3723-23-7Relevant academic research and scientific papers
Synthesis of some derivatives of 4,5-dihydrooxazoles
Piri, Farideh,Ghaforinia, Nastaran,Taghavi, Mohammad,Karimian, Ramin
experimental part, p. 1403 - 1406 (2012/04/10)
Benzaldehyds with sodium amide in the presence of thiourea in tetrahydro furan at room temperature gave various 2,4,5-triphenyl-4,5-dihydrooxazoles. The thiourea-catalyzed condensation of the benzaldehyde yielded 2-amino-1,2- diphenylethanone. Reduction of 2-amino-1,2-diphenylethanone was performed with hydride from Cannizzaro reaction to give 2-amino-1,2-diphenylethanols. The 4,5-dihydrooxazole ring formation of the 2-amino-1,2-diphenylethanol and benzamide gave the desired 4,5-dihydrooxazole.
Carbon Dioxide. A Reagent for the Protection of Nucleophilic Centers and the Simultaneous Activation for Electrophilic Attack. Part 4. The α-Substitution of (i) Benzyl Alcohol and (ii) Benzylamine
Katritzky, Alan R.,Fan, Wei-Qiang,Akutagawa, Kunihiko
, p. 415 - 418 (2007/10/02)
Benzyl alcohol is converted into a variety of α-substituted derivatives by a one-pot sequence involving lithiation of an intermediate hemicarbonate ester.Benzylamine is similarly converted by a one-pot sequence to α-substituted benzylamines: here an intermediate carbamate salt is involved.
