 4-methoxy-benzaldehyde [5-(4-methoxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 494582-99-9 3-(4-methoxy-phenyl)-1-(4-oxo-4,5-dihydro-thiazol-2-yl)-5-phenyl-tetrahydro-pyrrolo[3,4-c]pyrazole-4,6-dione 
• 494583-17-4 3-(4-methoxy-phenyl)-1-(4-oxo-4,5-dihydro-thiazol-2-yl)-5-p-tolyl-tetrahydro-pyrrolo[3,4-c]pyrazole-4,6-dione 
• 494583-06-1 5-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-(4-oxo-4,5-dihydro-thiazol-2-yl)-tetrahydro-pyrrolo[3,4-c]pyrazole-4,6-dione 
• 494583-64-1 5-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-1-(4-oxo-4,5-dihydro-thiazol-2-yl)-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors

Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 inhibitory activity. Compound 2-(2-(5-bromo-2-hydroxybenzylidene)hydrazinyl)thiazol-4(5H)-one (12) displayed the most potent inhibitory activity (IC50 = 0.09 μM for EGFR and IC50 = 0.42 μM for HER-2), comparable to the positive control erlotinib. Docking simulation was performed to position compound 12 into the EGFR active site to determine the probable binding model. Antiproliferative assay results indicating that some of the thiazolidinone derivatives own high antiproliferative activity against MCF-7. Compound 12 with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent.

Synthesis and Structure of Some Thiazole Derivatives

The addition of thiosemicarbazones 1 to α-halo acids 2 is shown to give 2-hydrazino-2-thiazolin-4-ones 3 and not 3-substituted 2-imino-3-(methyleneimino)thiazolidin-4-ones 4.The independent synthesis of 2-thiazolin-4-one derivatives 3 is also described.