3708-35-8

Basic information

• Product Name: Propanedioic acid, (3-phenyl-2-propenyl)-, diethyl ester
• CAS NO: 3708-35-8
• Molecular Formula: C16H20O4
• Molecular Weight: 276.332
• Mol File: 3708-35-8.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (3-phenyl-2-propenyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (3-phenyl-2-propenyl)-, diethyl ester(3708-35-8)
• EPA Substance Registry System: Propanedioic acid, (3-phenyl-2-propenyl)-, diethyl ester(3708-35-8)

Safety Data

• Hazardous Substances Data: 3708-35-8(Hazardous Substances Data)

Upstream product

• 34727-00-9 lithium diethyl malonate 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 36195-56-9 (E)-but-2-en-1-yl phenyl sulfide 
• 105-53-3 diethyl malonate 
• 5848-60-2 (E)-1-phenyl-3-(phenylthio)propene 
• 16215-11-5 trans-cinnamyl p-tolyl sulfone 
• 69562-10-3 1-phenyl-3-phenylseleno-1-propene 
• 103-54-8 cinnamyl acetate 
• 85217-69-2 cinnamyl methyl carbonate 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 
• 2687-12-9 cinnamyl chloride 
• 66684-75-1 diethyl 2-[3-phenylprop-2-en-1-ylidene]propanedioate 
• 4392-24-9 Cinnamyl bromide 
• 104-54-1 3-Phenylpropenol 

Downstream Products

• 3708-36-9 C₁₂H₁₂O₄ 
• 134039-00-2 N-Methyl-5-phenyl-4-pentenamide 
• 134025-24-4 2-Benzyl-1,4-dimethylpyrrolidine 
• 134025-22-2 N-Methyl-2-methyl-5-phenylpent-4-enylamine 
• 24285-20-9 N-Methyl-5-phenylpent-4-enylamine 
• 4266-03-9 N-Methyl-2-(phenylmethyl)pyrrolidine 
• 24332-55-6 diethyl 2-cinnamyl-2-methylmalonate 
• 17920-83-1 5-phenyl-4-pentenoic acid 
• 3708-36-9 trans-cinnamylmalonic acid 

Relevant articles and documents

Sustainable Palladium-Catalyzed Tsuji-Trost Reactions Enabled by Aqueous Micellar Catalysis

Palladium-catalyzed allylic substitution, or "Tsuji-Trost"reactions, can be run under micellar catalysis conditions featuring not only chemistry in water but also numerous combinations of reaction partners that require low levels of palladium, typically on the order of 1000 ppm (0.1 mol %). These couplings are further characterized by especially mild conditions, leading to a number of cases not previously reported in an aqueous micellar medium. Inclusion of diverse nucleophiles, such as N-H heterocycles, alcohols, dicarbonyl compounds, and sulfonamides is described. Intramolecular cyclizations further illustrate the broad utility of this process. In addition to recycling studies, a multigram scale example is reported, indicative of the prospects for scale up.

MMZNiY-Catalyzed Tsuji–Trost Type of Reaction: A Selective Mono/Bis Allylation of Dicarbonyl Compounds

Abstract: An alternative method to Pd-catalyzed Tsuji–Trost reaction is developed and it provides a simpler route for the selective synthesis of a broad range of mono-/bis-allylated and cinnamylated 1,3-dicarbonyl compounds using MMZNiY catalyst at room temperature. Product selectivity can be controlled by the proper choice of catalyst. The catalyst was also well characterized by SEM, TEM, HRTEM, EDAX and X-ray analysis. Other advantages of catalyst like its ease of preparation, functional tolerance and its reusability are also highlighted.

Palladium-Catalyzed highly diastereoselective oxidative cascade cyclization reactions

Isoquinoline and quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)2/isoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C-N bond and two C-C bonds are formed in a single step with excellent diastereoselectivities (dr> 24:1).