3721-85-5Relevant articles and documents
D-2-AMINOPIMELIC ACID AND TRANS-3,4-DEHYDRO-D-2-AMINOPIMELIC ACID FROM ASPLENIUM UNILATERALE
Murakami, Noriaki,Hatanaka, Schin-Ichi
, p. 2735 - 2738 (1983)
D-2-Aminopimelic acid and a novel amino acid, trans-3,4-dehydro-D-2-aminopimelic acid were isolated and characterized from Asplenium unilaterale.Their distribution in Aspleniaceae was also investigated. - Key Word Index: Asplenium unilaterale; Aspleniaceae; (R)-2-aminoheptanedioic acid; (E)-(R)-2-amino-3-heptenedioic acid; D-amino acids; stereochemistry; chemotaxonomy.
GADD45BETA TARGETING AGENTS
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, (2012/11/08)
Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.
Inhibitors selective for HDAC6 in enzymes and cells
Gupta, Praveer K.,Reid, Robert C.,Liu, Ligong,Lucke, Andrew J.,Broomfield, Steve A.,Andrews, Melanie R.,Sweet, Matthew J.,Fairlie, David P.
supporting information; experimental part, p. 7067 - 7070 (2011/01/03)
Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages.
PREPARATION OF 6-AMINOCAPROIC ACID FROM α-KETOPIMELIC ACID
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Page/Page column 45-46, (2009/10/22)
The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as '6-ACA')usinga biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as 'caprolactam') by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotidewhich may be used inthe preparation of 6-ACA or caprolactam.
INHIBITORS OF KYNURENINE AMINOTRANSFERASE AND USES THEREFOR
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Page/Page column 21, (2008/06/13)
Provided herein are methods of decreasing a level of kynurenic acid in a cell and of treating a pathophysiological condition in a subject associated with an increase in kynurenic acid in a subject. In these methods the inhibitory action of dicarboxylic acids or derivatives or analogs thereof are effective to inhibit activity of kynurenine aminotransferase II. Also provided is a method of screening for potential inhibitory compounds for kynurenine aminotransferase II. The dicarboxylic acids or derivatives or analogs thereof may have the structural formula, where R1 is H, NH2 or NHCH3, R2 is H or CH3, n is 0 to 14, and X is -COOH, CH2OH, -PO3H2, -SO2H, or -SO3H; or a pharmacologically acceptable salt.
Practical and efficient enantioselective synthesis of α-amino acids in aqueous media
Suarez, Rosa M.,Sestelo, Jose Perez,Sarandeses, Luis A.
, p. 3584 - 3587 (2007/10/03)
Enantiomerically pure natural and unnatural α-amino acids have been synthesized from a chiral melhyleneoxazolidinone by means of a highly diastereoselective 1,4-conjugate addition of alkyl iodides in aqueous media. The zinc-copper conjugate addition reaction exhibits high chemoselectivity, with the possibility of using functionalized iodides, to afford a single diastereomer in short reaction times and with good yields.
Peptides with an insulin-like action
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, (2008/06/13)
Peptides with an insulin-like action, of formula I: STR1 in which G is a hydrogen atom, an amino add residue, or a monosubstituted or polysubstituted amino acid; D is an amino acid residue, a phosphoamino acid residue, a monosaccharide residue, or a covalent bond; E is --NH--(CH2)n --NR52, a glycerol residue, or --NH--(CH2)p --R6 --R7 ; R1 is (C1 -C4)-alkyl or =O; R2 is a sulfhydryl protecting group, (C1 -C3)-alkyl, or a hydrogen atom; R3 and R4, independently of one another, are a hydrogen atom or methyl; R5, each being identical or different, is a hydrogen atom, 1 to 6 monosaccharide residues, or 1 to 6 monosubstituted or polysubstituted monosaccharide residues; R6 is O PO4 H, PO2 H, NHCOO, S or OCOO; R7 is a hydrogen atom, 1 to 6 monosaccharide residues, or 1 to 6 monosubstituted or polysubstituted monosaccharide residues; w is an integer 1 or 2; their preparation and use for treatment of diabetes mellitus or insulin-independent diabetes.
Peptides of 2-aminopimelic acid: Antibacterial agents that inhibit diaminopimelic acid biosynthesis
Berges,DeWolf Jr.,Dunn,Grappel,Newman,Taggart,Gilvarg
, p. 89 - 95 (2007/10/02)
Succinyl-CoA:tetrahydrodipicolinate-N-succinyltransferase is a key enzyme in the biosynthesis of diaminopimelic acid (DAP), a component of the cell wall peptidoglycan of nearly all bacteria. This enzyme converts the cyclic precursor tetrahydrodipicolinic
alpha -AMINO ACIDS AS CHIRAL EDUCTS FOR ASYMMETRIC PRODUCTS. A GENERAL SYNTHESIS OF D- alpha -AMINO ACIDS FROM L-SERINE.
Maurer,Takahata,Rapoport
, p. 1095 - 1098 (2007/10/02)
A short and chirally efficient synthesis of four D- alpha -amino acids is described with L-serine as the chiral educt. The key C-C bond-forming reactions are the aminoacylations of organometallics with the lithium salt of N-(phenylsulfonyl)-L-serine (2) to give optically pure N-blocked alpha -amino ketones. Reduction of the carbonyl group to carbinol or methylene followed by oxidation of the hydroxymethyl to carboxyl gives the N-blocked D-amino acids. The examples investigated (norleucine, alpha -aminopimelic acid, DOPA, and allothreonine) demonstrate the broad applicability of the method.
