370-22-9

Usage

Uses

Used in Chemical Research:
1,3-Bis(4-fluorophenyl)urea, 97% is used as a research compound for its unique molecular structure and properties, allowing scientists to study its interactions with other molecules and its potential applications in various chemical processes.
Used in Pharmaceutical Research:
1,3-Bis(4-fluorophenyl)urea, 97% is used as a starting material or intermediate in the synthesis of pharmaceutical compounds, taking advantage of its stability and reactivity. Its potential as a therapeutic agent is being explored in the development of new drugs.
Used in Material Science:
1,3-Bis(4-fluorophenyl)urea, 97% is used as a component in the development of new materials, such as polymers or coatings, due to its unique chemical properties and potential to enhance the performance of these materials.
Used in Analytical Chemistry:
1,3-Bis(4-fluorophenyl)urea, 97% is used as a reference compound or standard in analytical chemistry, particularly in techniques such as chromatography or spectroscopy, to help identify and quantify other compounds in a sample.

InChI:InChI=1/C13H10F2N2O/c14-9-1-5-11(6-2-9)16-13(18)17-12-7-3-10(15)4-8-12/h1-8H,(H2,16,17,18)

Upstream product

• 351-74-6 bis(4-fluorophenyl)methanediimine 
• 107-97-1 sarcosine 
• 1195-45-5 para-fluorophenyl isocyanate 
• 2935-90-2 Methyl 3-mercaptopropionate 
• 126521-82-2 hexaamino-benzene trihydrochloride 
• 371-40-4 4-fluoroaniline 
• 141-97-9 ethyl acetoacetate 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 98-95-3 nitrobenzene 
• 459-56-3 4-fluorobenzylic alcohol 
• 201230-82-2 carbon monoxide 
• 459-57-4 4-fluorobenzaldehyde 
• 67-66-3 chloroform 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 86488-77-9 C₁₃H₉F₂N₃O₂ 
• 569-81-3 N-(4-fluorophenyl)phthalimide 
• 371-40-4 4-fluoroaniline 
• 1960-13-0 1-({4-fluorophenyl}diazenyl)naphthalen-2-ol 
• 141417-89-2 N,N’-bis(4-fluorophenyl)formamidine 
• 351-74-6 bis(4-fluorophenyl)methanediimine 

Relevant academic research and scientific papers

Amide-assisted rearrangement of hydroxyarylformimidoyl chloride to diarylurea

A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.

Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N′-disubstituted urea/thiourea motifs from isothiocyanates in water

ABATRACT: A direct approach to N,N′-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N′-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-butyl peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies.

Palladium-Catalyzed Aerobic Oxidative Carbonylation of Amines Enables the Synthesis of Unsymmetrical N,N′-Disubstituted Ureas

A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines for the synthesis of ureas, particular unsymmetrically N,N′-disubstituted ureas, which cannot be accessed by any other palladium-catalyzed oxidative carbonylation of amines to date, is presented. An array of symmetrical and unsymmetrical ureas were straightforwardly synthesized by using inexpensive, readily available, stable, and safe amines with good to excellent yields under a pressure of 1 atm. This novel method employs oxygen as the sole oxidant and offers an attractive alternative to transition-metal-based oxidant systems.

Method for preparing symmetric urea compound

The invention provides a novel reaction system for synthesizing a symmetric urea compound by taking CO2 as a carbonylation reagent, wherein Lewis base and hydrosilane are used as accelerators and efficiently enable an aromatic/aliphatic primary amine compound to react with normal-pressure CO2 to generate corresponding symmetric urea compounds containing different functional groups under mild conditions (100 DEG C, diglyme). According to the method, normal-pressure CO2 is used as an environmentally-friendly non-toxic carbonylation reagent, and cheap Lewis base and PMHS (industrial silicon waste) are used as accelerators, so that the use of toxic carbonylation reagents, isocyanate, high-pressure CO2, expensive dehydrating agents and precious metals is avoided, purification and separation ofintermediates are not needed, pure products can be obtained only through simple suction filtration and separation after the reaction is finished, and the method is an efficient and novel synthesis method and has high industrial application value.

