169504-53-4

Basic information

• Product Name: 3,4-dihydro-1-[(4-methoxyphenyl)methyl]-1H-1,4-Benzodiazepine-2,5-dione
• Synonyms: 3,4-dihydro-1-[(4-methoxyphenyl)methyl]-1H-1,4-Benzodiazepine-2,5-dione;1-(4-Methoxybenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-one;1-(4-Methoxybenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
• CAS NO: 169504-53-4
• Molecular Formula: C₁₇H₁₆N₂O₃
• Molecular Weight: 296
• Mol File: 169504-53-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.253
• CAS DataBase Reference: 3,4-dihydro-1-[(4-methoxyphenyl)methyl]-1H-1,4-Benzodiazepine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydro-1-[(4-methoxyphenyl)methyl]-1H-1,4-Benzodiazepine-2,5-dione(169504-53-4)
• EPA Substance Registry System: 3,4-dihydro-1-[(4-methoxyphenyl)methyl]-1H-1,4-Benzodiazepine-2,5-dione(169504-53-4)

Safety Data

• Hazardous Substances Data: 169504-53-4(Hazardous Substances Data)

Usage

General Description

3,4-dihydro-1-[(4-methoxyphenyl)methyl]-1H-1,4-Benzodiazepine-2,5-dione, also known as flurazepam, is a benzodiazepine medication that is commonly prescribed for the treatment of insomnia. It works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which helps to reduce the overactivity of certain brain cells and induce a calming effect. Flurazepam is classified as a long-acting benzodiazepine, meaning that it has a relatively long half-life and can remain in the body for an extended period of time. Due to its potential for abuse and addiction, as well as its sedative effects, flurazepam is typically prescribed for short-term use and should be used with caution, especially in individuals with a history of substance abuse or in conjunction with other central nervous system depressants.

Upstream product

• 5363-29-1 2-(4-methoxybenzylamino)benzoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 16512-74-6 1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 56-40-6 glycine 
• 118-92-3 anthranilic acid 
• 5118-94-5 1,4-benzodiazepine-2,5-dione 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1271523-27-3 [1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester 
• 1351764-56-1 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-((4,6-dimethylpyrimidin-2-yl)methoxy)-5-fluoronicotinamide 
• 1351764-55-0 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-((5-methoxy-2-methylpyrimidin-4-yl)methoxy)nicotinamide 
• 1351764-54-9 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-4-ylmethoxy)nicotinamide 
• 1351764-53-8 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-((2-(pyrimidin-2-yl)propan-2-yl)oxy)nicotinamide 
• 1351764-52-7 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide 
• 1351764-51-6 (R)-N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-2-ylmethoxy)nicotinamide 
• 1351764-49-2 (S)-N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-2-ylmethoxy)nicotinamide 
• 1351764-04-9 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-2-ylmethoxy)nicotinamide 
• 1351763-65-9 2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide 
• 1351763-82-0 5-fluoro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(pyridin-4-ylmethoxy)nicotinamide 
• 1351764-50-5 (S)-N-(5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-2-ylmethoxy)nicotinamide 
• 1351281-45-2 3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one 
• 1351281-46-3 (S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one 

Relevant articles and documents

BENZODIAZEPINE COMPOUNDS USEFUL FOR THE TREATMENT OF HEPATITIS C

The invention concerns benzodiazepine derivatives of Formula (I) wherein A, X, L1, L2, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection.