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Upstream product

• 21615-34-9 2-Methoxybenzoyl chloride 
• 60681-96-1 2-(2-methoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 50625-52-0 2-bromo-N'-phenylbenzohydrazide 
• 4001-73-4 2-Bromobenzamide 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 100-63-0 phenylhydrazine 
• 102079-45-8 3-(phenylamino)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one 
• 30086-49-8 2-amino-N'-phenylbenzohydrazide 
• 1663-61-2 triethoxymethylbenzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 26260-02-6 2-iodobenzaldehyde 
• 118-48-9 isatoic anhydride 
• 552-89-6 2-nitro-benzaldehyde 
• 18595-86-3 2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one 

Relevant academic research and scientific papers

Method for preparing indazolo [3, 2-b] quinazole-7 (5H)-ketone derivative based on Ullmann coupling reaction

The invention discloses a method for preparing an indazolo [3, 2-b] quinazole-7 (5H)-ketone derivative based on Ullmann coupling reaction, and belongs to the technical field of organic synthesis and medicines. Pre-prepared o-bromobenzoyl hydrazine is used as a substrate raw material, under the action of a copper catalyst, the substrate raw material and o-bromobenzamide are heated to perform Ullmann coupling reaction to construct a C-N bond, and the indazolo [3, 2-b] quinazole-7 (5H)-ketone derivative is efficiently synthesized by a one-pot method. The raw materials are simple and easy to obtain, the reaction system is simple and convenient to operate, the reaction is efficient, and a novel green and environment-friendly synthesis method with wide substrate universality is provided for preparation of the nitrogen heterocyclic compound.

Copper-catalyzed efficient synthesis of 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones from 2-nitrobenzaldehydes

A novel and practical copper-catalyzed approach was developed for the preparation of 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones. The 2-amino-N′-arylbenzohydrazideis easily prepared by a reaction of isatoic anhydride with arylhydrazine. Then, through a con

Copper-catalyzed C-O bond cleavage and cyclization: synthesis of indazolo[3,2-b]quinazolinones

The first example of a copper-catalyzed halogen-free protocol to construct indazolo[3,2-b]quinazolinones was developed through sequential inert C-O bond cleavage followed by intramolecular C-N bond formation. This protocol represents an efficient synthetic tool for accessing a more diverse range of functionalized indazolo[3,2-b]quinazolinones. The structure of the newly synthesized indazolo[3,2-b]quinazolinones was unambiguously confirmed by X-ray crystal diffraction analysis.

A synthetic method of the compound containing nitrogen fused ring

The invention relates to a synthetic method of a nitrogen-containing fused ring compound. The method comprises the following step: in an organic solvent, by taking a copper compound as a catalyst, allowing a substrate with methoxyl to have an intramolecul

Under acidic conditions the indazole derivative synthesis of quinazolinone and method

The invention relates to a method for synthesizing quinazolino indazole derivatives under acidic condition, which comprises the following steps: under existence of a catalyst and an oxidizing agent, an intramolecular dehydrogenation coupling reaction of 2-aryl-3-aryl amino quinazolinone derivatives is produced in an acidic organic solvent so as to obtain the quinazolino indazole derivatives with diversified structures. The method is characterized in that under the synergistic effect of the catalyst, the oxidizing agent and the acidic organic solvent, a reaction for efficiently synthesizing the quinazolino indazole derivatives by a one-pot method is achieved, and the method has the advantages of high efficiency, environmental friendliness, high yield and purity and the like, and has good research value and application prospect.

Palladium-Catalyzed Cascade Reaction of 2-Amino-N′-arylbenzohydrazides with Triethyl Orthobenzoates To Construct Indazolo[3,2-b]quinazolinones

A palladium-catalyzed sequential cyclization/C-H activation cascade reaction of 2-amino-N′-arylbenzohydrazides with triethyl orthobenzoates has been developed, providing indazolo[3,2-b]quinazolinones in good to high yields. Two key intermediates of the re

Pd-catalyzed intramolecular aerobic oxidative C-H amination of 2-aryl-3-(arylamino)quinazolinones: Synthesis of fluorescent indazolo[3,2-b]quinazolinones

A palladium-catalyzed intramolecular aerobic oxidative C-H amination of 2-aryl-3-(arylamino)quinazolinones has been developed, providing a variety of substituted indazolo[3,2-b]quinazolinone derivatives in moderate to excellent yields. Preliminary mechani

Copper-catalyzed intramolecular C-N bond formation reaction of 3-amino-2-(2-bromophenyl)dihydroquinazolinones: Synthesis of indazolo[3,2-b]quinazolinones

A copper-catalyzed intramolecular C-N bond formation reaction of 3-amino-2-(2-bromophenyl)dihydroquinazolinones has been developed for the synthesis of indazolo[3,2-b]quinazolinones in moderate to good yields. The structure of the newly synthesized indazo

Copper(I)-catalyzed synthesis of 5-arylindazolo[3,2- b ]quinazolin-7(5 H)-one via ullmann-type reaction

The treatment of 2-amino-N′-arylbenzohydrazide and o-halogenated benzaldehyde in the presence of CuBr and Cs2CO3 gave 5-arylindazolo[3,2-b]quinazolin-7(5H)-one in high yields. This procedure contains an Ullmann-type reaction and prov