38507-49-2

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 1,6-dimethyl-3-(phenylmethyl)-
• CAS NO: 38507-49-2
• Molecular Formula: C13H14N2O2
• Molecular Weight: 230.266
• Mol File: 38507-49-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 1,6-dimethyl-3-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 1,6-dimethyl-3-(phenylmethyl)-(38507-49-2)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 1,6-dimethyl-3-(phenylmethyl)-(38507-49-2)

Safety Data

• Hazardous Substances Data: 38507-49-2(Hazardous Substances Data)

Upstream product

• 10128-99-1 3-benzyl-6-methyl-[1,3]oxazine-2,4-dione 
• 74-89-5 methylamine 
• 598-50-5 N-Methylurea 
• 6250-76-6 sarcosinamide 
• 25589-18-8 3-benzyl-6-methylpyrimidine-2,4(1H,3H)-dione 
• 77-78-1 dimethyl sulfate 
• 10128-98-0 3-benzyl-6-methyl-2-phenylimino-2,3-dihydro-[1,3]oxazin-4-one 
• 85102-59-6 1,3-dibenzyl-6-methylpyrimidine-2,4(1H,3H)-dione 
• 626-48-2 6-Methyluracil 
• 253142-19-7 3-benzyl-2-methoxy-6-methyl-4-pyrimidinone 
• 100-39-0 benzyl bromide 
• 1024-41-5 benzyl tosylate 
• 55996-28-6 6-methyl-2-methoxy-4(3H)-pyrimidinone 
• 74-88-4 methyl iodide 

Relevant articles and documents

HSAB driven chemoselectivity in alkylation of uracil derivatives. A high yielding preparation of 3-alkylated and unsymmetrically 1,3-dialkylated uracils

A qualitative hardness scale (N134) has been found for the conjugated bases of 2-methoxy-4(3H)-pyrimidinones 1-3 and applied to high yielding chemoselective N3 methylation, ethylation and benzylation reactions. Removal of the 2-methoxy group followed by a second alkylation affords unsymmetrically 1,3-disubstituted uracils.

Heterocyclic Transformations Part 4: A Facile Transformation of 3-Alkyl-6-methyl-1,3-oxazine-2,4(3H)-diones to 6-Substituted 5-acetyluracils and 6-Thioxo-1,3,5-triazine-2,4(1H,3H,5H)-diones

3-Benzyl-6-methyl-1,3-oxazine-2,4(3H)-dione 1 (R = CH2Ph) reacts under phase-transfer catalytic conditions with amides and thioamides to give 6-substituted 5-acetyluracils and with malonamide to give a bicyclic pyridopyrimidine system.Similar reactions of 1 with thioureas provide 6-thioxo-1,3,5-triazine-2,4(1H,3H,5H)-diones, but with ureas, the substituents influence the mode of the reaction and the nature of the products.The synthetic scope and utility of these reactions has been examined.