Hydrosilane-Assisted Synthesis of Urea Derivatives from CO2and Amines

A methodology employing CO2, amines, and phenylsilane was discussed to access aryl- or alkyl-substituted urea derivatives. This procedure was characterized by adopting hydrosilane to promote the formation of ureas directly, without the need to prepare silylamines in advance. Control reactions suggested that FeCl3 was a favorable additive for the generation of ureas, and this 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed reaction might proceed through nucleophilic addition, silicon migration, and the subsequent formal substitution of silylcarbamate.

Catalytic conversions of isocyanate to urea and glucose to levulinate esters over mesoporous α-Ti(HPO4)2·H2O in green media

We have described a facile solvothermal synthesis of a sheet-like α-Ti(HPO4)2·H2O nanomaterial. The material comprises 10.7 nm nanoparticles along with ordered mesopores throughout its hexagonal building blocks. The material possesses a bandgap of 3.86 eV and works as an efficient catalyst for the selective synthesis of ureas from a broad range of isocyanates in the presence of H2O at room temperature with a high product yield (up to 93%) and a TOF value up to 15.25 h-1. The α-Ti(HPO4)2·H2O nanomaterial also catalytically converts glucose to levulinic acid (LA) and subsequently LA to alkyl levulinates in the presence of different alcohols with a high product yield (up to 98%) and a TOF value up to 43.00 h-1. Furthermore, all the reactions are performed under green and facile catalytic conditions without using any hazardous solvent. The α-Ti(HPO4)2·H2O catalyst material was also found to be reusable for manifold cycles for all the reactions, keeping its catalytic efficiency along with its structural and morphological characteristics unaffected, supporting its industrial relevance.

N,N'-disubstituted urea compound and synthesis method thereof

The invention discloses an N,N'-disubstituted urea compound and a preparation method thereof. N-alkyl acyloxy amide is taken as a raw material and a dichloro(p-cymene)ruthenium(II) dimer complex is taken as a catalyst for carrying out a reaction in an organic solvent under the presence of silver acetate, and the N,N'-disubstituted urea compound is prepared. Compared with the prior art, the methodhas the following advantages that only an amide derivative is taken as a raw material, reaction conditions are mild, the application range of substrates is wide, operation is simple and convenient, the catalyst is low in price, and selectivity of the product is high.

Pd/C-Catalyzed Domino Synthesis of Urea Derivatives Using Chloroform as the Carbon Monoxide Source in Water

A Pd/C-catalyzed domino synthesis of symmetrical and unsymmetrical ureas from aryl iodides, sodium azide, amines and CHCl3 in water has been developed. This reaction proceeds with sequential carbonylation, Curtius rearrangement and nucleophilic addition. CHCl3 serves as a convenient and safe alternation of CO gas in the presence of KOH. A series of urea derivatives were obtained in moderate to good yields with good functional group tolerance. Furthermore, the Pd/C catalyst could be readily recovered with slight decrease in the catalytic activity after six consecutive runs. (Figure presented.).

Effective approach to ureas through organocatalyzed one-pot process

An efficient approach to N, N′-unsymmetrically substituted ureas 9 has been developed through the ammonolysis process of N-Boc protected anilines 7 with amines prompted by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). Moreover, a convenient protocol for the

Diaryl urea compound synthesis method

The invention discloses a synthesis method of diarylurea compounds. The synthesis method comprises the following steps: adding a phenylamine compound shown in a formula II and bis(trichloromethyl) carbonic ester into a reaction solvent and reacting for 1-2h at 0-5 DEG C; then, adding a ETS-10 molecular sieve based catalyst, heating to 70-100 DEG C to react, performing tracking detection by virtue of TLC till the reaction is complete; and performing posttreatment on reaction liquid to obtain a diarylurea compound shown in formula I. The synthesis method has the advantages that the raw material conversion rate is 100%, the yield is 95% or above, the product purity is high, the used catalyst is nontoxic and odorless and can be reused, and therefore cost is saved. (The formulas I and II are shown in the specification.).