37895-88-8Relevant academic research and scientific papers
Design, synthesis and antibacterial evaluation of 2-alkyl- and 2-aryl-3-(phenylamino)quinazolin-4(3H)-one derivatives
Mohammadi, Ali Asghar,Ahdenov, Reza,Abolhasani Sooki, Ali
, p. 105 - 108 (2017/04/14)
2-Alkyl and 2-aryl-3-(phenylamino)quinazolin-4(3H)-ones 4a-h were synthesized in a one-pot three-component condensation of an isatoic anhydride 1a-h, ethyl or methyl ortho ester and phenylhydrazine in the presence of KAl(SO4)2·12H2O (alum) as a nontoxic, reusable, inexpensive and easily available catalyst. The synthesis was conducted under microwave irradiation or classical heating. Products 4a and 4b show good antimicrobial activities.
Palladium-Catalyzed Cascade Reaction of 2-Amino-N′-arylbenzohydrazides with Triethyl Orthobenzoates To Construct Indazolo[3,2-b]quinazolinones
Yang, Weiguang,Qiao, Rui,Chen, Jiuxi,Huang, Xiaobo,Liu, Miaochang,Gao, Wenxia,Ding, Jinchang,Wu, Huayue
, p. 482 - 489 (2015/08/18)
A palladium-catalyzed sequential cyclization/C-H activation cascade reaction of 2-amino-N′-arylbenzohydrazides with triethyl orthobenzoates has been developed, providing indazolo[3,2-b]quinazolinones in good to high yields. Two key intermediates of the re
Pd-catalyzed intramolecular aerobic oxidative C-H amination of 2-aryl-3-(arylamino)quinazolinones: Synthesis of fluorescent indazolo[3,2-b]quinazolinones
Yang, Weiguang,Chen, Jiuxi,Huang, Xiaobo,Ding, Jinchang,Liu, Miaochang,Wu, Huayue
, p. 5418 - 5421 (2015/02/19)
A palladium-catalyzed intramolecular aerobic oxidative C-H amination of 2-aryl-3-(arylamino)quinazolinones has been developed, providing a variety of substituted indazolo[3,2-b]quinazolinone derivatives in moderate to excellent yields. Preliminary mechani
Evaluation of antibacterial activity of novel quinazoline derivatives
Tiwari, Ravi,Chhabra, Gurmeet
experimental part, p. 5981 - 5986 (2010/12/24)
In the present study, a series of novel quinazoline derivatives were synthesized by condensation with different aromatic amines via cyclized intermediate 2-phenyl-1,3-benzoxazin-4-one. The chemical structures were confirmed by means of IR and 1H NMR. These compounds were screened for antibacterial (Staphylococcus aureus ATCC-9144, Escherichia coli ATCC-25922, activities by paper disc diffusion technique. The potency of antibiotic content in samples can be determined by chemical, physical or biological means. An assay is made to determine the ability of an antibiotic to kill or inhibit the growth of living microorganism. The inhibition of microbial growth under standardized conditions may be utilized for demonstrating the therapeutic efficacy of drugs. Microorganism employed in biological assay are of various typesbacteria for amino acid, antibiotics, fungi for vitamins, trace elements, antibiotics and fungicidal and fungi static materials. The synthesized compounds were evaluated for antibacterial activity. Some of these synthesized compounds shown significant antibacterial activity.
