3739-83-1

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 71-23-8 propan-1-ol 
• 1450-85-7 2-thioxopyrimidine 
• 67-63-0 isopropyl alcohol 
• 15718-46-4 2,2'-dipyrimidyl disulfide 
• 14080-23-0 2-cyanopyrimidine 

Downstream Products

• 557-01-7 Pyrimidin-2(1H)-one 
• 74-85-1 ethene 

Relevant academic research and scientific papers

Metal- And Oxidant-Free Electrochemical Oxidative Desulfurization C-O Coupling of Thiourea-Type Compounds with Alcohols

An efficient desulfurization C-O coupling reaction of 3,4-dihydropyrimidine-2(1 H)-thiones (including thioureas) with alcohols was developed under electrochemical oxidation conditions. Herein, transition--metal catalysts and additives are not required and

Decyanative Cross-Coupling of Cyanopyrimidines with O-, S-, and N-Nucleophiles: A Route to Alkoxylpyrimidines, Aminopyrimidines and Alkylthiopyrimidines

The transition metal-free cross-coupling reactions of cyanopyrimidines with aliphatic alcohols, thiols (or S-alkylisothiourea salts) and amines, giving the corresponding alkoxylpyrimidines, aminopyrimidines, and alkylthiopyrimidines, are reported. Prelimi

3-(Heteroaryal) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4

Disclosed are certain 3-(heteroaryl)alanine derivatives which bind VLA-4 and inhibit leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

The Mechanism of Thermal Eliminations. Part 20. The Relative Rates of Pyrolysis of the 2-Ethoxy, 2-Isopropoxy, and 2-t-Butoxy Derivatives of Pyrazine and Pyrimidine to Pyrazine-2-one, pyrimidin-2-one, respectively: Polarity of the Transition States and the Importance of Nucleophilic ...

We have measured rates of thermal elimination of the title compounds to give the corresponding cyclic amides, between 587.0 and 698.5 K.The relative rates (primary:secondary:tertiary) at 600 K are 1:27.0:3720 for the pyrazines, and 1:26.4:4150 for the pyrimidines.These ratios are somewhat larger than for the corresponding 2-alkoxypyridines and suggest that C-O bond breaking is kinetically more significant in the pyrazines and pyrimidines, leading to a transition state with greater carbocationic character.This is consistent with electron withdrawal provided by the aza 'substituent' facilitating C-O bond cleavage.It does not however lead to a general increase in reactivity (as would be the case for pyrolysis of comparable esters) because this electron withdrawal reduces the nucleophilicity of the nitrogen involved in the elimination.This latter is particularly important for the primary and secondary compounds (which have more Ei-like transition states) than for the tertiary compounds, which therfore show a normal reactivity vs. rate spread pattern.The importance of the nucleophilicity of the nitrogen in the alkoxy-heterocycles, and its ability to be modified, may stem in part from the dual pathway available for transmission of substituent effects in the aromatic ring.